DGIdb - CHLOROQUINE Drug Record

CHLOROQUINE chembl:CHEMBL76 Approved

Alternate Names:

ARALEN
CHLOROQUINE
NSC-187208
CHLOROCHINE
CHLOROQUINA
CHLOROQUINUM
CHLOROCHIN
N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIETHYL-1,4-PENTANEDIAMINE
CLOROQUINA
ARALEN®
MALAQUIN®
CHLOROQUINIUM
N(4)-(7-CHLORO-4-QUINOLINYL)-N(1),N(1)-DIETHYL-1,4-PENTANEDIAMINE
CHLORAQUINE
7-CHLORO-4-{[4-(DIETHYLAMINO)-1-METHYLBUTYL]AMINO}QUINOLINIUM
pubchem.compound:2719
chembl:CHEMBL76
drugbank:00608
chemidplus:54-05-7
rxcui:2393

Drug Info:

(1 More Sources)

Publications:

Martinson JA et al., 2010, Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation., Antimicrob Agents Chemother
Merrell et al., 2006, Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity., Mol. Cancer Res.
Rutz et al., 2004, Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner., Eur. J. Immunol.
Lenert, 2005, Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases?, Clin. Exp. Immunol.
Trevani et al., 2003, Bacterial DNA activates human neutrophils by a CpG-independent pathway., Eur. J. Immunol.
Huang et al., 2005, Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9., J. Immunol.
Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Shukla NM et al., 2012, Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines., J Med Chem

CHLOROQUINE ASS1

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27735949

Sources:
CIViC
CHLOROQUINE ACKR1

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHLOROQUINE TLR9

Interaction Score: 2.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19949061 16849519 15307186 15762869 14579285 16148144

Sources:
DTC
CHLOROQUINE TLR7

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22239408 19949061

Sources:
DTC
CHLOROQUINE G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
CHLOROQUINE CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLOROQUINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLOROQUINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLOROQUINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLOROQUINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLOROQUINE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: CHLOROQUINE

Version: 02-September-2020

Alternate Names:

CHEMBL76 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Martinson JA et al., 2010, Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation., Antimicrob Agents Chemother

Shukla NM et al., 2012, Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines., J Med Chem

CIViC: CHLOROQUINE
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis
TTD: Chloroquine
- Version: 2020.06.01
Alternate Names:

D09EGZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL76
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Chloroquine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

CHLOROQUINE Drug Record

CHLOROQUINE chembl:CHEMBL76 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27735949

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19949061 16849519 15307186 15762869 14579285 16148144

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22239408 19949061

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DTC: CHLOROQUINE

Alternate Names: CHEMBL76 ChEMBL Drug ID

Drug Info:

CIViC: CHLOROQUINE

Alternate Names:

Drug Info:

Publications: Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis

TTD: Chloroquine

Alternate Names: D09EGZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL76

Alternate Names:

Drug Info:

Publications:

FDA: Chloroquine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
27735949

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19949061 16849519 15307186 15762869 14579285 16148144

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22239408 19949061

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHEMBL76 ChEMBL Drug ID

Publications:

Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis

Alternate Names:

D09EGZ TTD Drug ID