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CLARITHROMYCIN Drug Record

  • Summary
  • Interactions
  • Claims
  • CLARITHROMYCIN chembl:CHEMBL1741 Approved

    Alternate Names:

    BIAXIN
    BIAXIN XL PAC
    MYCIFOR XL
    KLARICID ADULT
    FEBZIN XL
    ABBOTT-56268
    BIAXIN XL
    KLARICID I.V.
    PREVPAC
    CLAROSIP
    XETININ XL
    KLARICID 500
    KLARICID XL
    KLARICID PAED
    A-56268
    CLARITHROMYCIN
    CLARIE XL
    CLARITHROMYCIN EXTENDED RELEASE
    ZECLAR
    KLARICID
    CLARITHROMYCIN IDENTITY
    TE-031
    CLARITHROMYCINA
    6-O-METHYLERYTHROMYCIN
    CLA
    6-O-METHYLERYTHROMYCIN A
    CLARITHROMYCINE
    CLARITHROMYCINUM
    6-O-METHYL ERYTHROMYCIN
    pubchem.compound:84029
    rxcui:21212
    chembl:CHEMBL1741
    chemidplus:81103-11-9
    drugbank:01211

    Drug Info:

    (1 More Sources)

    Publications:

    Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Quinney et al., 2008, Interaction between midazolam and clarithromycin in the elderly., Br J Clin Pharmacol
    Desta Z et al., 1999, Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)., Clin Pharmacol Ther
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Enomoto et al., 2002, Effect of new macrolides on the expression of adhesion molecules on neutrophils in chronic sinusitis., Auris Nasus Larynx
    Gurley et al., 2006, Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans., Drug Metab. Dispos.
    Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.
    Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.
    Kikuchi et al., 2002, Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors., J. Antimicrob. Chemother.
  • CLARITHROMYCIN   F2RL1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18212111


    Sources:
    DTC

  • CLARITHROMYCIN   ITGAM

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12167449


    Sources:
    NCI

  • CLARITHROMYCIN   IL10

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16815316


    Sources:
    NCI

  • CLARITHROMYCIN   XDH

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14730107


    Sources:
    NCI

  • CLARITHROMYCIN   NOS1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14730107


    Sources:
    NCI

  • CLARITHROMYCIN   CXCL8

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12003967


    Sources:
    NCI

  • CLARITHROMYCIN   CYP3A5

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • CLARITHROMYCIN   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16221754


    Sources:
    NCI PharmGKB

  • CLARITHROMYCIN   CYP3A4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17635500 9951426 9187528


    Sources:
    NCI PharmGKB

  • CLARITHROMYCIN   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CLARITHROMYCIN   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CLARITHROMYCIN   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CLARITHROMYCIN   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NCI: CLARITHROMYCIN

    • Version: 14-September-2017

    Alternate Names:
    C1054 NCI drug code

    Drug Info:

    Publications:
    Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol
    Enomoto et al., 2002, Effect of new macrolides on the expression of adhesion molecules on neutrophils in chronic sinusitis., Auris Nasus Larynx
    Quinney et al., 2008, Interaction between midazolam and clarithromycin in the elderly., Br J Clin Pharmacol

  • DTC: CLARITHROMYCIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1741 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.

  • PharmGKB: clarithromycin

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Desta Z et al., 1999, Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)., Clin Pharmacol Ther
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Clarithromycin

    • Version: 2020.06.01

    Alternate Names:
    D0Z1ZM TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1741

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21