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CHLOROQUINE Drug Record

  • Summary
  • Interactions
  • Claims
  • CHLOROQUINE chembl:CHEMBL76 Approved

    Alternate Names:

    ARALEN
    CHLOROQUINE
    NSC-187208
    CHLOROCHINE
    CHLOROQUINA
    CHLOROQUINUM
    CHLOROCHIN
    N4-(7-CHLORO-4-QUINOLINYL)-N1,N1-DIETHYL-1,4-PENTANEDIAMINE
    CLOROQUINA
    ARALEN®
    MALAQUIN®
    CHLOROQUINIUM
    N(4)-(7-CHLORO-4-QUINOLINYL)-N(1),N(1)-DIETHYL-1,4-PENTANEDIAMINE
    CHLORAQUINE
    7-CHLORO-4-{[4-(DIETHYLAMINO)-1-METHYLBUTYL]AMINO}QUINOLINIUM
    pubchem.compound:2719
    chembl:CHEMBL76
    drugbank:00608
    chemidplus:54-05-7
    rxcui:2393

    Drug Info:

    (1 More Sources)

    Publications:

    Martinson JA et al., 2010, Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation., Antimicrob Agents Chemother
    Merrell et al., 2006, Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity., Mol. Cancer Res.
    Rutz et al., 2004, Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner., Eur. J. Immunol.
    Lenert, 2005, Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases?, Clin. Exp. Immunol.
    Trevani et al., 2003, Bacterial DNA activates human neutrophils by a CpG-independent pathway., Eur. J. Immunol.
    Huang et al., 2005, Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9., J. Immunol.
    Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Shukla NM et al., 2012, Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines., J Med Chem
  • CHLOROQUINE   ASS1

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27735949


    Sources:
    CIViC

  • CHLOROQUINE   ACKR1

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHLOROQUINE   TLR9

    Interaction Score: 2.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19949061 16849519 15307186 15762869 14579285 16148144


    Sources:
    DTC

  • CHLOROQUINE   TLR7

    Interaction Score: 1.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22239408 19949061


    Sources:
    DTC

  • CHLOROQUINE   G6PD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • CHLOROQUINE   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CHLOROQUINE   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CHLOROQUINE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CHLOROQUINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CHLOROQUINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CHLOROQUINE   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DTC: CHLOROQUINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL76 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Martinson JA et al., 2010, Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation., Antimicrob Agents Chemother
    Shukla NM et al., 2012, Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines., J Med Chem

  • CIViC: CHLOROQUINE

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis

  • TTD: Chloroquine

    • Version: 2020.06.01

    Alternate Names:
    D09EGZ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL76

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Chloroquine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21