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CLODRONIC ACID Drug Record

  • Summary
  • Interactions
  • Claims
  • CLODRONIC ACID chembl:CHEMBL12318 Antineoplastic

    Alternate Names:

    CLODRONIC ACID
    DICHLOROMETHYLIDENE DIPHOSPHONATE
    (DICHLOROMETHYLENE)DIPHOSPHONIC ACID
    ACIDUM CLODRONICUM
    (DICHLORO-PHOSPHONO-METHYL)-PHOSPHONIC ACID
    CLODRONSÄURE
    ACIDE CLODRONIQUE
    CLODRONATE
    DICHLOROMETHYLENE-1,1-BISPHOSPHONIC ACID
    ACIDO CLODRONICO
    CLODRONSAEURE
    DICHLOROMETHANEDIPHOSPHONIC ACID
    DICHLOROMETHYLENE-1,1-DIPHOSPHONIC ACID
    (DICHLOROMETHYLENE)BISPHOSPHONIC ACID
    rxcui:3350
    drugbank:00720
    chembl:CHEMBL12318
    pubchem.compound:25419
    chemidplus:10596-23-3

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antineoplastic agent
    (2 More Sources)

    Publications:

    Lehenkari et al., 2002, Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite., Mol. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Summan et al., 2006, Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Corral-Gudino L et al., 2006, -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone., Bone
    Madjdpour et al., 2003, Decreased alveolar oxygen induces lung inflammation., Am. J. Physiol. Lung Cell Mol. Physiol.
    Heikkilä et al., 2002, Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines., Anticancer Drugs
    Itoh et al., 2003, Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures., Eur. J. Pharmacol.
    Mossetti G et al., 2008, Vitamin D receptor gene polymorphisms predict acquired resistance to clodronate treatment in patients with Paget's disease of bone., Calcif Tissue Int
    Otrock ZK et al., 2008, Vitamin D receptor genotypes and response to zoledronic acid therapy in thalassemia-induced osteoporosis., Ann Hematol
    Palomba S et al., 2005, BsmI vitamin D receptor genotypes influence the efficacy of antiresorptive treatments in postmenopausal osteoporotic women. A 1-year multicenter, randomized and controlled trial., Osteoporos Int
    Palomba et al., 2003, Effectiveness of alendronate treatment in postmenopausal women with osteoporosis: relationship with BsmI vitamin D receptor genotypes., Clin. Endocrinol. (Oxf)
    Tofteng CL et al., 2002, Two polymorphisms in the vitamin D receptor gene--association with bone mass and 5-year change in bone mass with or without hormone-replacement therapy in postmenopausal women: the Danish Osteoporosis Prevention Study., J Bone Miner Res
    Marc J et al., 1999, VDR genotype and response to etidronate therapy in late postmenopausal women., Osteoporos Int
  • CLODRONIC ACID   SLC25A4

    Interaction Score: 24.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name clodronate,Bonefos
    Novel drug target Established target

    PMIDs:
    11961144 11752352


    Sources:
    TdgClinicalTrial TTD

  • CLODRONIC ACID   SLC25A6

    Interaction Score: 12.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name clodronate,Bonefos
    Novel drug target Established target

    PMIDs:
    11961144


    Sources:
    TdgClinicalTrial

  • CLODRONIC ACID   SLC25A5

    Interaction Score: 12.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name clodronate,Bonefos
    Novel drug target Established target

    PMIDs:
    11961144


    Sources:
    TdgClinicalTrial

  • CLODRONIC ACID   CCL4

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12388372


    Sources:
    NCI

  • CLODRONIC ACID   MYOD1

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16424086


    Sources:
    NCI

  • CLODRONIC ACID   BGLAP

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14512092


    Sources:
    NCI

  • CLODRONIC ACID   PLAU

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11984068


    Sources:
    NCI

  • CLODRONIC ACID   IL1B

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16257277


    Sources:
    PharmGKB

  • CLODRONIC ACID   PIN1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLODRONIC ACID   VDR

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19020788 18443790 15739035 12608943 12162507 10692979


    Sources:
    PharmGKB

  • TdgClinicalTrial: CLODRONATE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: CLODRONATE

    • Version: 14-September-2017

    Alternate Names:
    C1418 NCI drug code

    Drug Info:

    Publications:
    Madjdpour et al., 2003, Decreased alveolar oxygen induces lung inflammation., Am. J. Physiol. Lung Cell Mol. Physiol.
    Itoh et al., 2003, Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures., Eur. J. Pharmacol.
    Heikkilä et al., 2002, Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines., Anticancer Drugs

  • PharmGKB: clodronate

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Corral-Gudino L et al., 2006, -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone., Bone
    Marc J et al., 1999, VDR genotype and response to etidronate therapy in late postmenopausal women., Osteoporos Int
    Palomba et al., 2003, Effectiveness of alendronate treatment in postmenopausal women with osteoporosis: relationship with BsmI vitamin D receptor genotypes., Clin. Endocrinol. (Oxf)

  • TTD: Clodronate

    • Version: 2020.06.01

    Alternate Names:
    D00HNB TTD Drug ID

    Drug Info:

    Publications:

  • DTC: CLODRONIC ACID

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL12318 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL12318

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21