DGIdb - CHLORTHALIDONE Drug Record

CHLORTHALIDONE chembl:CHEMBL1055 Approved

Alternate Names:

NSC-69200
G-33182
HYGROTON
THALITONE
CHLORTALIDONE
CHLORTHALIDONE
HYGROTON®
1-OXO-3-(3-SULFAMYL-4-CHLOROPHENYL)-3-HYDROXYISOINDOLINE
2-CHLORO-5-(1-HYDROXY-3-OXO-1-ISOINDOLINYL)BENZENESULFONAMIDE
3-(4'-CHLORO-3'-SULFAMOYLPHENYL)-3-HYDROXYPHTHALIMIDINE
2-CHLORO-5-(2,3-DIHYDRO-1-HYDROXY-3-OXO-1H-ISOINDOL-1-YL)BENZENESULFONAMIDE
CHLORPHTHALIDOLONE
PHTHALAMUDINE
PHTHALAMODINE
3-HYDROXY-3-(4-CHLORO-3-SULFAMYLPHENYL)PHTHALIMIDINE
HYT182
1-KETO-3-(3'-SULFAMYL-4'-CHLOROPHENYL)-3-HYDROXYISOINDOLINE
chembl:CHEMBL1055
drugbank:00310
chemidplus:77-36-1
rxcui:2409
pubchem.compound:2732

Drug Info:

FDA Approval	1960
Drug Class	small molecule
Drug Indications	Diuretics
Drug Indications	Antihypertensive Agents
Drug Class	antihypertensive agents
Year of Approval	1960
Drug Class	diuretics

(2 More Sources)

Publications:

Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Gamba, 2009, The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs., Am. J. Physiol. Renal Physiol.
Lynch AI et al., 2008, Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension., JAMA

CHLORTHALIDONE NPPA

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18212314

Sources:
PharmGKB
CHLORTHALIDONE SLC12A1

Interaction Score: 5.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352 19474192

Sources:
TdgClinicalTrial TEND TTD
CHLORTHALIDONE MMP3

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CHLORTHALIDONE AGT

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CHLORTHALIDONE SLC12A3

Interaction Score: 0.57

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHLORTHALIDONE ACE

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20577119

Sources:
PharmGKB

TEND: CHLORTHALIDONE
- Version: 01-August-2011
Alternate Names:

CHLORTHALIDONE Primary Drug Name

Drug Info:

Drug Class diuretics

Year of Approval 1960

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: CHLORTHALIDONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Publications:

PharmGKB: chlorthalidone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens

Lynch AI et al., 2008, Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension., JAMA

TTD: Chlorthalidone
- Version: 2020.06.01
Alternate Names:

D09NIA TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1055
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1055
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Thiazide-sensitive sodium-chloride cotransporter inhibitor
Direct Interaction	yes

Trial Name	-
Novel drug target	Established target

CHLORTHALIDONE Drug Record

CHLORTHALIDONE chembl:CHEMBL1055 Approved

Alternate Names:

Drug Info:

Publications:

CHLORTHALIDONE NPPA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18212314

Sources: PharmGKB

CHLORTHALIDONE SLC12A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352 19474192

Sources: TdgClinicalTrial TEND TTD

CHLORTHALIDONE MMP3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

CHLORTHALIDONE AGT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

CHLORTHALIDONE SLC12A3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

CHLORTHALIDONE ACE

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20577119

Sources: PharmGKB

TEND: CHLORTHALIDONE

Alternate Names: CHLORTHALIDONE Primary Drug Name

Drug Info: Drug Class diuretics Year of Approval 1960 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: CHLORTHALIDONE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Diuretics Drug Class small molecule

Publications:

PharmGKB: chlorthalidone

Alternate Names:

Drug Info:

TTD: Chlorthalidone

Alternate Names: D09NIA TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1055

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1055

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18212314

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352 19474192

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20577119

Sources:
PharmGKB

Alternate Names:

CHLORTHALIDONE Primary Drug Name

Drug Info:

Drug Class diuretics

Year of Approval 1960

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Alternate Names:

D09NIA TTD Drug ID