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CINOLAZEPAM Drug Record

  • Summary
  • Interactions
  • Claims
  • CINOLAZEPAM chembl:CHEMBL2104926

    Alternate Names:

    CINOLAZEPAM
    1-(2-CYANOETHYL)-7-CHLORO-3-HYDROXY-5-(2'-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE
    7-CHLORO-5-(O-FLUOROPHENYL)-2,3-DIHYDRO-3-HYDROXY-2-OXO-1H-1,4-BENZODIAZEPINE-1-PROPIONITRILE
    CINOLAZEPAMUM
    7-CHLORO-5-(2-FLUOROPHENYL)-2,3-DIHYDRO-3-HYDROXY-2-OXO-1H-1,4-BENZODIAZEPINE-1-PROPANENITRILE
    pubchem.compound:3033621
    drugbank:01594
    chemidplus:75696-02-5
    chembl:CHEMBL2104926

    Drug Info:

    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    Year of Approval not approved by the fda
    Drug Class hypnotics and sedatives
    Drug Groups experimental
    Drug Categories benzodiazepine hypnotics and sedatives
    Drug Categories benzodiazepines and benzodiazepine derivatives
    Drug Categories central nervous system depressants
    Drug Categories heterocyclic compounds, fused-ring
    (1 More Sources)

    Publications:

    Amin et al., 1997, Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors., Mol. Pharmacol.
    Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
    Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
    Walash et al., 1994, A selective fluorimetric method for the determination of some 1,4-benzodiazepine drugs containing a hydroxyl group at C-3., J Pharm Biomed Anal
  • CINOLAZEPAM   GABRR3

    Interaction Score: 0.35

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRR2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRE

    Interaction Score: 0.16

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRP

    Interaction Score: 0.16

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRD

    Interaction Score: 0.16

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRG1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRA1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9145922 29950725 23038269


    Sources:
    TEND TdgClinicalTrial DrugBank

  • CINOLAZEPAM   GABRB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRB3

    Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRG3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRA5

    Interaction Score: 0.12

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRA2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   GABRA3

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7849137


    Sources:
    TEND TdgClinicalTrial

  • CINOLAZEPAM   TSPO

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CINOLAZEPAM   GABRG2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    7849137


    Sources:
    TEND

  • DrugBank: DB01594

    • Version: 5.1.7

    Alternate Names:
    CINOLAZEPAM DrugBank Drug Name
    75696-02-5 CAS Number
    Gerodorm Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups experimental
    Drug Categories benzazepines

    Publications:
    Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
    Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem

  • TEND: CINOLAZEPAM

    • Version: 01-August-2011

    Alternate Names:
    CINOLAZEPAM Primary Drug Name

    Drug Info:
    Drug Class hypnotics and sedatives
    Year of Approval not approved by the fda

    Publications:

  • TdgClinicalTrial: CINOLAZEPAM

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule
    FDA Approval not approved by the FDA

    Publications:

  • TTD: Cinolazepam

    • Version: 2020.06.01

    Alternate Names:
    D0Q9WO TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL2104926

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13