DGIdb - CHEMBL35482 Drug Record

CHEMBL35482 chembl:CHEMBL35482

Alternate Names:

PD-98059

Drug Info:

(0 More Sources)

Publications:

Nishikawa et al., 2005, Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro., Am. J. Pathol.
Andreis et al., 2000, Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: receptor subtype involved and signaling mechanism., Endocrinology
Gilad et al., 2005, Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells., J. Endocrinol.
Carter et al., 2001, Cytokine-regulated expression of survivin in myeloid leukemia., Blood
Takeuchi et al., 2001, Epidermal growth factor induces expression of decay-accelerating factor in human colonic cancer cells via the mitogen-activated protein kinase pathway., J. Lab. Clin. Med.
Bannach et al., 2004, Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta)., J. Thromb. Haemost.
Yoo et al., 2004, Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha., J. Biol. Chem.
Petersen et al., 2002, Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization., FEBS Lett.
Kuo et al., 2005, Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells., J. Pharmacol. Exp. Ther.
Lepique et al., 2000, Signal transduction in G0/G1-arrested mouse Y1 adrenocortical cells stimulated by ACTH and FGF2., Endocr. Res.
Hoshino et al., 2001, Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1)., J. Biol. Chem.
Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.
Alblas et al., 1998, The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells., Oncogene
Paine et al., 2000, Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway., J. Biol. Chem.
Kim et al., 2002, Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells., Mol. Pharmacol.
Tai et al., 2001, Adenosine triphosphate activates mitogen-activated protein kinase in human granulosa-luteal cells., Endocrinology
Walther et al., 2006, Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells., Reprod. Biol. Endocrinol.
Yeh et al., 1999, From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells., Proc. Natl. Acad. Sci. U.S.A.
Li et al., 2001, Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development., Oncogene
Matsui et al., Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor., Oncol. Rep.

CHEMBL35482 DSG1

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11781826

Sources:
NCI
CHEMBL35482 CD55

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11528371

Sources:
NCI
CHEMBL35482 KRT19

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15793288

Sources:
NCI
CHEMBL35482 CGB5

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11250936

Sources:
NCI
CHEMBL35482 MUC2

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12391274

Sources:
NCI
CHEMBL35482 NEUROD1

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12297313

Sources:
NCI
CHEMBL35482 ADM

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10830296

Sources:
NCI
CHEMBL35482 NR5A1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17176485

Sources:
NCI
CHEMBL35482 NR4A1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15385570

Sources:
NCI
CHEMBL35482 CDKN1B

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11031257

Sources:
NCI
CHEMBL35482 MDM2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15385570

Sources:
NCI
CHEMBL35482 MAPK10

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9467952 10753939

Sources:
NCI
CHEMBL35482 BGLAP

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15956019

Sources:
NCI
CHEMBL35482 PLG

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15613028

Sources:
NCI
CHEMBL35482 HRAS

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12883735

Sources:
NCI
CHEMBL35482 BIRC5

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11313272

Sources:
NCI
CHEMBL35482 MYC

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11196459

Sources:
NCI
CHEMBL35482 SLC2A4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11978788

Sources:
NCI
CHEMBL35482 PKM

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 MAPK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 ERBB2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10318905

Sources:
NCI
CHEMBL35482 THPO

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 SMN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 SMN1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 NPC1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 RAB9A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15930183

Sources:
NCI
CHEMBL35482 HPGD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 TP53

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 CYP2C9

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 MAPT

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 CYP2C19

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: PD-98059

Version: 14-September-2017

Alternate Names:

C1625 NCI drug code

Drug Info:

Publications:

Nishikawa et al., 2005, Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro., Am. J. Pathol.

Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.

Tai et al., 2001, Adenosine triphosphate activates mitogen-activated protein kinase in human granulosa-luteal cells., Endocrinology

DTC: PD-98059
- Version: 02-September-2020
Alternate Names:

CHEMBL35482 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL35482
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

CHEMBL35482 Drug Record

CHEMBL35482 chembl:CHEMBL35482

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11781826

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11528371

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15793288

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11250936

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12391274

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12297313

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10830296

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17176485

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15385570

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11031257

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15385570

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9467952 10753939

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15956019

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15613028

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12883735

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11313272

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11196459

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11978788

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
11781826

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11528371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15793288

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11250936

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12391274

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12297313

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10830296

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17176485

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15385570

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11031257

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15385570

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9467952 10753939

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15956019

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15613028

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12883735

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11313272

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11196459

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11978788

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10318905

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found