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COPPER Drug Record

  • Summary
  • Interactions
  • Claims
  • COPPER chembl:CHEMBL55643 Approved

    Alternate Names:

    COPPER
    TATUM-T
    PARAGARD T 380A
    CU-7

    Drug Info:

    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational
    Drug Categories copper-containing intrauterine device
    Drug Categories decreased embryonic implantation
    Drug Categories decreased sperm motility
    Drug Categories diet, food, and nutrition
    Drug Categories elements
    Drug Categories food
    Drug Categories food and beverages
    Drug Categories growth substances
    Drug Categories inhibit ovum fertilization
    Drug Categories metals
    Drug Categories metals, heavy
    Drug Categories micronutrients
    Drug Categories minerals
    Drug Categories physiological phenomena
    Drug Categories replacement preparations
    Drug Categories trace elements
    Drug Categories transition elements
    (0 More Sources)

    Publications:

    Wang F et al., 2013, Immobilized metal affinity chromatography and human serum proteomics., J Chromatogr B Analyt Technol Biomed Life Sci
    Hegde ML et al., 2010, Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases., J Biol Chem
    Smith SD et al., 2004, Using immobilized metal affinity chromatography, two-dimensional electrophoresis and mass spectrometry to identify hepatocellular proteins with copper-binding ability., J Proteome Res
    Rose F et al., 2011, Mechanism of copper(II)-induced misfolding of Parkinson's disease protein., Sci Rep
    She YM et al., 2003, Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry., Mol Cell Proteomics
    Chen Z et al., 2006, Identification of residues critical for Cu2+-mediated inhibition of glycine alpha1 receptors., Neuropharmacology
    Lee EC et al., 2013, Copper(II)-human amylin complex protects pancreatic cells from amylin toxicity., Phys Chem Chem Phys
    Banci L et al., 2006, A hint for the function of human Sco1 from different structures., Proc Natl Acad Sci U S A
    Haase-Kohn C et al., 2011, Copper-mediated cross-linking of S100A4, but not of S100A2, results in proinflammatory effects in melanoma cells., Biochem Biophys Res Commun
    Mayer MC et al., 2014, Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization., J Biol Chem
    Winterbourn CC et al., 1977, Oxidation of human haemoglobin by copper. Mechanism and suggested role of the thiol group of residue beta-93., Biochem J
    Thompson LC et al., 2011, Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes., Protein Sci
    Lind SE et al., 1993, Oxidative inactivation of plasmin and other serine proteases by copper and ascorbate., Blood
    Björkblom B et al., 2013, Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity., J Biol Chem
    Petrak J et al., 2005, Hephaestin--a ferroxidase of cellular iron export., Int J Biochem Cell Biol
    Tapiero H et al., 2003, Trace elements in human physiology and pathology. Copper., Biomed Pharmacother
    White AR et al., 2002, Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein., J Neurosci
    Suzuki K et al., 2001, Inhibitory effect of copper(II) on zinc(II)-induced aggregation of amyloid beta-peptide., Biochem Biophys Res Commun
    Luo LZ et al., 2011, Different binding affinities of Pb2+ and Cu2+ to glycosylation variants of human serum transferrin interfere with the detection of carbohydrate-deficient transferrin., Biol Trace Elem Res
    Fox JH et al., 2007, Mechanisms of copper ion mediated Huntington's disease progression., PLoS One
    Travaglia A et al., 2012, Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives., Chemistry
    Li Y et al., 2004, Binding of Cu2+ to S-adenosyl-L-homocysteine hydrolase., J Inorg Biochem
    Deng NJ et al., 2006, Molecular basis for the Cu2+ binding-induced destabilization of beta2-microglobulin revealed by molecular dynamics simulation., Biophys J
    Muranjan M et al., 1998, Characterization of the human serum trypanosome toxin, haptoglobin-related protein., J Biol Chem
    Baker BL et al., 1978, A copper-binding immunoglobulin from a myeloma patient. Purification, identification, and physical characterization., J Biol Chem
    Remelli M et al., 2012, Thermodynamic and spectroscopic investigation on the role of Met residues in Cu(II) binding to the non-octarepeat site of the human prion protein., Metallomics
    Shearer J et al., 2007, The copper(II) adduct of the unstructured region of the amyloidogenic fragment derived from the human prion protein is redox-active at physiological pH., Inorg Chem
    Pushie MJ et al., 2009, A potential mechanism for Cu2+ reduction, beta-cleavage, and beta-sheet initiation within the N-terminal domain of the prion protein: insights from density functional theory and molecular dynamics calculations., J Toxicol Environ Health A
    Valensin G et al., 2009, Molecular dynamics study of the Cu2+ binding-induced "structuring" of the N-terminal domain of human prion protein., J Phys Chem B
    Shiraishi N et al., 2006, Combination of NADPH and copper ions generates proteinase K-resistant aggregates from recombinant prion protein., J Biol Chem
    Wells MA et al., 2006, A reassessment of copper(II) binding in the full-length prion protein., Biochem J
    Merle U et al., 2006, Influence of homozygosity for methionine at codon 129 of the human prion gene on the onset of neurological and hepatic symptoms in Wilson disease., Arch Neurol
    Russino D et al., 2013, The tachykinin peptide neurokinin B binds copper forming an unusual [CuII(NKB)2] complex and inhibits copper uptake into 1321N1 astrocytoma cells., ACS Chem Neurosci
    Bryan SE et al., 1976, Interactions of mercury and copper with constitutive heterochromatin and euchromatin in vivo and in vitro., Biochemistry
    Xu H et al., 2014, Interactions of metals and Apolipoprotein E in Alzheimer's disease., Front Aging Neurosci
  • COPPER   HSPA13

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   PRNP

    Interaction Score: 1.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22791135 17257012 19697239 19236027 16990274 16824036 16831968


    Sources:
    DrugBank

  • COPPER   LUM

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   TKT

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   HIST1H2BC

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351


    Sources:
    DrugBank

  • COPPER   CBX5

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1268189


    Sources:
    DrugBank

  • COPPER   RPS2

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   RACK1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   HIST1H1E

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351


    Sources:
    DrugBank

  • COPPER   IGLL1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    203585


    Sources:
    DrugBank

  • COPPER   C9

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   APOC2

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   STIP1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   HNRNPH1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   SERPINA7

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   HDGF

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   ACTN1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   ANXA4

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   APOD

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   SRSF1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   HEPHL1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:

    PMIDs:
    15778082


    Sources:
    DrugBank

  • COPPER   PARK7

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23792957


    Sources:
    DrugBank

  • COPPER   LRG1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   HNRNPL

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   APOH

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   HNRNPH3

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   SERPINF1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   PPBP

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   AFM

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   SF3A2

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   EIF6

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   SCO1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16735468


    Sources:
    DrugBank

  • COPPER   IGHG4

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   ACTG1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   AHCY

    Interaction Score: 0.39

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:

    PMIDs:
    14652164 15149804


    Sources:
    DrugBank

  • COPPER   PDIA3

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   C8B

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   TAC3

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23875773


    Sources:
    DrugBank

  • COPPER   APOA2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   HPR

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9461571


    Sources:
    DrugBank

  • COPPER   PRDX6

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   APOA4

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   SERPINF2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   CLIC1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   HNRNPA2B1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   AZGP1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   YWHAB

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   CFI

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   KRT1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   PGAM1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   IGKV3-20

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   UGDH

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   SERPINA4

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   SFPQ

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   APOC3

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   KRT10

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   C1QBP

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   A1BG

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   IAPP

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23793354


    Sources:
    DrugBank

  • COPPER   RANBP1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   PRDX2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   HSPD1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   ENO1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   PRDX1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   AHSG

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   KRT8

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351


    Sources:
    DrugBank

  • COPPER   PSME1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   ACY1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   APOBR

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   IGFALS

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   GSN

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   KRT9

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   ITIH2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   NEIL2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20622253


    Sources:
    DrugBank

  • COPPER   C4B

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   PEBP1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   PGLYRP2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   KRT2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   APLP1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:

    PMIDs:
    24855651


    Sources:
    DrugBank

  • COPPER   CLEC3B

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   C4BPA

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   EIF4A1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   NEIL1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20622253


    Sources:
    DrugBank

  • COPPER   RPSA

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   AKR1A1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   VTN

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   APCS

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   IDH3A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   SERPING1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   KNG1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   ANXA5

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   C1S

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   B2M

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16513784


    Sources:
    DrugBank

  • COPPER   PGK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   S100A8

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351


    Sources:
    DrugBank

  • COPPER   SERPIND1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   S100A2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21924240


    Sources:
    DrugBank

  • COPPER   S100A4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21924240


    Sources:
    DrugBank

  • COPPER   GSS

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   TF

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21792595 14534351 15359738


    Sources:
    DrugBank

  • COPPER   CLU

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   PTGES3

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   CFH

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   EEF1A1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351


    Sources:
    DrugBank

  • COPPER   IGHG1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   SERPINA1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   C3

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   GOT1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   C1QC

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   GPI

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   PPIA

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   LDHA

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   HSP90B1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351


    Sources:
    DrugBank

  • COPPER   SERPINA6

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   CALR

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   P4HB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   NME1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   C5

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   PON1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   CYB5R3

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   CFL1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   APOA1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   HSPA5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   TTR

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   GAPDH

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14534351 15359738


    Sources:
    DrugBank

  • COPPER   HBA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   AGT

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   HSPA8

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   APOE

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24971061


    Sources:
    DrugBank

  • COPPER   APP

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    14652164 11784781 11467850


    Sources:
    DrugBank

  • COPPER   GSR

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   TUBA3C

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   SERPINE1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21280128


    Sources:
    DrugBank

  • COPPER   SERPINC1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   PLG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8364203


    Sources:
    DrugBank

  • COPPER   GLRA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16842826


    Sources:
    DrugBank

  • COPPER   SNCA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22355530


    Sources:
    DrugBank

  • COPPER   HBB

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    889569


    Sources:
    DrugBank

  • COPPER   PKM

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   TUBB

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   BDNF

    Interaction Score: 0.01

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:

    PMIDs:
    23135810


    Sources:
    DrugBank

  • COPPER   F2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • COPPER   HSP90AA1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15359738


    Sources:
    DrugBank

  • COPPER   HTT

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17396163


    Sources:
    DrugBank

  • DrugBank: DB09130

    • Version: 5.1.7

    Alternate Names:
    COPPER DrugBank Drug Name
    7440-50-8 CAS Number
    24 Multivitamins + Minerals Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Tapiero H et al., 2003, Trace elements in human physiology and pathology. Copper., Biomed Pharmacother
    White AR et al., 2002, Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein., J Neurosci
    Suzuki K et al., 2001, Inhibitory effect of copper(II) on zinc(II)-induced aggregation of amyloid beta-peptide., Biochem Biophys Res Commun

  • ChemblDrugs: chembl:CHEMBL55643

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21