DGIdb - CHEMBL1161866 Drug Record

CHEMBL1161866 chembl:CHEMBL1161866

Alternate Names:

NADH

Drug Info:

Drug Categories	nucleic acids, nucleotides, and nucleosides
Drug Groups	approved
Drug Categories	heterocyclic compounds, fused-ring

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Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Kedishvili et al., 1991, The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenase., Arch. Biochem. Biophys.
Fonvielle et al., 2007, New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase., Bioorg. Med. Chem. Lett.
Auclair et al., 2003, Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae., Protein Expr. Purif.
Calò et al., 2003, Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling., Nephrol. Dial. Transplant.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Ngo et al., 2000, Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver., Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Linster et al., 2007, Vitamin C. Biosynthesis, recycling and degradation in mammals., FEBS J.
Ido, 2007, Pyridine nucleotide redox abnormalities in diabetes., Antioxid. Redox Signal.
McKinlay et al., 2007, Determining Actinobacillus succinogenes metabolic pathways and fluxes by NMR and GC-MS analyses of 13C-labeled metabolic product isotopomers., Metab. Eng.
Wroczyński et al., Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays., Acta Pol Pharm
Russo et al., 2002, 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal., BMC Pharmacol.
Lamb et al., 1999, The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity., Biochemistry
Fukuda et al., 1986, Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta., Endocrinol. Jpn.
Pineda et al., 1989, Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase., J. Steroid Biochem.
Wintergalen et al., 1995, Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity., Eur. J. Biochem.
Wei et al., 2006, Identification of cold acclimation-responsive Rhododendron genes for lipid metabolism, membrane transport and lignin biosynthesis: importance of moderately abundant ESTs in genomic studies., Plant Cell Environ.
Rzem et al., 2007, L-2-hydroxyglutaric aciduria, a defect of metabolite repair., J. Inherit. Metab. Dis.
Luo et al., 2006, An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates., J. Biochem. Biophys. Methods
Albracht et al., 2000, Learning from hydrogenases: location of a proton pump and of a second FMN in bovine NADH--ubiquinone oxidoreductase (Complex I)., FEBS Lett.
Jose Quiles M et al., 1998, Association of ferredoxin-NADP oxidoreductase with the chloroplastic pyridine nucleotide dehydrogenase complex in barley leaves, Plant Physiol.
Loeffen et al., 1998, The first nuclear-encoded complex I mutation in a patient with Leigh syndrome., Am. J. Hum. Genet.
Pandey et al., 2007, Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase., Mol. Endocrinol.
Stein et al., 1967, Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues., Biochemistry
SANWAL et al., 1964, NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN., J. Biol. Chem.
Rose, 1966, The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction., J. Biol. Chem.
Loeffen et al., 1999, The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients., J. Inherit. Metab. Dis.
Mercer et al., 1992, Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney., Endocrinology
Hermans et al., 1995, Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats., Steroids
Testore et al., 1995, Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver., Int. J. Biochem. Cell Biol.
Prieto et al., Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli., Biochimie
Trost et al., 2006, Thioredoxin-dependent regulation of photosynthetic glyceraldehyde-3-phosphate dehydrogenase: autonomous vs. CP12-dependent mechanisms., Photosyn. Res.
Markova et al., [Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes]., Biomed Khim
Swearengin et al., 2006, Sevoflurane modulates the activity of glyceraldehyde 3-phosphate dehydrogenase., J Enzyme Inhib Med Chem
Inano et al., 1975, Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17 beta-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction., Eur. J. Biochem.
Iskander et al., 2006, NQO1 and NQO2 regulation of humoral immunity and autoimmunity., J. Biol. Chem.
Jamieson et al., 2006, Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor., Br. J. Cancer
Forlani et al., 2007, Plant P5C reductase as a new target for aminomethylenebisphosphonates., J. Agric. Food Chem.
Wang et al., 2007, Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinity., J. Plant Physiol.
Razeto et al., 2002, Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus., J. Mol. Biol.
Mdluli et al., 2005, A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism., Biochim. Biophys. Acta
Clausen, 1969, Lactate dehydrogenase isoenzymes of sperm cells and tests., Biochem. J.
van der Heiden et al., 1982, Spectral studies of the interaction of the substrate 'quinonoid' 6-methyl dihydropterine and the coenzyme NADH used as marker in the dihydropteridine reductase assay., J. Inherit. Metab. Dis.
Nakanishi et al., 1986, Determination of NADPH-specific dihydropteridine reductase in extract from human, monkey, and bovine livers by single radial immunodiffusion: selective assay differentiating NADPH- and NADH-specific enzymes., J. Biochem.
Lee et al., 2000, NADH-ferric reductase activity associated with dihydropteridine reductase., Biochem. Biophys. Res. Commun.
Xu et al., 2006, Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae., Biochemistry
Xu et al., 2007, A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae., Biochemistry
Xu et al., 2007, Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae., Biochemistry
de La Fuente et al., 1997, Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes., Biochem. J.
Belevich et al., 2007, Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli., Biochemistry
Chen et al., 2007, Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase., Biochemistry
Alary et al., 1992, Mechanism of cadmium-decreased glucuronidation in the rat., Biochem. Pharmacol.
Castellani et al., Regulatory mechanisms of UDP-glucuronic acid biosynthesis in cultured human skin fibroblasts., Ital. J. Biochem.
Tabata et al., 1995, A chemiluminescence-flow injection analysis of serum 3-hydroxybutyrate using a bioreactor consisting of 3-hydroxybutyrate dehydrogenase and NADH oxidase., Anal. Biochem.
Rudy et al., 1989, Coenzyme binding by 3-hydroxybutyrate dehydrogenase, a lipid-requiring enzyme: lecithin acts as an allosteric modulator to enhance the affinity for coenzyme., Biochemistry
Smith et al., 1979, Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate., Eur. J. Biochem.
Ishii-Ohba et al., 1987, Testicular and adrenal 3 beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase., J. Steroid Biochem.
Thomas et al., 1990, Affinity alkylation of human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase by 2 alpha-bromoacetoxyprogesterone: evidence for separate dehydrogenase and isomerase sites on one protein., J. Steroid Biochem.
Widenius et al., 1987, Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells., J. Steroid Biochem.
Gao et al., 2007, Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts., Endocrinology
Klimacek et al., 2007, Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase., Biochem. J.
Roma et al., 2006, Expression and characterization of a functional canine variant of cytochrome b5 reductase., Arch. Biochem. Biophys.
Kim et al., 2007, Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
Nussenzveig et al., 2006, A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia., Haematologica
Kurian et al., 2006, Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5., Chem. Res. Toxicol.
Ikegami et al., 2007, Structure and properties of the recombinant NADH-cytochrome b5 reductase of Physarum polycephalum., Biosci. Biotechnol. Biochem.
Mailloux et al., 2007, The tricarboxylic acid cycle, an ancient metabolic network with a novel twist., PLoS ONE
Yennaco et al., 2007, Characterization of malate dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum., Extremophiles
Bäumchen et al., 2007, D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium., Biotechnol J
Gallarta et al., 2007, Fluorescent sensing layer for the determination of L-malic acid in wine., Anal Bioanal Chem
Graham et al., 2006, Characterization of retinaldehyde dehydrogenase 3., Biochem. J.
Haapalainen et al., 2003, Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution., Structure
Quiles, 2006, Stimulation of chlororespiration by heat and high light intensity in oat plants., Plant Cell Environ.
Gyan et al., 2006, Regulatory loop between redox sensing of the NADH/NAD(+) ratio by Rex (YdiH) and oxidation of NADH by NADH dehydrogenase Ndh in Bacillus subtilis., J. Bacteriol.
Brooijmans et al., 2007, Generation of a membrane potential by Lactococcus lactis through aerobic electron transport., J. Bacteriol.
Zhu et al., 2007, Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption., Am. J. Physiol. Heart Circ. Physiol.
Bao et al., 2007, Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos., Anim. Genet.
Atalla et al., 2000, Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol., Xenobiotica
Albracht, 1993, Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase., Biochim. Biophys. Acta
Hyslop et al., 1996, Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13., Genomics
Schuler et al., 1999, NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone., Proc. Natl. Acad. Sci. U.S.A.
Murahama et al., 2001, Purification and characterization of Delta(1)-pyrroline-5-carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves., Plant Cell Physiol.
Taylor et al., 1975, Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio., J. Biol. Chem.
Grad et al., 2004, Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis., Hum. Mol. Genet.
Schuelke et al., 1998, Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation?, Biochem. Biophys. Res. Commun.
Ali et al., 1993, Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13., Genomics
Goldsmith et al., 1976, Serine biosynthesis in human hair follicles by the phosphorylated pathway: follicular 3-phosphoglycerate dehydrogenase., J. Invest. Dermatol.
Grant et al., 2002, Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding., J. Biol. Chem.
Grant, 1989, A new family of 2-hydroxyacid dehydrogenases., Biochem. Biophys. Res. Commun.
Bowne et al., 2006, Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis., Invest. Ophthalmol. Vis. Sci.
Bieganowski et al., 2006, Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions., J. Biol. Chem.
Manríquez et al., 2006, Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics., Plant Mol. Biol.
Cunningham et al., 2005, Changes in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblasts., J. Lipid Res.
Diederich et al., 1997, Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction., J. Clin. Endocrinol. Metab.
Bognar et al., 1983, Mechanism of a long-chain fatty aldehyde dehydrogenase induced during the development of bioluminescence in Beneckea harveyi., Can. J. Biochem. Cell Biol.
Petruzzella et al., 2001, A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome., Hum. Mol. Genet.
Papa et al., 2002, The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade., J. Bioenerg. Biomembr.
Raha et al., 2002, Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase., Free Radic. Biol. Med.
Kabus et al., 2007, Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation., Appl. Microbiol. Biotechnol.
Deng et al., 2007, Characterization of two components of the 2-naphthoate monooxygenase system from Burkholderia sp. strain JT1500., FEMS Microbiol. Lett.
Rimsay et al., 1988, The 20 alpha-hydroxysteroid dehydrogenase of Streptomyces hydrogenans., Eur. J. Biochem.
Zafar et al., 2006, A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition., Mol. Pharmacol.
Jadhav et al., 2007, Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463., Chemosphere
Gutiérrez-Correa, 2006, Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants., Curr Drug Targets
Islam et al., 2007, A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex., J. Biol. Chem.
Yan et al., 2007, Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE., Electrophoresis
Nikonova et al., 2005, Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness., Sleep
Zhang et al., 2003, [The changes of gene expression in multiple myeloma treated with thalidomide]., Zhonghua Nei Ke Za Zhi
Zhang et al., 2007, Coimmobilization of dehydrogenases and their cofactors in electrochemical biosensors., Anal. Chem.
Takenaka et al., 2007, In vitro RNA editing in plant mitochondria does not require added energy., FEBS Lett.
Lu et al., 2007, Co-expression of P450 BM3 and glucose dehydrogenase by recombinant Escherichia coli and its application in an NADPH-dependent indigo production system., J. Ind. Microbiol. Biotechnol.
Siu et al., Electrochemical regeneration of NADH using conductive vanadia-silica xerogels., Biotechnol. Prog.
Franklin et al., 2007, Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions., Biochem. J.
O'Brien et al., Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons., Neurochem. Res.
Drăghia, 2006, Histochemical and histopathological study of the gastric mucosa in the portal hypertensive gastropathy., Rom J Morphol Embryol
Semenza, 2007, Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1., Biochem. J.
Norman et al., 2007, HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons., J. Immunol.
Inagaki et al., 2006, Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase., J. Mol. Biol.
Barker et al., 2007, The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry., Biochemistry
Fisher et al., 2007, The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle., Trends Parasitol.
Balaban, 2006, Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach., Ann. N. Y. Acad. Sci.
Liu et al., 2008, Cloning and sequence analysis of the gene encoding 19-kD subunit of Complex I from Dunaliella salina., Mol. Biol. Rep.
Matsuzaki et al., 2007, Inhibition of complex I by Ca2+ reduces electron transport activity and the rate of superoxide anion production in cardiac submitochondrial particles., Biochemistry
Burczynski et al., 2001, The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene., J. Biol. Chem.
Vickers et al., 2006, Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence., J. Biol. Chem.
Argyrou et al., 2006, Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis., Biochemistry
Fan et al., 1975, Studies of the human testis. VII. Conversion of pregnenolone to progesterone., J. Clin. Endocrinol. Metab.
Thomas et al., 1991, Analysis of coenzyme binding by human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase using 5'-[p-(fluorosulfonyl)benzoyl]adenosine, an affinity labeling cofactor analog., J. Steroid Biochem. Mol. Biol.
Okochi et al., 2007, Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reductive production of steroids., J. Biotechnol.
Schirwitz et al., 2007, High-resolution structures of formate dehydrogenase from Candida boidinii., Protein Sci.
Baron et al., 2006, Logic gates and elementary computing by enzymes., J Phys Chem A
Shen et al., Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells., Photochem. Photobiol.
Dzelzkalns et al., 1994, Deletion of the structural gene for the NADH-dehydrogenase subunit 4 of Synechocystis 6803 alters respiratory properties., Plant Physiol.
Carper et al., 1999, Oxidative stress induces differential gene expression in a human lens epithelial cell line., Invest. Ophthalmol. Vis. Sci.
Plapp et al., 2003, Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism., Chem. Biol. Interact.
Shi et al., 2006, Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis., Infect. Immun.
Johnson et al., 1997, Phylogenetic reconstruction of the Felidae using 16S rRNA and NADH-5 mitochondrial genes., J. Mol. Evol.
Li et al., 2003, 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk., Gen. Comp. Endocrinol.
Hedl et al., 2004, Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii., Protein Sci.
Huber et al., 2005, Improved posthypoxic recovery in vitro on treatment with drugs used for secondary stroke prevention., Neuropharmacology
Widenius, 1987, Ethanol-induced inhibition of testosterone biosynthesis in vitro: lack of acetaldehyde effect., Alcohol Alcohol.
Plapp et al., 2001, Mouse alcohol dehydrogenase 4: kinetic mechanism, substrate specificity and simulation of effects of ethanol on retinoid metabolism., Chem. Biol. Interact.
Thielen et al., 1991, Biochemical basis of mitochondrial acetaldehyde dismutation in Saccharomyces cerevisiae., J. Bacteriol.
Pineda et al., 1990, Stereospecificity of hydrogen transfer between progesterone and cofactor by human placental estradiol-17 beta dehydrogenase., J. Steroid Biochem. Mol. Biol.
Nicolas et al., 1983, Bioluminescent assay of femtomole levels of estrone and estradiol., Anal. Biochem.
Au et al., 1999, The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria., Proc. Natl. Acad. Sci. U.S.A.
PLAUT et al., 1954, Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues., J. Biol. Chem.
Wang et al., 2007, A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity., Pharmacogenet. Genomics
Quintanilla et al., 2006, The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake., Addict Biol
Quintanilla et al., 2007, Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective., Am. J. Physiol. Endocrinol. Metab.
Ismail et al., 2005, Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase., Acta Crystallogr. D Biol. Crystallogr.
Graciet et al., 2003, Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12., Eur. J. Biochem.
Maeda et al., 2004, Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae., Microbes Infect.
Dalfó et al., 2007, Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family., FEBS J.
Kim et al., 2001, Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues., J. Korean Med. Sci.
Suzuki et al., 1993, Identification and immunohistochemistry of retinol dehydrogenase from bovine retinal pigment epithelium., Biochim. Biophys. Acta
Trauger et al., 2002, Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2)., Biochemistry
Rizner et al., 2003, Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells., Endocrinology
Spielmann et al., 1976, Rapid purification of lactate dehydrogenase X from mouse testes by two steps of affinity chromatography on oxamate-sepharose., Experientia
Gu et al., 1989, Developmental changes in lactate dehydrogenase-X activity in young jaundiced male rats., Arch. Androl.
Morris et al., 1986, Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers., J. Reprod. Fertil.
Tanaka et al., 2006, DNA cleavage by UVA irradiation of NADH with dioxygen via radical chain processes., J Phys Chem A
Goldstone et al., 2006, Inactivation of copper, zinc superoxide dismutase by H2O2 : mechanism of protection., Free Radic. Biol. Med.
Paunesku et al., 2000, Identification of genes regulated by UV/salicylic acid., Int. J. Radiat. Biol.
Drew et al., 2007, Heterologous expression of cDNAs encoding monodehydroascorbate reductases from the moss, Physcomitrella patens and characterization of the expressed enzymes., Planta
Aon et al., 2007, Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status., J. Biol. Chem.
Cheng et al., 2007, The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila., Biochemistry
Wan et al., 2007, Damage of oxidative stress on mitochondria during microspores development in Honglian CMS line of rice., Plant Cell Rep.
Knapp et al., 2007, Evidence for an additional disulfide reduction pathway in Escherichia coli., J. Biosci. Bioeng.
Gazaryan et al., 2007, Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition., J. Biol. Chem.
Triepels et al., 1998, The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients., Hum. Genet.

CHEMBL1161866 LDHC

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
182529 2751392 17139284 17016423 3735252

Sources:
DrugBank
CHEMBL1161866 ADH7

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17608724 11410692 8490052 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 H6PD

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17298031 17531229 16898590 17171348 17269701

Sources:
DrugBank
CHEMBL1161866 PHGDH

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
945314 12183470 2692566 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 BDH1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8533882 2550053 17139284 17016423 38961

Sources:
DrugBank
CHEMBL1161866 IDH3B

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4292141 14189899 17139284 17016423 4380379

Sources:
DrugBank
CHEMBL1161866 ALDH9A1

Interaction Score: 1.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7584606 3129020 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NSDHL

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15805545 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 HSD17B4

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12517343 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ALDH1A3

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 16241904 17016423

Sources:
DrugBank
CHEMBL1161866 ALDH6A1

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1898092 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 IDH3G

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4292141 14189899 17139284 17016423 4380379

Sources:
DrugBank
CHEMBL1161866 PDHA2

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 LDHAL6B

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 EHHADH

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 HSD3B2

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
239964 1911436 17139284 3476810 17016423

Sources:
DrugBank
CHEMBL1161866 MSMO1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 HSD17B7

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 DHCR7

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 HADHA

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 HIBADH

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ALDH1B1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 TSTA3

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 QDPR

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6820434 3086306 10814540 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 PDHA1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 HSD17B2

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3463506 17139284 2615366 17016423 8529651

Sources:
DrugBank
CHEMBL1161866 LDHAL6A

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ALDH3B1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 UGDH

Interaction Score: 0.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1472079 17139284 3804697 17016423

Sources:
DrugBank
CHEMBL1161866 ADH4

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 3593480 11306066 1938903

Sources:
DrugBank
CHEMBL1161866 RDH5

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17608724

Sources:
DrugBank
CHEMBL1161866 ALDH4A1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16934832

Sources:
DrugBank
CHEMBL1161866 BLVRA

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17402939

Sources:
DrugBank
CHEMBL1161866 DLD

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17017892 17314104 17315258

Sources:
DrugBank
CHEMBL1161866 ALDH3A2

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6603890 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 PDHB

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 1116996 17016423

Sources:
DrugBank
CHEMBL1161866 PYCR2

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11479381 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 HSD17B3

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 237755

Sources:
DrugBank
CHEMBL1161866 AKR1C2

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12416991 12810547 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ADH5

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17092593 17525463 16821840 17619232

Sources:
DrugBank
CHEMBL1161866 IDH3A

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4292141 13152105 17139284 17016423 4380379

Sources:
DrugBank
CHEMBL1161866 HSD17B8

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 CDO1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 MT-ND4

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15560738 17139284 7846157 17016423 9950599

Sources:
DrugBank
CHEMBL1161866 MTHFD2

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 MT-ND2

Interaction Score: 0.59

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
11752352 17139284 15700717 17016423 12882707

Sources:
DrugBank
CHEMBL1161866 NDUFS4

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11181577 11860175 17139284 17016423 11864782

Sources:
DrugBank
CHEMBL1161866 NDUFV1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14662656 9571201 8288251 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFS7

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8369340 8938450 10097178 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 MDH2

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17487443 16898590 17619232 17603759 17203264

Sources:
DrugBank
CHEMBL1161866 SORD

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17343568 17508915

Sources:
DrugBank
CHEMBL1161866 LDHB

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12054772 16198644 4303363 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 PYCR1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17474756 16777263

Sources:
DrugBank
CHEMBL1161866 NDUFS8

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11086155 9576793 17139284 17016423 9837812

Sources:
DrugBank
CHEMBL1161866 ACADS

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ALDH3B2

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 GLUD2

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 DLAT

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 16368957

Sources:
DrugBank
CHEMBL1161866 AKR1C4

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11037109 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ALDH7A1

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9355735 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 AASS

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17002315 17223709 17542618

Sources:
DrugBank
CHEMBL1161866 CYP4A11

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11246504 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 11864782 10200266

Sources:
DrugBank
CHEMBL1161866 MT-ND5

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9071018 17139284 17016423 17614984

Sources:
DrugBank
CHEMBL1161866 MT-ND3

Interaction Score: 0.49

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
11752352 17139284 17016423

Sources:
TTD DrugBank
CHEMBL1161866 NDUFA9

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17323923 17499024 17132781 17530440 17260964

Sources:
DrugBank
CHEMBL1161866 NDUFC2

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16898010 17015645 17496098 17513495 17614984

Sources:
DrugBank
CHEMBL1161866 GAPDHS

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16239728 17139284 17016423 12492483 15488735

Sources:
DrugBank
CHEMBL1161866 ME2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 AMT

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 MTHFD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA8

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9860297 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFV2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10716640 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFB7

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 11864782

Sources:
DrugBank
CHEMBL1161866 HADH

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17202348

Sources:
DrugBank
CHEMBL1161866 OGDH

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17668068

Sources:
DrugBank
CHEMBL1161866 NDUFS5

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10070614 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ALDH1A2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10320326 17139284 11872149 17016423

Sources:
DrugBank
CHEMBL1161866 ME1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17197218

Sources:
DrugBank
CHEMBL1161866 GPD1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17088060

Sources:
DrugBank
CHEMBL1161866 NDUFB10

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 HMOX2

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16986858 17157188

Sources:
DrugBank
CHEMBL1161866 NDUFB5

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFS1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFC1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFB8

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA7

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA10

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFB6

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 HSD17B1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3463506 3164265 17139284 2615366 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFS6

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA12

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFB2

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 MT-ND6

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA4L2

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFS3

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFB9

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 MT-ND4L

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA3

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFS2

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFB4

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFB3

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA4

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA5

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17209562 17444656

Sources:
DrugBank
CHEMBL1161866 NDUFA6

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA11

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA2

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFB1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFA13

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFAB1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 MDH1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16983536

Sources:
DrugBank
CHEMBL1161866 HSD3B1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2961942 2362440 17139284 3476810 17016423

Sources:
DrugBank
CHEMBL1161866 ME3

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17080607 17603759 16740313

Sources:
DrugBank
CHEMBL1161866 HMOX1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12699699 17139284 17016423 12897089

Sources:
DrugBank
CHEMBL1161866 GLUD1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 NDUFV3

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ALDH3A1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16583981 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 LDHA

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17006762 17308685 17555402

Sources:
DrugBank
CHEMBL1161866 AKR1C1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3463506 11060293 17139284 2615366 17016423

Sources:
DrugBank
CHEMBL1161866 CYB5R3

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16814740 17401193 17082011 17040106 17341833

Sources:
DrugBank
CHEMBL1161866 ADH1A

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16760478 16897483

Sources:
DrugBank
CHEMBL1161866 NNT

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17216441

Sources:
DrugBank
CHEMBL1161866 HSD11B2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1727721 17139284 8585102 17016423

Sources:
DrugBank
CHEMBL1161866 MT-ND1

Interaction Score: 0.16

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
11752352 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ALDH5A1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL1161866 AKR1C3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 2146972 2615366 17016423 6584048

Sources:
DrugBank
CHEMBL1161866 ALDH2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16961761 17488809

Sources:
DrugBank
CHEMBL1161866 BLVRB

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17559398

Sources:
DrugBank
CHEMBL1161866 IMPDH1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16384941 17139284 17016423

Sources:
DrugBank
CHEMBL1161866 ADH1C

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 12604203

Sources:
DrugBank
CHEMBL1161866 GSR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17540766 17550271 17053903 17502280 17565998

Sources:
DrugBank
CHEMBL1161866 TYR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16790533 17292452

Sources:
DrugBank
CHEMBL1161866 GAPDH

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17031544 16898590 17194030 17508915

Sources:
DrugBank
CHEMBL1161866 HSD11B1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9141556 17139284 8585102 17016423

Sources:
DrugBank
CHEMBL1161866 HMGCR

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14511985 17139284 17016423 15152097 15755483

Sources:
DrugBank
CHEMBL1161866 ADH1B

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16897483

Sources:
DrugBank
CHEMBL1161866 IMPDH2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17496727

Sources:
DrugBank
CHEMBL1161866 CYP17A1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17595315

Sources:
DrugBank
CHEMBL1161866 NQO2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16905546 17031400

Sources:
DrugBank
CHEMBL1161866 AKR1B1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17222174 17508915

Sources:
DrugBank
CHEMBL1161866 DHFR

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17032644 17115689

Sources:
DrugBank
CHEMBL1161866 ALDH1A1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16583981 17139284 11872149 17016423

Sources:
DrugBank
CHEMBL1161866 HPGD

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17463062

Sources:
DrugBank
CHEMBL1161866 HSD17B10

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank

DrugBank: DB00157

Version: 5.1.7

Alternate Names:

NADH DrugBank Drug Name

58-68-4 CAS Number

BumP DHA Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups nutraceutical

Publications:

Alary et al., 1992, Mechanism of cadmium-decreased glucuronidation in the rat., Biochem. Pharmacol.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Castellani et al., Regulatory mechanisms of UDP-glucuronic acid biosynthesis in cultured human skin fibroblasts., Ital. J. Biochem.

TTD: NADH
- Version: 2020.06.01
Alternate Names:

D0B8SV TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1161866
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Drug Type	small molecule
Drug Groups	approved
Drug Groups	nutraceutical

CHEMBL1161866 Drug Record

CHEMBL1161866 chembl:CHEMBL1161866

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 182529 2751392 17139284 17016423 3735252

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17608724 11410692 8490052 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17298031 17531229 16898590 17171348 17269701

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 945314 12183470 2692566 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8533882 2550053 17139284 17016423 38961

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4292141 14189899 17139284 17016423 4380379

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7584606 3129020 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15805545 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12517343 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 16241904 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1898092 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4292141 14189899 17139284 17016423 4380379

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 239964 1911436 17139284 3476810 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Interaction Types & Directionality:

n/a

PMIDs:
182529 2751392 17139284 17016423 3735252

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17608724 11410692 8490052 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17298031 17531229 16898590 17171348 17269701

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
945314 12183470 2692566 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
8533882 2550053 17139284 17016423 38961

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
4292141 14189899 17139284 17016423 4380379

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
7584606 3129020 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15805545 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12517343 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 16241904 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
1898092 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
4292141 14189899 17139284 17016423 4380379

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
239964 1911436 17139284 3476810 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
6820434 3086306 10814540 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
3463506 17139284 2615366 17016423 8529651

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423