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CHLORTHALIDONE Drug Record

  • Summary
  • Interactions
  • Claims
  • CHLORTHALIDONE chembl:CHEMBL1055 Approved

    Alternate Names:

    NSC-69200
    G-33182
    HYGROTON
    THALITONE
    CHLORTALIDONE
    CHLORTHALIDONE
    HYGROTON®
    1-OXO-3-(3-SULFAMYL-4-CHLOROPHENYL)-3-HYDROXYISOINDOLINE
    2-CHLORO-5-(1-HYDROXY-3-OXO-1-ISOINDOLINYL)BENZENESULFONAMIDE
    3-(4'-CHLORO-3'-SULFAMOYLPHENYL)-3-HYDROXYPHTHALIMIDINE
    2-CHLORO-5-(2,3-DIHYDRO-1-HYDROXY-3-OXO-1H-ISOINDOL-1-YL)BENZENESULFONAMIDE
    CHLORPHTHALIDOLONE
    PHTHALAMUDINE
    PHTHALAMODINE
    3-HYDROXY-3-(4-CHLORO-3-SULFAMYLPHENYL)PHTHALIMIDINE
    HYT182
    1-KETO-3-(3'-SULFAMYL-4'-CHLOROPHENYL)-3-HYDROXYISOINDOLINE
    chembl:CHEMBL1055
    drugbank:00310
    chemidplus:77-36-1
    rxcui:2409
    pubchem.compound:2732

    Drug Info:

    FDA Approval 1960
    Drug Class small molecule
    Drug Indications Diuretics
    Drug Indications Antihypertensive Agents
    Drug Class antihypertensive agents
    Year of Approval 1960
    Drug Class diuretics
    (2 More Sources)

    Publications:

    Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Gamba, 2009, The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs., Am. J. Physiol. Renal Physiol.
    Lynch AI et al., 2008, Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension., JAMA
  • CHLORTHALIDONE   NPPA

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18212314


    Sources:
    PharmGKB

  • CHLORTHALIDONE   SLC12A1

    Interaction Score: 5.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 11752352 19474192


    Sources:
    TdgClinicalTrial TEND TTD

  • CHLORTHALIDONE   MMP3

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CHLORTHALIDONE   AGT

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CHLORTHALIDONE   SLC12A3

    Interaction Score: 0.57

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHLORTHALIDONE   ACE

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20577119


    Sources:
    PharmGKB

  • TEND: CHLORTHALIDONE

    • Version: 01-August-2011

    Alternate Names:
    CHLORTHALIDONE Primary Drug Name

    Drug Info:
    Drug Class diuretics
    Year of Approval 1960
    Drug Class antihypertensive agents

    Publications:

  • TdgClinicalTrial: CHLORTHALIDONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Indications Diuretics
    Drug Class small molecule

    Publications:

  • PharmGKB: chlorthalidone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
    Lynch AI et al., 2008, Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension., JAMA

  • TTD: Chlorthalidone

    • Version: 2020.06.01

    Alternate Names:
    D09NIA TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1055

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1055

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21