DGIdb - CLONIDINE Drug Record

CLONIDINE chembl:CHEMBL134 Approved

Alternate Names:

CLONIDINE
COMBIPRES
CLORPRES
ST-155BS
ST-155-BS
DURACLON
CATAPRES-TTS-2
CATAPRES-TTS-3
CATAPRES-TTS-1
CATAPRES
KAPVAY&REG
CATAPRES®
drugbank:00575
chemidplus:4205-90-7
chembl:CHEMBL134
rxcui:2599
pubchem.compound:2803

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of diabetic neuropathy,for treatment of ADHD,antimucositic
Year of Approval	approved before 1982
Drug Class	antihypertensive agents

(4 More Sources)

Publications:

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
Lavand'homme et al., 2002, Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury., Anesthesiology
Wang et al., 2002, Effect of antisense knock-down of alpha(2a)- and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat., Pain
Ozdogan et al., 2004, The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice., Eur. J. Pharmacol.
Fairbanks et al., 2002, alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy., J. Pharmacol. Exp. Ther.
Ozdoğan et al., 2004, Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice., Eur. J. Pharmacol.
Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
Yang YY et al., 2010, Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial., Gut
Pende et al., 1987, Interaction between morphine, an opioid agonist, and clonidine, an alpha-adrenergic agonist, on the regulation of anterior pituitary hormone secretion in normal male subjects., Biomed. Pharmacother.
Nürnberger J et al., 2003, Effect of the C825T polymorphism of the G protein beta 3 subunit on the systolic blood pressure-lowering effect of clonidine in young, healthy male subjects., Clin Pharmacol Ther

CLONIDINE AOC3

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CLONIDINE GNB3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20833658 12844135

Sources:
PharmGKB
CLONIDINE ADRA2A

Interaction Score: 1.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
16407989 12357167 12098614 15306201 11752127 14757140 11082457

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
CLONIDINE ADRA2B

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
11082457

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB
CLONIDINE ADRA2C

Interaction Score: 0.55

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
20833658 11082457

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB
CLONIDINE PRL

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3663877

Sources:
NCI
CLONIDINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC PharmGKB
CLONIDINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLONIDINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: CLONIDINE
- Version: 01-August-2011
Alternate Names:

CLONIDINE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: CLONIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of diabetic neuropathy,for treatment of ADHD,antimucositic

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: CLONIDINE

Version: 14-September-2017

Alternate Names:

C380 NCI drug code

Drug Info:

Publications:

Pende et al., 1987, Interaction between morphine, an opioid agonist, and clonidine, an alpha-adrenergic agonist, on the regulation of anterior pituitary hormone secretion in normal male subjects., Biomed. Pharmacother.

DTC: CLONIDINE
- Version: 02-September-2020
Alternate Names:

CHEMBL134 ChEMBL Drug ID

Drug Info:

Publications:

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

PharmGKB: clonidine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Yang YY et al., 2010, Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial., Gut

Nürnberger J et al., 2003, Effect of the C825T polymorphism of the G protein beta 3 subunit on the systolic blood pressure-lowering effect of clonidine in young, healthy male subjects., Clin Pharmacol Ther

TTD: Clonidine
- Version: 2020.06.01
Alternate Names:

D03SKR TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL134
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL134
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Adrenergic receptor alpha-2 agonist
Direct Interaction	yes
Trial Name	ARC-4558, 0.1% clonidine hycrochloride gel

CLONIDINE Drug Record

CLONIDINE chembl:CHEMBL134 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20833658 12844135

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs: 16407989 12357167 12098614 15306201 11752127 14757140 11082457

Sources: DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs: 11082457

Sources: TdgClinicalTrial ChemblInteractions PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs: 20833658 11082457

Sources: TdgClinicalTrial ChemblInteractions PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3663877

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: CLONIDINE

Alternate Names: CLONIDINE Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval approved before 1982

Publications:

TdgClinicalTrial: CLONIDINE

Alternate Names:

Drug Info: Drug Indications for treatment of diabetic neuropathy,for treatment of ADHD,antimucositic Drug Class Small Molecule FDA Approval approved

Publications:

NCI: CLONIDINE

Alternate Names: C380 NCI drug code

Drug Info:

Publications: Pende et al., 1987, Interaction between morphine, an opioid agonist, and clonidine, an alpha-adrenergic agonist, on the regulation of anterior pituitary hormone secretion in normal male subjects., Biomed. Pharmacother.

DTC: CLONIDINE

Alternate Names: CHEMBL134 ChEMBL Drug ID

Drug Info:

Publications: Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

PharmGKB: clonidine

Alternate Names:

Drug Info:

TTD: Clonidine

Alternate Names: D03SKR TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL134

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL134

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20833658 12844135

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
16407989 12357167 12098614 15306201 11752127 14757140 11082457

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
11082457

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
20833658 11082457

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
3663877

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CLONIDINE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval approved before 1982

Drug Info:

Drug Indications for treatment of diabetic neuropathy,for treatment of ADHD,antimucositic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C380 NCI drug code

Publications:

Pende et al., 1987, Interaction between morphine, an opioid agonist, and clonidine, an alpha-adrenergic agonist, on the regulation of anterior pituitary hormone secretion in normal male subjects., Biomed. Pharmacother.

Alternate Names:

CHEMBL134 ChEMBL Drug ID

Publications:

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

Alternate Names:

D03SKR TTD Drug ID