DGIdb - CLEMASTINE Drug Record

CLEMASTINE chembl:CHEMBL1626 Approved

Alternate Names:

CLEMASTINE
HS-592
TAVEGIL®
MECLASTIN
CLEMASTINUM
(+)-(2R)-2-(2-(((R)-P-CHLORO-ALPHA-METHYL-ALPHA-PHENYLBENZYL)OXY)ETHYL)-1-METHYLPYRROLIDINE
TAVIST®
(+)-(2R)-2-[2-[[(R)-P-CHLORO-Α-METHYL-Α-PHENYLBENZYL]OXY]ETHYL]-1-METHYLPYRROLIDINE
CLEMASTINA
(+)-(2R)-2-(2-(((R)-P-CHLORO-Α-METHYL-Α-PHENYLBENZYL)OXY)ETHYL)-1-METHYLPYRROLIDINE
(+)-(2R)-2-[2-[[(R)-P-CHLORO-ALPHA-METHYL-ALPHA-PHENYLBENZYL]OXY]ETHYL]-1-METHYLPYRROLIDINE
drugbank:00283
chemidplus:15686-51-8
pubchem.compound:26987
chembl:CHEMBL1626
rxcui:2578

Drug Info:

Year of Approval	1977
Drug Class	anti-allergic agents
FDA Approval	1977
Drug Class	small molecule
Drug Indications	Anti-Allergic Agents

(2 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Dorsch et al., 1984, Sequential histamine inhalations cause increased bronchial histamine reactivity in guinea pigs: role of platelets, thromboxanes and prostacyclin., Naunyn Schmiedebergs Arch. Pharmacol.
Schran et al., 1996, The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations., J Clin Pharmacol
Taniguchi et al., 1991, Inhibitory effects of histamine H1 receptor blocking drugs on metabolic activations of neutrophils., J. Pharmacobio-dyn.
Taniguchi et al., 1987, [Effects of antiallergic agents on polymorphonuclear leukocytes. The inhibition of arachidonic acid release and superoxide production]., Nippon Yakurigaku Zasshi
Oishi et al., 1994, Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain., Naunyn Schmiedebergs Arch. Pharmacol.
Hallberg et al., 1984, Demonstration of histamine receptors on human platelets by flow cytometry., Scand J Haematol
Thomson et al., 1980, Effect of inhaled H1 and H2 receptor antagonist in normal and asthmatic subjects., Thorax
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hayashi et al., 1976, Atrial T (Ta) loop in dogs with or without atrial injury., Am. Heart J.
Thomas et al., 1985, The influence of ranitidine, alone and in combination with clemastine, on histamine-mediated cutaneous weal and flare reactions in human skin., Br J Clin Pharmacol

CLEMASTINE P2RX7

Interaction Score: 0.64

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLEMASTINE HRH1

Interaction Score: 0.64

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
6387510 8930778 1678430 2890562 7513381 6701456 6449094 11752352 1266718 4074605

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
CLEMASTINE THPO

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLEMASTINE CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLEMASTINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLEMASTINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLEMASTINE TP53

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLEMASTINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLEMASTINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: CLEMASTINE
- Version: 01-August-2011
Alternate Names:

CLEMASTINE Primary Drug Name

Drug Info:

Drug Class anti-allergic agents

Year of Approval 1977

Publications:
TdgClinicalTrial: CLEMASTINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Allergic Agents

Drug Class small molecule

FDA Approval 1977

Publications:
DTC: CLEMASTINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1626 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
GuideToPharmacology: 178102684
- Version: 29-September-2020
Alternate Names:

CLEMASTINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Clemastine
- Version: 2020.06.01
Alternate Names:

D0C5XC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1626
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Positive
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

CLEMASTINE Drug Record

CLEMASTINE chembl:CHEMBL1626 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: allosteric modulator

Interaction Info: Specific Action of the Ligand Positive Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 6387510 8930778 1678430 2890562 7513381 6701456 6449094 11752352 1266718 4074605

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: CLEMASTINE

Alternate Names: CLEMASTINE Primary Drug Name

Drug Info: Drug Class anti-allergic agents Year of Approval 1977

Publications:

TdgClinicalTrial: CLEMASTINE

Alternate Names:

Drug Info: Drug Indications Anti-Allergic Agents Drug Class small molecule FDA Approval 1977

Publications:

DTC: CLEMASTINE

Alternate Names: CHEMBL1626 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

GuideToPharmacology: 178102684

Alternate Names: CLEMASTINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Clemastine

Alternate Names: D0C5XC TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1626

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
6387510 8930778 1678430 2890562 7513381 6701456 6449094 11752352 1266718 4074605

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CLEMASTINE Primary Drug Name

Drug Info:

Drug Class anti-allergic agents

Year of Approval 1977

Drug Info:

Drug Indications Anti-Allergic Agents

Drug Class small molecule

FDA Approval 1977

Alternate Names:

CHEMBL1626 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

CLEMASTINE GuideToPharmacology Ligand Name

Alternate Names:

D0C5XC TTD Drug ID