DGIdb - CLOFIBRATE Drug Record

CLOFIBRATE chembl:CHEMBL565 Approved

Alternate Names:

NSC-79389
CLOFIBRATE
ICI-28257
AY-61123
ATROMID
ATROMID-S
CHLORFENISATE
2-(P-CHLOROPHENOXY)-2-METHYLPROPIONIC ACID ETHYL ESTER
ETHYL 2-(P-CHLOROPHENOXY)ISOBUTYRATE
ALPHA-(P-CHLOROPHENOXY)ISOBUTYRIC ACID, ETHYL ESTER
ATROMID-S®
EPIB
LIPOFACTON
ETHYL CHLOROPHENOXYISOBUTYRATE
CLOFIBRATUM
LIPRIN
ALPHA-P-CHLOROPHENOXYISOBUTYRYL ETHYL ESTER
CLOFIBRATO
ELPI
2-(4-CHLOROPHENOXY)-2-METHYLPROPANOIC ACID ETHYL ESTER
ETHYL CLOFIBRATE
chemidplus:637-07-0
drugbank:00636
rxcui:2594
pubchem.compound:2796
chembl:CHEMBL565

Drug Info:

FDA Approval	1967
Drug Class	small molecule
Drug Indications	Anticholesteremic Agents
Drug Class	anticholesteremic agents
Year of Approval	1967

(4 More Sources)

Publications:

Zhang X et al., 2000, Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells., Arch Biochem Biophys
Hsu MH et al., 2007, Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin., J Biol Chem
Parker RS et al., 2004, Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism., Ann N Y Acad Sci
Sontag TJ et al., 2002, Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status., J Biol Chem
Parker RS et al., 2000, Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin., Biochem Biophys Res Commun
Yamazaki et al., 2005, Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport., Xenobiotica
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
Casas et al., 2000, A 45 kDa protein related to PPARgamma2, induced by peroxisome proliferators, is located in the mitochondrial matrix., FEBS Lett.
Palkar et al., 2010, Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development., Toxicology
Kömüves et al., 2000, Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo., J. Invest. Dermatol.
Gelosa et al., 2010, Peroxisome proliferator-activated receptor {alpha} agonism prevents renal damage and the oxidative stress and inflammatory processes affecting the brains of stroke-prone rats., J. Pharmacol. Exp. Ther.
Murata et al., 2000, Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro., Biochem. Biophys. Res. Commun.
Barclay et al., 1999, Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent., J. Pharmacol. Exp. Ther.
Hunt et al., 2000, Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases., J. Lipid Res.
Lefevre et al., 2001, Effects of polyunsaturated fatty acids and clofibrate on chicken stearoyl-coA desaturase 1 gene expression., Biochem. Biophys. Res. Commun.
Brandes et al., 1990, Induction of fatty acid binding protein by peroxisome proliferators in primary hepatocyte cultures and its relationship to the induction of peroxisomal beta-oxidation., Biochim. Biophys. Acta
Long et al., 1996, Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2., J. Biol. Chem.

CLOFIBRATE CYP4F2

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10860554 17142457 15753130 11997390 11061988

Sources:
PharmGKB
CLOFIBRATE FABP1

Interaction Score: 2.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2328261

Sources:
NCI
CLOFIBRATE SCD

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11162472

Sources:
NCI
CLOFIBRATE CFL1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOFIBRATE PPARA

Interaction Score: 0.72

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist

PMIDs:
10922459 20637823 10951268 20671072 10753628 10454501 10787442

Sources:
TdgClinicalTrial ChemblInteractions TEND
CLOFIBRATE LPL

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CLOFIBRATE SLC2A4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8557642

Sources:
NCI
CLOFIBRATE JUN

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOFIBRATE CDK1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOFIBRATE SLCO1B1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16316932

Sources:
NCI
CLOFIBRATE TP53

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOFIBRATE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLOFIBRATE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLOFIBRATE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLOFIBRATE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: CLOFIBRATE
- Version: 01-August-2011
Alternate Names:

CLOFIBRATE Primary Drug Name

Drug Info:

Year of Approval 1967

Drug Class anticholesteremic agents

Publications:
TdgClinicalTrial: CLOFIBRATE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticholesteremic Agents

Drug Class small molecule

FDA Approval 1967

Publications:

NCI: CLOFIBRATE

Version: 14-September-2017

Alternate Names:

C378 NCI drug code

Drug Info:

Publications:

Lefevre et al., 2001, Effects of polyunsaturated fatty acids and clofibrate on chicken stearoyl-coA desaturase 1 gene expression., Biochem. Biophys. Res. Commun.

Brandes et al., 1990, Induction of fatty acid binding protein by peroxisome proliferators in primary hepatocyte cultures and its relationship to the induction of peroxisomal beta-oxidation., Biochim. Biophys. Acta

Long et al., 1996, Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2., J. Biol. Chem.

DTC: CLOFIBRATE

Version: 02-September-2020

Alternate Names:

CHEMBL565 ChEMBL Drug ID

Drug Info:

Publications:

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: clofibrate

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zhang X et al., 2000, Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells., Arch Biochem Biophys

Parker RS et al., 2004, Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism., Ann N Y Acad Sci

Parker RS et al., 2000, Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin., Biochem Biophys Res Commun

TTD: Clofibrate
- Version: 2020.06.01
Alternate Names:

D0J5DC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL565
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL565
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Peroxisome proliferator-activated receptor alpha agonist

CLOFIBRATE Drug Record

CLOFIBRATE chembl:CHEMBL565 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10860554 17142457 15753130 11997390 11061988

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2328261

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11162472

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist

PMIDs: 10922459 20637823 10951268 20671072 10753628 10454501 10787442

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8557642

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16316932

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: CLOFIBRATE

Alternate Names: CLOFIBRATE Primary Drug Name

Drug Info: Year of Approval 1967 Drug Class anticholesteremic agents

Publications:

TdgClinicalTrial: CLOFIBRATE

Alternate Names:

Drug Info: Drug Indications Anticholesteremic Agents Drug Class small molecule FDA Approval 1967

Publications:

NCI: CLOFIBRATE

Alternate Names: C378 NCI drug code

Drug Info:

DTC: CLOFIBRATE

Alternate Names: CHEMBL565 ChEMBL Drug ID

Drug Info:

Publications: MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

Interaction Types & Directionality:

n/a

PMIDs:
10860554 17142457 15753130 11997390 11061988

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2328261

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11162472

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor alpha agonist

PMIDs:
10922459 20637823 10951268 20671072 10753628 10454501 10787442

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8557642

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16316932

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

CLOFIBRATE Primary Drug Name

Drug Info:

Year of Approval 1967

Drug Class anticholesteremic agents

Drug Info:

Drug Indications Anticholesteremic Agents

Drug Class small molecule

FDA Approval 1967

Alternate Names:

C378 NCI drug code

Alternate Names:

CHEMBL565 ChEMBL Drug ID

Publications:

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0J5DC TTD Drug ID