DGIdb - CLODRONIC ACID Drug Record

CLODRONIC ACID chembl:CHEMBL12318 Antineoplastic

Alternate Names:

CLODRONIC ACID
DICHLOROMETHYLIDENE DIPHOSPHONATE
(DICHLOROMETHYLENE)DIPHOSPHONIC ACID
ACIDUM CLODRONICUM
(DICHLORO-PHOSPHONO-METHYL)-PHOSPHONIC ACID
CLODRONSÄURE
ACIDE CLODRONIQUE
CLODRONATE
DICHLOROMETHYLENE-1,1-BISPHOSPHONIC ACID
ACIDO CLODRONICO
CLODRONSAEURE
DICHLOROMETHANEDIPHOSPHONIC ACID
DICHLOROMETHYLENE-1,1-DIPHOSPHONIC ACID
(DICHLOROMETHYLENE)BISPHOSPHONIC ACID
rxcui:3350
drugbank:00720
chembl:CHEMBL12318
pubchem.compound:25419
chemidplus:10596-23-3

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antineoplastic agent

(2 More Sources)

Publications:

Lehenkari et al., 2002, Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite., Mol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Summan et al., 2006, Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Corral-Gudino L et al., 2006, -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone., Bone
Madjdpour et al., 2003, Decreased alveolar oxygen induces lung inflammation., Am. J. Physiol. Lung Cell Mol. Physiol.
Heikkilä et al., 2002, Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines., Anticancer Drugs
Itoh et al., 2003, Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures., Eur. J. Pharmacol.
Mossetti G et al., 2008, Vitamin D receptor gene polymorphisms predict acquired resistance to clodronate treatment in patients with Paget's disease of bone., Calcif Tissue Int
Otrock ZK et al., 2008, Vitamin D receptor genotypes and response to zoledronic acid therapy in thalassemia-induced osteoporosis., Ann Hematol
Palomba S et al., 2005, BsmI vitamin D receptor genotypes influence the efficacy of antiresorptive treatments in postmenopausal osteoporotic women. A 1-year multicenter, randomized and controlled trial., Osteoporos Int
Palomba et al., 2003, Effectiveness of alendronate treatment in postmenopausal women with osteoporosis: relationship with BsmI vitamin D receptor genotypes., Clin. Endocrinol. (Oxf)
Tofteng CL et al., 2002, Two polymorphisms in the vitamin D receptor gene--association with bone mass and 5-year change in bone mass with or without hormone-replacement therapy in postmenopausal women: the Danish Osteoporosis Prevention Study., J Bone Miner Res
Marc J et al., 1999, VDR genotype and response to etidronate therapy in late postmenopausal women., Osteoporos Int

CLODRONIC ACID SLC25A4

Interaction Score: 24.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name clodronate,Bonefos

Novel drug target Established target

PMIDs:
11961144 11752352

Sources:
TdgClinicalTrial TTD
CLODRONIC ACID SLC25A6

Interaction Score: 12.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name clodronate,Bonefos

Novel drug target Established target

PMIDs:
11961144

Sources:
TdgClinicalTrial
CLODRONIC ACID SLC25A5

Interaction Score: 12.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name clodronate,Bonefos

Novel drug target Established target

PMIDs:
11961144

Sources:
TdgClinicalTrial
CLODRONIC ACID CCL4

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12388372

Sources:
NCI
CLODRONIC ACID MYOD1

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16424086

Sources:
NCI
CLODRONIC ACID BGLAP

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14512092

Sources:
NCI
CLODRONIC ACID PLAU

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11984068

Sources:
NCI
CLODRONIC ACID IL1B

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16257277

Sources:
PharmGKB
CLODRONIC ACID PIN1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLODRONIC ACID VDR

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19020788 18443790 15739035 12608943 12162507 10692979

Sources:
PharmGKB

TdgClinicalTrial: CLODRONATE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: CLODRONATE

Version: 14-September-2017

Alternate Names:

C1418 NCI drug code

Drug Info:

Publications:

Madjdpour et al., 2003, Decreased alveolar oxygen induces lung inflammation., Am. J. Physiol. Lung Cell Mol. Physiol.

Itoh et al., 2003, Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures., Eur. J. Pharmacol.

Heikkilä et al., 2002, Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines., Anticancer Drugs

PharmGKB: clodronate

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Corral-Gudino L et al., 2006, -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone., Bone

Marc J et al., 1999, VDR genotype and response to etidronate therapy in late postmenopausal women., Osteoporos Int

Palomba et al., 2003, Effectiveness of alendronate treatment in postmenopausal women with osteoporosis: relationship with BsmI vitamin D receptor genotypes., Clin. Endocrinol. (Oxf)

TTD: Clodronate
- Version: 2020.06.01
Alternate Names:

D00HNB TTD Drug ID

Drug Info:

Publications:
DTC: CLODRONIC ACID
- Version: 02-September-2020
Alternate Names:

CHEMBL12318 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL12318
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	clodronate,Bonefos
Novel drug target	Established target

CLODRONIC ACID Drug Record

CLODRONIC ACID chembl:CHEMBL12318 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name clodronate,Bonefos Novel drug target Established target

PMIDs: 11961144 11752352

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name clodronate,Bonefos Novel drug target Established target

PMIDs: 11961144

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name clodronate,Bonefos Novel drug target Established target

PMIDs: 11961144

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12388372

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16424086

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14512092

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11984068

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16257277

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19020788 18443790 15739035 12608943 12162507 10692979

Sources: PharmGKB

TdgClinicalTrial: CLODRONATE

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: CLODRONATE

Alternate Names: C1418 NCI drug code

Drug Info:

PharmGKB: clodronate

Alternate Names:

Drug Info:

TTD: Clodronate

Alternate Names: D00HNB TTD Drug ID

Drug Info:

Publications:

DTC: CLODRONIC ACID

Alternate Names: CHEMBL12318 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL12318

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name clodronate,Bonefos

Novel drug target Established target

PMIDs:
11961144 11752352

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name clodronate,Bonefos

Novel drug target Established target

PMIDs:
11961144

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name clodronate,Bonefos

Novel drug target Established target

PMIDs:
11961144

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
12388372

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16424086

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14512092

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11984068

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16257277

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19020788 18443790 15739035 12608943 12162507 10692979

Sources:
PharmGKB

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C1418 NCI drug code

Alternate Names:

D00HNB TTD Drug ID

Alternate Names:

CHEMBL12318 ChEMBL Drug ID