DGIdb - CLARITHROMYCIN Drug Record

CLARITHROMYCIN chembl:CHEMBL1741 Approved

Alternate Names:

BIAXIN
BIAXIN XL PAC
MYCIFOR XL
KLARICID ADULT
FEBZIN XL
ABBOTT-56268
BIAXIN XL
KLARICID I.V.
PREVPAC
CLAROSIP
XETININ XL
KLARICID 500
KLARICID XL
KLARICID PAED
A-56268
CLARITHROMYCIN
CLARIE XL
CLARITHROMYCIN EXTENDED RELEASE
ZECLAR
KLARICID
CLARITHROMYCIN IDENTITY
TE-031
CLARITHROMYCINA
6-O-METHYLERYTHROMYCIN
CLA
6-O-METHYLERYTHROMYCIN A
CLARITHROMYCINE
CLARITHROMYCINUM
6-O-METHYL ERYTHROMYCIN
pubchem.compound:84029
rxcui:21212
chembl:CHEMBL1741
chemidplus:81103-11-9
drugbank:01211

Drug Info:

(1 More Sources)

Publications:

Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Quinney et al., 2008, Interaction between midazolam and clarithromycin in the elderly., Br J Clin Pharmacol
Desta Z et al., 1999, Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)., Clin Pharmacol Ther
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Enomoto et al., 2002, Effect of new macrolides on the expression of adhesion molecules on neutrophils in chronic sinusitis., Auris Nasus Larynx
Gurley et al., 2006, Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans., Drug Metab. Dispos.
Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.
Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.
Kikuchi et al., 2002, Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors., J. Antimicrob. Chemother.

CLARITHROMYCIN F2RL1

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18212111

Sources:
DTC
CLARITHROMYCIN ITGAM

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12167449

Sources:
NCI
CLARITHROMYCIN IL10

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16815316

Sources:
NCI
CLARITHROMYCIN XDH

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14730107

Sources:
NCI
CLARITHROMYCIN NOS1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14730107

Sources:
NCI
CLARITHROMYCIN CXCL8

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12003967

Sources:
NCI
CLARITHROMYCIN CYP3A5

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
CLARITHROMYCIN ABCB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16221754

Sources:
NCI PharmGKB
CLARITHROMYCIN CYP3A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17635500 9951426 9187528

Sources:
NCI PharmGKB
CLARITHROMYCIN CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLARITHROMYCIN CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLARITHROMYCIN CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLARITHROMYCIN CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

NCI: CLARITHROMYCIN

Version: 14-September-2017

Alternate Names:

C1054 NCI drug code

Drug Info:

Publications:

Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol

Enomoto et al., 2002, Effect of new macrolides on the expression of adhesion molecules on neutrophils in chronic sinusitis., Auris Nasus Larynx

Quinney et al., 2008, Interaction between midazolam and clarithromycin in the elderly., Br J Clin Pharmacol

DTC: CLARITHROMYCIN

Version: 02-September-2020

Alternate Names:

CHEMBL1741 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.

PharmGKB: clarithromycin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Desta Z et al., 1999, Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)., Clin Pharmacol Ther

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Clarithromycin
- Version: 2020.06.01
Alternate Names:

D0Z1ZM TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1741
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

CLARITHROMYCIN Drug Record

CLARITHROMYCIN chembl:CHEMBL1741 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18212111

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12167449

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16815316

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14730107

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14730107

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12003967

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16221754

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17635500 9951426 9187528

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

NCI: CLARITHROMYCIN

Alternate Names: C1054 NCI drug code

Drug Info:

DTC: CLARITHROMYCIN

Alternate Names: CHEMBL1741 ChEMBL Drug ID

Drug Info:

PharmGKB: clarithromycin

Alternate Names:

Drug Info:

TTD: Clarithromycin

Alternate Names: D0Z1ZM TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1741

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18212111

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12167449

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16815316

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14730107

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14730107

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12003967

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16221754

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17635500 9951426 9187528

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

C1054 NCI drug code

Alternate Names:

CHEMBL1741 ChEMBL Drug ID

Alternate Names:

D0Z1ZM TTD Drug ID