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CHLOROGUANIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • CHLOROGUANIDE chembl:CHEMBL1377 Approved

    Alternate Names:

    CHLORGUANIDE
    PROGUANIL
    CHLOROGUANIDE
    N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
    1-(P-CHLOROPHENYL)-5-ISOPROPYLBIGUANIDE
    pubchem.compound:6178111
    chemidplus:500-92-5
    chembl:CHEMBL1377
    drugbank:01131
    rxcui:2382

    Drug Info:

    (0 More Sources)

    Publications:

    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Matthaei J et al., 2019, OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil., Clin Pharmacol Ther
    Kaneko A et al., 1999, Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations., Pharmacogenetics
  • CHLOROGUANIDE   PDF

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHLOROGUANIDE   SLC22A1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29882324


    Sources:
    PharmGKB

  • CHLOROGUANIDE   CYP2C19

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10471063


    Sources:
    PharmGKB

  • CHLOROGUANIDE   CYP3A4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • PharmGKB: proguanil

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Matthaei J et al., 2019, OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil., Clin Pharmacol Ther
    Kaneko A et al., 1999, Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations., Pharmacogenetics
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Proguanil

    • Version: 2020.06.01

    Alternate Names:
    D0P8RS TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1377

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21