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CHLORPROMAZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • CHLORPROMAZINE chembl:CHEMBL71 Approved

    Alternate Names:

    CHLORPROMAZINE TANNATE
    LARGACTIL
    MEGAPHEN
    CHLORPROMAZINE HIBENZATE
    SONAZINE
    SKF-2601A
    J2.794D
    CHLORPROMAZINE PHENOLPHTHALINATE
    NSC-167745
    ELMARIN
    CHLORPROMAZINE
    THORAZINE
    NSC-226514
    3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)-N,N-DIMETHYL-1-PROPANAMINE
    N-(3-DIMETHYLAMINOPROPYL)-3-CHLOROPHENOTHIAZINE
    CPZ
    LARGACTIL®
    3-(2-CHLOROPHENOTHIAZIN-10-YL)-N,N-DIMETHYL-PROPAN-1-AMINE
    CHLORPROMAZINE HCL
    THORAZINE®
    rxcui:2403
    chemidplus:50-53-3
    drugbank:00477
    chembl:CHEMBL71
    pubchem.compound:2726

    Drug Info:

    (2 More Sources)

    Publications:

    Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
    Kusumi et al., 2000, Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain., J Neural Transm (Vienna)
    Yamada et al., 1995, Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice., Biol. Pharm. Bull.
    Xu et al., 2008, BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population., Pharmacogenet. Genomics
    Roth et al., 1995, D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs., Psychopharmacology (Berl.)
    Oades et al., 2000, Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy., Behav Pharmacol
    Wu et al., 2006, Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients., Acta Pharmacol. Sin.
    Seeman, 2010, Dopamine D2 receptors as treatment targets in schizophrenia., Clin Schizophr Relat Psychoses
    Wu et al., 2005, Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients., Neurosci. Lett.
    Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Arranz MJ et al., 1998, Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response., Pharmacogenetics
    Ohara K et al., 1998, Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia., Psychiatry Res
    Eum S et al., 2017, Pharmacogenetic evaluation to assess breakthrough psychosis with aripiprazole long-acting injection: a case report., BMC Psychiatry
    Zhang JP et al., 2010, D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis., Am J Psychiatry
    Shen YC et al., 2009, Effects of DRD2/ANKK1 gene variations and clinical factors on aripiprazole efficacy in schizophrenic patients., J Psychiatr Res
    Xing Q et al., 2007, The relationship between the therapeutic response to risperidone and the dopamine D2 receptor polymorphism in Chinese schizophrenia patients., Int J Neuropsychopharmacol
    Lencz et al., 2006, DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients., Am J Psychiatry
    Hwang R et al., 2005, Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations., Psychopharmacology (Berl)
    Suzuki A et al., 2001, The -141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter region is associated with anxiolytic and antidepressive effects during treatment with dopamine antagonists in schizophrenic patients., Pharmacogenetics
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Tay JK et al., 2007, Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia., Prog Neuropsychopharmacol Biol Psychiatry
    Muralidharan G et al., 1996, Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine., Eur J Clin Pharmacol
    Freedman et al., 1994, Expression and pharmacological characterization of the human D3 dopamine receptor., J. Pharmacol. Exp. Ther.
    Monostory et al., 2004, Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors., Chem. Biol. Interact.
    Porcelli S et al., 2016, PDE7B, NMBR and EPM2A Variants and Schizophrenia: A Case-Control and Pharmacogenetics Study., Neuropsychobiology
    Pomeranz et al., 1987, The effect of chlorpromazine on cholecystokinin induced gallbladder contraction., Proc. West. Pharmacol. Soc.
    Giardino et al., 1990, DA2/NT receptor balance in the mesostriatal and mesolimbocortical systems after chronic treatment with typical and atypical neuroleptic drugs., Brain Res.
    Wang et al., 2008, Antipsychotic drugs inhibit the function of breast cancer resistance protein., Basic Clin. Pharmacol. Toxicol.
    Wang et al., 2006, Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein., Psychopharmacology (Berl.)
    Liu et al., 2003, Calmodulin is involved in heat shock signal transduction in wheat., Plant Physiol.
  • CHLORPROMAZINE   CCK

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3628280


    Sources:
    NCI

  • CHLORPROMAZINE   EPM2A

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27092952


    Sources:
    PharmGKB

  • CHLORPROMAZINE   NTS

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1980851


    Sources:
    NCI

  • CHLORPROMAZINE   DRD2

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    11103886 16867246 20643630 15694263 8524985 11873706 11752352 7908055 9918131 9858029 28673279 20194480 18926547 17105675 16513877 15830237 11505224


    Sources:
    ChemblInteractions PharmGKB TTD

  • CHLORPROMAZINE   CYP2E1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15135088


    Sources:
    NCI

  • CHLORPROMAZINE   HTR7

    Interaction Score: 0.26

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7908055


    Sources:
    NCI

  • CHLORPROMAZINE   HSPA4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12857801


    Sources:
    NCI

  • CHLORPROMAZINE   DRD4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction D2-like dopamine receptor antagonist

    PMIDs:
    8524985


    Sources:
    ChemblInteractions

  • CHLORPROMAZINE   HTR2A

    Interaction Score: 0.12

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    7908055 10821438 8593484


    Sources:
    ChemblInteractions

  • CHLORPROMAZINE   ABCG2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18834354


    Sources:
    NCI

  • CHLORPROMAZINE   BDNF

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18408624


    Sources:
    NCI

  • CHLORPROMAZINE   DRD3

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction D2-like dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    8301582


    Sources:
    ChemblInteractions

  • CHLORPROMAZINE   THPO

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORPROMAZINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16810505


    Sources:
    NCI PharmGKB

  • CHLORPROMAZINE   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CHLORPROMAZINE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17611010


    Sources:
    DTC PharmGKB

  • CHLORPROMAZINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8739822


    Sources:
    DTC PharmGKB

  • CHLORPROMAZINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CHLORPROMAZINE   TP53

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORPROMAZINE   IDH1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORPROMAZINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NCI: CHLORPROMAZINE

    • Version: 14-September-2017

    Alternate Names:
    C367 NCI drug code

    Drug Info:

    Publications:
    Xu et al., 2008, BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population., Pharmacogenet. Genomics
    Monostory et al., 2004, Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors., Chem. Biol. Interact.
    Wang et al., 2008, Antipsychotic drugs inhibit the function of breast cancer resistance protein., Basic Clin. Pharmacol. Toxicol.

  • DTC: CHLORPROMAZINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL71 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: chlorpromazine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Wu et al., 2005, Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients., Neurosci. Lett.
    Eum S et al., 2017, Pharmacogenetic evaluation to assess breakthrough psychosis with aripiprazole long-acting injection: a case report., BMC Psychiatry
    Suzuki A et al., 2001, The -141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter region is associated with anxiolytic and antidepressive effects during treatment with dopamine antagonists in schizophrenic patients., Pharmacogenetics

  • TTD: Chlorpromazine

    • Version: 2020.06.01

    Alternate Names:
    D01ZII TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL71

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL71

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21