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COCAINE Drug Record

  • Summary
  • Interactions
  • Claims
  • COCAINE chembl:CHEMBL370805 Approved

    Alternate Names:

    RX-0041
    RX0041
    COCAINE
    IDS-NC-004
    BETA-COCAIN
    KOKAIN
    (-)-COCAINE
    METHYL [1R-(EXO,EXO)]-3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLATE
    COCAINUM
    L-COCAIN
    METHYL BENZOYLECGONINE
    BENZOYLMETHYLECGONINE
    2-METHYL-3BETA-HYDROXY-1ALPHAH,5ALPHAH-TROPANE-2BETA-CARBOXYLATE BENZOATE (ESTER)
    [1R-(EXO,EXO)]-3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, METHYL ESTER
    NEUROCAINE
    L-COCAINE
    COCAINA
    (−)-COCAINE
    COCAIN
    chembl:CHEMBL370805
    drugbank:00907
    rxcui:2653
    pubchem.compound:446220
    chemidplus:50-36-2

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications local anesthetic
    Year of Approval approved before 1982
    Drug Class anesthetics, local
    (1 More Sources)

    Publications:

    Patkar et al., 2002, Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals., Psychiatry Res
    Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
    Barker et al., 1999, Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter., J. Neurosci.
    Carrera et al., 2004, Cocaine pharmacology and current pharmacotherapies for its abuse., Bioorg. Med. Chem.
    Corey et al., 1994, A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization., Proc. Natl. Acad. Sci. U.S.A.
    Zhao et al., Perinatal cocaine exposure reduces myocardial norepinephrine transporter function in the neonatal rat., Neurotoxicol Teratol
    Burchett et al., 1997, Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to 'binge' cocaine administration., Brain Res. Mol. Brain Res.
    Galli et al., 1995, Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants., J. Exp. Biol.
    Antzelevitch, 2006, Brugada syndrome., Pacing Clin Electrophysiol
    Satish et al., 2005, Brugada syndrome--an update., Chang Gung Med J
    Wright et al., 1999, State-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit., Biophys. J.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Negrão AB et al., 2013, Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes., PLoS One
    Wilson et al., 1996, Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users., Ann. Neurol.
    Rothman et al., 1999, Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library., Synapse
    Kim et al., 2003, Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors., J. Med. Chem.
    Verma V, 2015, Classic Studies on the Interaction of Cocaine and the Dopamine Transporter., Clin Psychopharmacol Neurosci
    Türkan H et al., 2019, The association between the OPRM1 A118G polymorphism and addiction in a Turkish population., Arh Hig Rada Toksikol
    Arias A et al., 2006, Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis., Drug Alcohol Depend
    Schinka JA et al., 2002, A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances., Mol Psychiatry
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Aroche AP et al., 2020, Association of CHRNA5 Gene Variants with Crack Cocaine Addiction., Neuromolecular Med
    da Silva BS et al., 2019, The association between SYT1-rs2251214 and cocaine use disorder further supports its role in psychiatry., Prog Neuropsychopharmacol Biol Psychiatry
  • COCAINE   SYT1

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31059723


    Sources:
    PharmGKB

  • COCAINE   CHRNA5

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32152934


    Sources:
    PharmGKB

  • COCAINE   SLC6A1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • COCAINE   SLC6A3

    Interaction Score: 0.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8797532 10420171 15351386 12672245 9537821 26598579


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • COCAINE   SLC6A2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15113605 15351386 9387868 7500004


    Sources:
    TdgClinicalTrial TEND

  • COCAINE   SLC6A4

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12057823 9537821 10366604 15351386 8302852


    Sources:
    TdgClinicalTrial TEND

  • COCAINE   CHRNA3

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32152934


    Sources:
    PharmGKB

  • COCAINE   BCHE

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24312228


    Sources:
    PharmGKB

  • COCAINE   KAT2B

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • COCAINE   SCN5A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17038146 15880981 9876137


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • COCAINE   SCN11A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • COCAINE   SCN10A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • COCAINE   OPRM1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31246565 16387451 11840318


    Sources:
    PharmGKB

  • COCAINE   CNR1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • COCAINE   DRD3

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • COCAINE   OPRK1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • COCAINE   OPRD1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • COCAINE   GABRA2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • COCAINE   DRD1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • COCAINE   DRD2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • COCAINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • TdgClinicalTrial: COCAINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications local anesthetic
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • TEND: COCAINE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class anesthetics, local
    Year of Approval approved before 1982

    Publications:

  • PharmGKB: cocaine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Aroche AP et al., 2020, Association of CHRNA5 Gene Variants with Crack Cocaine Addiction., Neuromolecular Med
    Negrão AB et al., 2013, Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes., PLoS One
    Schinka JA et al., 2002, A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances., Mol Psychiatry

  • TTD: Cocaine

    • Version: 2020.06.01

    Alternate Names:
    D04XPW TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL370805

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21