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CHEMBL35482 Drug Record

  • Summary
  • Interactions
  • Claims
  • CHEMBL35482 chembl:CHEMBL35482

    Alternate Names:

    PD-98059

    Drug Info:

    (0 More Sources)

    Publications:

    Nishikawa et al., 2005, Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro., Am. J. Pathol.
    Andreis et al., 2000, Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: receptor subtype involved and signaling mechanism., Endocrinology
    Gilad et al., 2005, Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells., J. Endocrinol.
    Carter et al., 2001, Cytokine-regulated expression of survivin in myeloid leukemia., Blood
    Takeuchi et al., 2001, Epidermal growth factor induces expression of decay-accelerating factor in human colonic cancer cells via the mitogen-activated protein kinase pathway., J. Lab. Clin. Med.
    Bannach et al., 2004, Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta)., J. Thromb. Haemost.
    Yoo et al., 2004, Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha., J. Biol. Chem.
    Petersen et al., 2002, Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization., FEBS Lett.
    Kuo et al., 2005, Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells., J. Pharmacol. Exp. Ther.
    Lepique et al., 2000, Signal transduction in G0/G1-arrested mouse Y1 adrenocortical cells stimulated by ACTH and FGF2., Endocr. Res.
    Hoshino et al., 2001, Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1)., J. Biol. Chem.
    Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.
    Alblas et al., 1998, The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells., Oncogene
    Paine et al., 2000, Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway., J. Biol. Chem.
    Kim et al., 2002, Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells., Mol. Pharmacol.
    Tai et al., 2001, Adenosine triphosphate activates mitogen-activated protein kinase in human granulosa-luteal cells., Endocrinology
    Walther et al., 2006, Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells., Reprod. Biol. Endocrinol.
    Yeh et al., 1999, From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells., Proc. Natl. Acad. Sci. U.S.A.
    Li et al., 2001, Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development., Oncogene
    Matsui et al., Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor., Oncol. Rep.
  • CHEMBL35482   DSG1

    Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11781826


    Sources:
    NCI

  • CHEMBL35482   CD55

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11528371


    Sources:
    NCI

  • CHEMBL35482   KRT19

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15793288


    Sources:
    NCI

  • CHEMBL35482   CGB5

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11250936


    Sources:
    NCI

  • CHEMBL35482   MUC2

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12391274


    Sources:
    NCI

  • CHEMBL35482   NEUROD1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12297313


    Sources:
    NCI

  • CHEMBL35482   ADM

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10830296


    Sources:
    NCI

  • CHEMBL35482   NR5A1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17176485


    Sources:
    NCI

  • CHEMBL35482   NR4A1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15385570


    Sources:
    NCI

  • CHEMBL35482   CDKN1B

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11031257


    Sources:
    NCI

  • CHEMBL35482   MDM2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15385570


    Sources:
    NCI

  • CHEMBL35482   MAPK10

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9467952 10753939


    Sources:
    NCI

  • CHEMBL35482   BGLAP

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15956019


    Sources:
    NCI

  • CHEMBL35482   PLG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15613028


    Sources:
    NCI

  • CHEMBL35482   HRAS

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12883735


    Sources:
    NCI

  • CHEMBL35482   BIRC5

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11313272


    Sources:
    NCI

  • CHEMBL35482   MYC

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11196459


    Sources:
    NCI

  • CHEMBL35482   SLC2A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11978788


    Sources:
    NCI

  • CHEMBL35482   PKM

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   MAPK3

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   ERBB2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10318905


    Sources:
    NCI

  • CHEMBL35482   THPO

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   SMN2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   SMN1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   NPC1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   RAB9A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15930183


    Sources:
    NCI

  • CHEMBL35482   HPGD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   ATAD5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   TP53

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   CYP2C9

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   MAPT

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   CYP2C19

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: PD-98059

    • Version: 14-September-2017

    Alternate Names:
    C1625 NCI drug code

    Drug Info:

    Publications:
    Nishikawa et al., 2005, Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro., Am. J. Pathol.
    Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.
    Tai et al., 2001, Adenosine triphosphate activates mitogen-activated protein kinase in human granulosa-luteal cells., Endocrinology

  • DTC: PD-98059

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL35482 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL35482

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21