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CLONIDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • CLONIDINE chembl:CHEMBL134 Approved

    Alternate Names:

    CLONIDINE
    COMBIPRES
    CLORPRES
    ST-155BS
    ST-155-BS
    DURACLON
    CATAPRES-TTS-2
    CATAPRES-TTS-3
    CATAPRES-TTS-1
    CATAPRES
    KAPVAY&REG
    CATAPRES®
    drugbank:00575
    chemidplus:4205-90-7
    chembl:CHEMBL134
    rxcui:2599
    pubchem.compound:2803

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications for treatment of diabetic neuropathy,for treatment of ADHD,antimucositic
    Year of Approval approved before 1982
    Drug Class antihypertensive agents
    (4 More Sources)

    Publications:

    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
    Lavand'homme et al., 2002, Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury., Anesthesiology
    Wang et al., 2002, Effect of antisense knock-down of alpha(2a)- and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat., Pain
    Ozdogan et al., 2004, The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice., Eur. J. Pharmacol.
    Fairbanks et al., 2002, alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy., J. Pharmacol. Exp. Ther.
    Ozdoğan et al., 2004, Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice., Eur. J. Pharmacol.
    Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
    Yang YY et al., 2010, Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial., Gut
    Pende et al., 1987, Interaction between morphine, an opioid agonist, and clonidine, an alpha-adrenergic agonist, on the regulation of anterior pituitary hormone secretion in normal male subjects., Biomed. Pharmacother.
    Nürnberger J et al., 2003, Effect of the C825T polymorphism of the G protein beta 3 subunit on the systolic blood pressure-lowering effect of clonidine in young, healthy male subjects., Clin Pharmacol Ther
  • CLONIDINE   AOC3

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CLONIDINE   GNB3

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20833658 12844135


    Sources:
    PharmGKB

  • CLONIDINE   ADRA2A

    Interaction Score: 1.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes
    Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

    PMIDs:
    16407989 12357167 12098614 15306201 11752127 14757140 11082457


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • CLONIDINE   ADRA2B

    Interaction Score: 0.56

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes
    Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

    PMIDs:
    11082457


    Sources:
    TdgClinicalTrial ChemblInteractions PharmGKB

  • CLONIDINE   ADRA2C

    Interaction Score: 0.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes
    Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

    PMIDs:
    20833658 11082457


    Sources:
    TdgClinicalTrial ChemblInteractions PharmGKB

  • CLONIDINE   PRL

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3663877


    Sources:
    NCI

  • CLONIDINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC PharmGKB

  • CLONIDINE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLONIDINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: CLONIDINE

    • Version: 01-August-2011

    Alternate Names:
    CLONIDINE Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: CLONIDINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of diabetic neuropathy,for treatment of ADHD,antimucositic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: CLONIDINE

    • Version: 14-September-2017

    Alternate Names:
    C380 NCI drug code

    Drug Info:

    Publications:
    Pende et al., 1987, Interaction between morphine, an opioid agonist, and clonidine, an alpha-adrenergic agonist, on the regulation of anterior pituitary hormone secretion in normal male subjects., Biomed. Pharmacother.

  • DTC: CLONIDINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL134 ChEMBL Drug ID

    Drug Info:

    Publications:
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

  • PharmGKB: clonidine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Yang YY et al., 2010, Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial., Gut
    Nürnberger J et al., 2003, Effect of the C825T polymorphism of the G protein beta 3 subunit on the systolic blood pressure-lowering effect of clonidine in young, healthy male subjects., Clin Pharmacol Ther

  • TTD: Clonidine

    • Version: 2020.06.01

    Alternate Names:
    D03SKR TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL134

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL134

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21