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CIMETIDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • CIMETIDINE chembl:CHEMBL30 Approved

    Alternate Names:

    PEPTIMAX 800
    SKF-92334
    KENTAMET
    TAGAMET
    ACITAK 200
    DYSPAMET
    NSC-335308
    ACITAK 800
    TAGAMET 100
    TAGAMET HB 200
    BRUMETADINA
    TAGADINE
    ZITA
    ACID-EZE
    ULTEC
    GALENAMET
    VALMAGEN
    CIMETIDINE
    PEPTIMAX 200
    TAGAMET HB
    PEPTIMAX 400
    ACITAK 400
    N''-CYANO-N-METHYL-N'-(2-{[(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]THIO}ETHYL)GUANIDINE
    TAGAMET®
    2-CYANO-1-METHYL-3-(2-(((5-METHYLIMIDAZOL-4-YL)METHYL)THIO)ETHYL)GUANIDINE
    CIMETIDIN
    CIMETIDINA
    CIMETIDINUM
    N-CYANO-N'-METHYL-N''-(2-([(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]SULFANYL)ETHYL)GUANIDINE
    ULCERFEN
    CIMETAG
    CIMÉTIDINE
    CIMETIDINE HCL
    1-CYANO-2-METHYL-3-(2-(((5-METHYL-4-IMIDAZOLYL)METHYL)THIO)ETHYL)GUANIDINE
    rxcui:2541
    drugbank:00501
    pubchem.compound:2756
    chembl:CHEMBL30
    chemidplus:51481-61-9

    Drug Info:

    FDA Approval 1979
    Drug Class small molecule
    Drug Indications GI Anti-Ulcer Agents, antihistamines
    Year of Approval 1979
    Drug Class gi anti-ulcer agents, antihistamines
    (4 More Sources)

    Publications:

    Kido Y et al., 2011, Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2., J Med Chem
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Hernández-Muñoz et al., 2000, Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats., Lab. Invest.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kuint et al., 1996, Hypoxemia associated with cimetidine therapy in a newborn infant., Am J Perinatol
    Takahashi et al., 2006, Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes., Mol. Pharmacol.
    László et al., 2001, Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation., Inflamm. Res.
    Kuo et al., 1995, Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide., Surgery
  • CIMETIDINE   HRH2

    Interaction Score: 3.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histamine H2 receptor antagonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    10950107 11752352 8863950 16723495


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CIMETIDINE   SLC22A2

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21599003


    Sources:
    DTC

  • CIMETIDINE   FCGR3A

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11556524


    Sources:
    NCI

  • CIMETIDINE   NOS1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7543704


    Sources:
    NCI

  • CIMETIDINE   CYP2C19

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC PharmGKB

  • CIMETIDINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CIMETIDINE   POLK

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CIMETIDINE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CIMETIDINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CIMETIDINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: CIMETIDINE

    • Version: 01-August-2011

    Alternate Names:
    CIMETIDINE Primary Drug Name

    Drug Info:
    Drug Class gi anti-ulcer agents, antihistamines
    Year of Approval 1979

    Publications:

  • TdgClinicalTrial: CIMETIDINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications GI Anti-Ulcer Agents, antihistamines
    Drug Class small molecule
    FDA Approval 1979

    Publications:

  • DTC: CIMETIDINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL30 ChEMBL Drug ID

    Drug Info:

    Publications:
    Kido Y et al., 2011, Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2., J Med Chem
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • NCI: CIMETIDINE

    • Version: 14-September-2017

    Alternate Names:
    C374 NCI drug code

    Drug Info:

    Publications:
    Kuo et al., 1995, Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide., Surgery
    László et al., 2001, Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation., Inflamm. Res.

  • TTD: Cimetidine

    • Version: 2020.06.01

    Alternate Names:
    D02DPA TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL30

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL30

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: cimetidine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21