DGIdb - CIMETIDINE Drug Record

CIMETIDINE chembl:CHEMBL30 Approved

Alternate Names:

PEPTIMAX 800
SKF-92334
KENTAMET
TAGAMET
ACITAK 200
DYSPAMET
NSC-335308
ACITAK 800
TAGAMET 100
TAGAMET HB 200
BRUMETADINA
TAGADINE
ZITA
ACID-EZE
ULTEC
GALENAMET
VALMAGEN
CIMETIDINE
PEPTIMAX 200
TAGAMET HB
PEPTIMAX 400
ACITAK 400
N''-CYANO-N-METHYL-N'-(2-{[(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]THIO}ETHYL)GUANIDINE
TAGAMET®
2-CYANO-1-METHYL-3-(2-(((5-METHYLIMIDAZOL-4-YL)METHYL)THIO)ETHYL)GUANIDINE
CIMETIDIN
CIMETIDINA
CIMETIDINUM
N-CYANO-N'-METHYL-N''-(2-([(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]SULFANYL)ETHYL)GUANIDINE
ULCERFEN
CIMETAG
CIMÉTIDINE
CIMETIDINE HCL
1-CYANO-2-METHYL-3-(2-(((5-METHYL-4-IMIDAZOLYL)METHYL)THIO)ETHYL)GUANIDINE
rxcui:2541
drugbank:00501
pubchem.compound:2756
chembl:CHEMBL30
chemidplus:51481-61-9

Drug Info:

FDA Approval	1979
Drug Class	small molecule
Drug Indications	GI Anti-Ulcer Agents, antihistamines
Year of Approval	1979
Drug Class	gi anti-ulcer agents, antihistamines

(4 More Sources)

Publications:

Kido Y et al., 2011, Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2., J Med Chem
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Hernández-Muñoz et al., 2000, Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats., Lab. Invest.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kuint et al., 1996, Hypoxemia associated with cimetidine therapy in a newborn infant., Am J Perinatol
Takahashi et al., 2006, Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes., Mol. Pharmacol.
László et al., 2001, Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation., Inflamm. Res.
Kuo et al., 1995, Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide., Surgery

CIMETIDINE HRH2

Interaction Score: 3.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Histamine H2 receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
10950107 11752352 8863950 16723495

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
CIMETIDINE SLC22A2

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21599003

Sources:
DTC
CIMETIDINE FCGR3A

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11556524

Sources:
NCI
CIMETIDINE NOS1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7543704

Sources:
NCI
CIMETIDINE CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC PharmGKB
CIMETIDINE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CIMETIDINE POLK

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CIMETIDINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CIMETIDINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CIMETIDINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: CIMETIDINE
- Version: 01-August-2011
Alternate Names:

CIMETIDINE Primary Drug Name

Drug Info:

Drug Class gi anti-ulcer agents, antihistamines

Year of Approval 1979

Publications:
TdgClinicalTrial: CIMETIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications GI Anti-Ulcer Agents, antihistamines

Drug Class small molecule

FDA Approval 1979

Publications:

DTC: CIMETIDINE

Version: 02-September-2020

Alternate Names:

CHEMBL30 ChEMBL Drug ID

Drug Info:

Publications:

Kido Y et al., 2011, Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2., J Med Chem

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

NCI: CIMETIDINE

Version: 14-September-2017

Alternate Names:

C374 NCI drug code

Drug Info:

Publications:

Kuo et al., 1995, Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide., Surgery

László et al., 2001, Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation., Inflamm. Res.

TTD: Cimetidine
- Version: 2020.06.01
Alternate Names:

D02DPA TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL30
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL30
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: cimetidine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Histamine H2 receptor antagonist
Direct Interaction	yes
Trial Name	-

CIMETIDINE Drug Record

CIMETIDINE chembl:CHEMBL30 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Histamine H2 receptor antagonist Direct Interaction yes Trial Name -

PMIDs: 10950107 11752352 8863950 16723495

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21599003

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11556524

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7543704

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: CIMETIDINE

Alternate Names: CIMETIDINE Primary Drug Name

Drug Info: Drug Class gi anti-ulcer agents, antihistamines Year of Approval 1979

Publications:

TdgClinicalTrial: CIMETIDINE

Alternate Names:

Drug Info: Drug Indications GI Anti-Ulcer Agents, antihistamines Drug Class small molecule FDA Approval 1979

Publications:

DTC: CIMETIDINE

Alternate Names: CHEMBL30 ChEMBL Drug ID

Drug Info:

NCI: CIMETIDINE

Alternate Names: C374 NCI drug code

Drug Info:

TTD: Cimetidine

Alternate Names: D02DPA TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL30

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL30

Alternate Names:

Drug Info:

Publications:

PharmGKB: cimetidine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Histamine H2 receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
10950107 11752352 8863950 16723495

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
21599003

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11556524

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7543704

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

CIMETIDINE Primary Drug Name

Drug Info:

Drug Class gi anti-ulcer agents, antihistamines

Year of Approval 1979

Drug Info:

Drug Indications GI Anti-Ulcer Agents, antihistamines

Drug Class small molecule

FDA Approval 1979

Alternate Names:

CHEMBL30 ChEMBL Drug ID

Alternate Names:

C374 NCI drug code

Alternate Names:

D02DPA TTD Drug ID