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CILOSTAZOL Drug Record

  • Summary
  • Interactions
  • Claims
  • CILOSTAZOL chembl:CHEMBL799 Approved

    Alternate Names:

    PLETAL
    OPC-21
    OPC-13013
    CILOSTAZOL
    6-(4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL)BUTOXY)-3,4-DIHYDRO-2(1H)-QUINOLINONE
    3,4-DIHYDRO-6-(4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL)BUTOXY)-2(1H)-QUINOLINONE
    PLETAL®
    6-[4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL)-BUTOXY]-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
    CILOSTAZOLE
    6-(4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL)BUTOXY)-3,4-DIHYDROCARBOSTYRIL
    CILOSTAZOLUM
    chemidplus:73963-72-1
    pubchem.compound:2754
    rxcui:21107
    drugbank:01166
    chembl:CHEMBL799

    Drug Info:

    FDA Approval 1999
    Drug Class small molecule
    Drug Indications Platelet Aggregation Inhibitors
    Drug Class platelet aggregation inhibitors
    Year of Approval 1999
    (4 More Sources)

    Publications:

    Schrör, 2002, The pharmacology of cilostazol., Diabetes Obes Metab
    Mokry et al., 2008, Influence of selective inhibitors of phosphodiesterase 3 and 4 on cough and airway reactivity., J. Physiol. Pharmacol.
    Hong et al., 2006, Cilostazol: therapeutic potential against focal cerebral ischemic damage., Curr. Pharm. Des.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Parkkonen et al., 2008, Phosphodiesterase 4 inhibitors delay human eosinophil and neutrophil apoptosis in the absence and presence of salbutamol., Pulm Pharmacol Ther
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Hayakawa et al., 2000, Effects of beraprost and cilostazol and renal function on serum thrombomodulin levels in diabetic patients., Arzneimittelforschung
    Wang et al., 2005, Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis., Biol. Pharm. Bull.
    Lee et al., 2001, Differential effects of cilostazol and pentoxifylline on vascular endothelial growth factor in patients with intermittent claudication., Clin. Sci.
  • CILOSTAZOL   PDE3A

    Interaction Score: 2.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 3A inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    12180353 19218671 16472148 11752352 18282775


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CILOSTAZOL   THBD

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10918946


    Sources:
    NCI

  • CILOSTAZOL   VEGFA

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11524048


    Sources:
    NCI

  • CILOSTAZOL   CSF2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15744080


    Sources:
    NCI

  • CILOSTAZOL   TSHR

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CILOSTAZOL   CYP3A5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CILOSTAZOL   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CILOSTAZOL   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CILOSTAZOL   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CILOSTAZOL   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CILOSTAZOL   ALDH1A1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CILOSTAZOL   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: CILOSTAZOL

    • Version: 01-August-2011

    Alternate Names:
    CILOSTAZOL Primary Drug Name

    Drug Info:
    Year of Approval 1999
    Drug Class platelet aggregation inhibitors

    Publications:

  • TdgClinicalTrial: CILOSTAZOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Platelet Aggregation Inhibitors
    Drug Class small molecule
    FDA Approval 1999

    Publications:

  • NCI: CILOSTAZOL

    • Version: 14-September-2017

    Alternate Names:
    C1051 NCI drug code

    Drug Info:

    Publications:
    Lee et al., 2001, Differential effects of cilostazol and pentoxifylline on vascular endothelial growth factor in patients with intermittent claudication., Clin. Sci.
    Wang et al., 2005, Inhibition of eosinophil survival by a selective inhibitor of phosphodiesterase 4 via the induction of apoptosis., Biol. Pharm. Bull.
    Hayakawa et al., 2000, Effects of beraprost and cilostazol and renal function on serum thrombomodulin levels in diabetic patients., Arzneimittelforschung

  • DTC: CILOSTAZOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL799 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Cilostazol

    • Version: 2020.06.01

    Alternate Names:
    D03VPC TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL799

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL799

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: cilostazol

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21