• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

CHEMBL282093 Drug Record

  • Summary
  • Interactions
  • Claims
  • CHEMBL282093 chembl:CHEMBL282093

    Alternate Names:

    SC-58236

    Drug Info:

    Drug Categories sulfur compounds
    Drug Categories sulfones
    Drug Categories sensory system agents
    Drug Categories peripheral nervous system agents
    Drug Categories nephrotoxic agents
    Drug Categories enzyme inhibitors
    Drug Categories cyclooxygenase inhibitors
    Drug Categories central nervous system agents
    Drug Categories antirheumatic agents
    Drug Categories anti-inflammatory agents, non-steroidal
    Drug Categories anti-inflammatory agents
    Drug Categories analgesics, non-narcotic
    Drug Categories analgesics
    Drug Categories amides
    Drug Categories agents that produce hypertension
    Drug Categories agents causing hyperkalemia
    Drug Groups investigational
    Drug Groups experimental
    Drug Type small molecule
    (0 More Sources)

    Publications:

    Kim SJ et al., 2005, Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells., J Pharmacol Exp Ther
    Wong BC et al., 2003, Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer., Oncogene
  • CHEMBL282093   NFKB2

    Interaction Score: 3.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15784648 12606945


    Sources:
    DrugBank

  • DrugBank: DB14059

    • Version: 5.1.7

    Alternate Names:
    SC-236 DrugBank Drug Name
    170569-86-5 CAS Number
    CHEMBL282093 ChEMBL ID

    Drug Info:
    Drug Type small molecule
    Drug Groups experimental
    Drug Groups investigational

    Publications:
    Kim SJ et al., 2005, Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells., J Pharmacol Exp Ther
    Wong BC et al., 2003, Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer., Oncogene

  • ChemblDrugs: chembl:CHEMBL282093

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13