DGIdb - CHENODIOL Drug Record

CHENODIOL chembl:CHEMBL240597 Approved

Alternate Names:

CHENODIOL
CHENIC ACID
CHENOFALK
CHENODEOXYCHOLIC ACID
CHENOCEDON
XENBILOX
CHENIX
COMBIDOL
LITHOFALK
CHENDOL 250
NSC-657949
CHENDOL 125
CHENODEOXYCHOLATE
7ALPHA-HYDROXYLITHOCHOLIC ACID
(3A,5B,7A)-3,7-DIHYDROXY-CHOLAN-24-OATE
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-DIHYDROXY-10,13-DIMETHYL-2,3,4,5,6,7,8,9,11,12,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOIC ACID
(+)-CHENODEOXYCHOLIC ACID
CHENODESOXYCHOLSAEURE
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-DIMETHYL-3,7-BIS(OXIDANYL)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOIC ACID
3A,7A-DIHYDROXY-5B-CHOLAN-24-OIC ACID
3A,7A-DIHYDROXY-5B-CHOLANIC ACID
3A,7A-DIHYDROXY-5B,14A,17B-CHOLANIC ACID
ANTHROPODEOXYCHOLIC ACID
CHENODESOXYCHOLIC ACID
(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-DIHYDROXY-2,15-DIMETHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECAN-14-YL]PENTANOIC ACID
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-DIHYDROXY-10,13-DIMETHYL-2,3,4,5,6,7,8,9,11,12,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]VALERIC ACID
GALLODESOXYCHOLIC ACID
ANTHROPODESOXYCHOLIC ACID
CHENODIOL®
(3A,5B,7A)-3,7-DIHYDROXY-CHOLAN-24-OIC ACID
CHENIX®
3ALPHA,7ALPHA-DIHYDROXY-5BETA-CHOLANIC ACID
3A,7A-DIHYDROXY-5B-CHOLAN-24-OATE
CDCA
3A,7A-DIHYDROXY-5B-CHOLANATE
7A-HYDROXY-DESOXYCHOLSAEURE
CHENOCHOLIC ACID
3A,7A-DIHYDROXY-5B,14A,17B-CHOLANATE
(+)-CHENODEOXYCHOLATE
drugbank:06777
chemidplus:474-25-9
rxcui:2323
pubchem.compound:10133
chembl:CHEMBL240597

Drug Info:

(0 More Sources)

Publications:

Yu BZ et al., 2009, Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia., J Nat Prod
Katona BW et al., 2007, Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids., J Med Chem
Sepe V et al., 2014, Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)., J Med Chem
Gioiello A et al., 2011, Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine., Bioorg Med Chem
Schuster D et al., 2011, Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation., Bioorg Med Chem
Grienke U et al., 2011, Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum., Bioorg Med Chem
Sepe V et al., 2012, Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei., J Med Chem
Sepe V et al., 2011, Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor., J Med Chem
Festa C et al., 2014, Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands., J Med Chem
D'Amore C et al., 2014, Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors., J Med Chem

CHENODIOL GPBAR1

Interaction Score: 5.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25162837 17963371

Sources:
DTC
CHENODIOL ABCB11

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19102680

Sources:
DTC
CHENODIOL NR1H4

Interaction Score: 1.63

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Bile acid receptor FXR agonist

Direct Interaction yes

PMIDs:
21459580 17963371 22018919 25162837 22014750 22126372 21309576 25247751 24387325

Sources:
DTC ChemblInteractions TTD
CHENODIOL PLA2G1B

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19102680

Sources:
DTC
CHENODIOL NR1I2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17963371

Sources:
DTC
CHENODIOL TARDBP

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHENODIOL AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: CHENODIOL

Version: 02-September-2020

Alternate Names:

CHEMBL240597 ChEMBL Drug ID

Drug Info:

Publications:

Yu BZ et al., 2009, Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia., J Nat Prod

Sepe V et al., 2014, Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)., J Med Chem

Katona BW et al., 2007, Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids., J Med Chem

TTD: Chenodiol
- Version: 2020.06.01
Alternate Names:

D03ZTE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL240597
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL240597
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Bile acid receptor FXR agonist
Direct Interaction	yes

CHENODIOL Drug Record

CHENODIOL chembl:CHEMBL240597 Approved

Alternate Names:

Drug Info:

Publications:

CHENODIOL GPBAR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25162837 17963371

Sources: DTC

CHENODIOL ABCB11

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19102680

Sources: DTC

CHENODIOL NR1H4

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Bile acid receptor FXR agonist Direct Interaction yes

PMIDs: 21459580 17963371 22018919 25162837 22014750 22126372 21309576 25247751 24387325

Sources: DTC ChemblInteractions TTD

CHENODIOL PLA2G1B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19102680

Sources: DTC

CHENODIOL NR1I2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17963371

Sources: DTC

CHENODIOL TARDBP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

CHENODIOL AR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DTC: CHENODIOL

Alternate Names: CHEMBL240597 ChEMBL Drug ID

Drug Info:

TTD: Chenodiol

Alternate Names: D03ZTE TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL240597

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL240597

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
25162837 17963371

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19102680

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Bile acid receptor FXR agonist

Direct Interaction yes

PMIDs:
21459580 17963371 22018919 25162837 22014750 22126372 21309576 25247751 24387325

Sources:
DTC ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
19102680

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17963371

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHEMBL240597 ChEMBL Drug ID

Alternate Names:

D03ZTE TTD Drug ID