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COMBRETASTATIN A4 Drug Record

  • Summary
  • Interactions
  • Claims
  • COMBRETASTATIN A4 chembl:CHEMBL67

    Alternate Names:

    COMBRESTATIN A4
    NSC-613729

    Drug Info:

    (0 More Sources)

    Publications:

    Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
    Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
    Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
    Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
    Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
    Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
    Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
  • COMBRETASTATIN A4   TUBB4A

    Interaction Score: 1.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBA3C

    Interaction Score: 1.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBA3D

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 16913727 22543234 25584687 24669888 17765552 25192811


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBB8

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBA3E

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBB6

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBA4A

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBA1C

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBA1B

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBB2B

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBB3

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBB2A

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBA1A

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBB4B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBB

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   TUBB1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COMBRETASTATIN A4   MAPK3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • COMBRETASTATIN A4   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • DTC: COMBRETASTATIN A4

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL67 ChEMBL Drug ID

    Drug Info:

    Publications:
    Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
    Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
    Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem

  • ChemblDrugs: chembl:CHEMBL67

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21