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CHENODIOL Drug Record

  • Summary
  • Interactions
  • Claims
  • CHENODIOL chembl:CHEMBL240597 Approved

    Alternate Names:

    CHENODIOL
    CHENIC ACID
    CHENOFALK
    CHENODEOXYCHOLIC ACID
    CHENOCEDON
    XENBILOX
    CHENIX
    COMBIDOL
    LITHOFALK
    CHENDOL 250
    NSC-657949
    CHENDOL 125
    CHENODEOXYCHOLATE
    7ALPHA-HYDROXYLITHOCHOLIC ACID
    (3A,5B,7A)-3,7-DIHYDROXY-CHOLAN-24-OATE
    (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-DIHYDROXY-10,13-DIMETHYL-2,3,4,5,6,7,8,9,11,12,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOIC ACID
    (+)-CHENODEOXYCHOLIC ACID
    CHENODESOXYCHOLSAEURE
    (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-DIMETHYL-3,7-BIS(OXIDANYL)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOIC ACID
    3A,7A-DIHYDROXY-5B-CHOLAN-24-OIC ACID
    3A,7A-DIHYDROXY-5B-CHOLANIC ACID
    3A,7A-DIHYDROXY-5B,14A,17B-CHOLANIC ACID
    ANTHROPODEOXYCHOLIC ACID
    CHENODESOXYCHOLIC ACID
    (4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-DIHYDROXY-2,15-DIMETHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECAN-14-YL]PENTANOIC ACID
    (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-DIHYDROXY-10,13-DIMETHYL-2,3,4,5,6,7,8,9,11,12,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]VALERIC ACID
    GALLODESOXYCHOLIC ACID
    ANTHROPODESOXYCHOLIC ACID
    CHENODIOL®
    (3A,5B,7A)-3,7-DIHYDROXY-CHOLAN-24-OIC ACID
    CHENIX®
    3ALPHA,7ALPHA-DIHYDROXY-5BETA-CHOLANIC ACID
    3A,7A-DIHYDROXY-5B-CHOLAN-24-OATE
    CDCA
    3A,7A-DIHYDROXY-5B-CHOLANATE
    7A-HYDROXY-DESOXYCHOLSAEURE
    CHENOCHOLIC ACID
    3A,7A-DIHYDROXY-5B,14A,17B-CHOLANATE
    (+)-CHENODEOXYCHOLATE
    drugbank:06777
    chemidplus:474-25-9
    rxcui:2323
    pubchem.compound:10133
    chembl:CHEMBL240597

    Drug Info:

    (0 More Sources)

    Publications:

    Yu BZ et al., 2009, Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia., J Nat Prod
    Katona BW et al., 2007, Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids., J Med Chem
    Sepe V et al., 2014, Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)., J Med Chem
    Gioiello A et al., 2011, Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine., Bioorg Med Chem
    Schuster D et al., 2011, Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation., Bioorg Med Chem
    Grienke U et al., 2011, Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum., Bioorg Med Chem
    Sepe V et al., 2012, Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei., J Med Chem
    Sepe V et al., 2011, Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor., J Med Chem
    Festa C et al., 2014, Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands., J Med Chem
    D'Amore C et al., 2014, Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors., J Med Chem
  • CHENODIOL   GPBAR1

    Interaction Score: 5.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25162837 17963371


    Sources:
    DTC

  • CHENODIOL   ABCB11

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19102680


    Sources:
    DTC

  • CHENODIOL   NR1H4

    Interaction Score: 1.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Bile acid receptor FXR agonist
    Direct Interaction yes

    PMIDs:
    21459580 17963371 22018919 25162837 22014750 22126372 21309576 25247751 24387325


    Sources:
    DTC ChemblInteractions TTD

  • CHENODIOL   PLA2G1B

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19102680


    Sources:
    DTC

  • CHENODIOL   NR1I2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17963371


    Sources:
    DTC

  • CHENODIOL   TARDBP

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHENODIOL   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DTC: CHENODIOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL240597 ChEMBL Drug ID

    Drug Info:

    Publications:
    Yu BZ et al., 2009, Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia., J Nat Prod
    Sepe V et al., 2014, Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)., J Med Chem
    Katona BW et al., 2007, Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids., J Med Chem

  • TTD: Chenodiol

    • Version: 2020.06.01

    Alternate Names:
    D03ZTE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL240597

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL240597

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21