DGIdb - CUDC-101 Drug Record

CUDC-101 chembl:CHEMBL598797 Antineoplastic

Alternate Names:

CUDC-101
CUDC 101

Drug Info:

FDA Approval	not approved
Drug Indications	antineoplastic agent
Drug Class	Small molecule

(4 More Sources)

Publications:

Shimizu et al., 2014, Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumors., Clin. Cancer Res.
Lai et al., 2010, CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity., Cancer Res.

CUDC-101 HDAC10

Interaction Score: 0.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CUDC-101 HDAC7

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CUDC-101 HDAC5

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CUDC-101 HDAC4

Interaction Score: 0.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CUDC-101 HDAC8

Interaction Score: 0.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CUDC-101 HDAC3

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction? False

Endogenous Drug? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CUDC-101 HDAC2

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CUDC-101 HDAC6

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CUDC-101 HDAC9

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial GuideToPharmacology
CUDC-101 HDAC1

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name CUDC-101

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology
CUDC-101 HDAC11

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CUDC-101 ERBB2

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
25107918

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions GuideToPharmacology TTD
CUDC-101 EGFR

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
20388807

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions GuideToPharmacology TTD
CUDC-101 YES1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: CUDC-101
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class Small molecule

Drug Indications antineoplastic agent

FDA Approval not approved

Publications:

JAX-CKB: CUDC-101

Version: 27-September-2017

Alternate Names:

Drug Info:

Publications:

Lai et al., 2010, CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity., Cancer Res.

Shimizu et al., 2014, Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumors., Clin. Cancer Res.

TALC: CUDC-101
- Version: 12-May-2016
Alternate Names:

CUDC-101 Drug Synonym

CUDC-101 Primary Drug Name

Drug Info:

Publications:
GuideToPharmacology: 310264675
- Version: 29-September-2020
Alternate Names:

CUDC-101 GuideToPharmacology Ligand Name

Drug Info:

Publications:
DTC: CUDC-101
- Version: 02-September-2020
Alternate Names:

CHEMBL598797 ChEMBL Drug ID

Drug Info:

Publications:
TTD: CUDC-101
- Version: 2020.06.01
Alternate Names:

D0Z4RC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL598797
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL598797
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	CUDC-101
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Mechanism of Interaction	Histone deacetylase inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

Notes
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Evidence Type	Actionable
Approval Status	Preclinical
Response Type	sensitive

CUDC-101 Drug Record

CUDC-101 chembl:CHEMBL598797 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Notes

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name CUDC-101 Novel drug target Established target

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction? False Endogenous Drug? False

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: TALC TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name CUDC-101 Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 25107918

Sources: TALC TdgClinicalTrial JAX-CKB ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Evidence Type Actionable Approval Status Preclinical Response Type sensitive

PMIDs: 20388807

Sources: TALC TdgClinicalTrial JAX-CKB ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TdgClinicalTrial: CUDC-101

Alternate Names:

Drug Info: Drug Class Small molecule Drug Indications antineoplastic agent FDA Approval not approved

Publications:

JAX-CKB: CUDC-101

Alternate Names:

Drug Info:

TALC: CUDC-101

Alternate Names: CUDC-101 Drug Synonym CUDC-101 Primary Drug Name

Drug Info:

Publications:

GuideToPharmacology: 310264675

Alternate Names: CUDC-101 GuideToPharmacology Ligand Name

Drug Info:

Publications:

DTC: CUDC-101

Alternate Names: CHEMBL598797 ChEMBL Drug ID

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction? False

Endogenous Drug? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TALC TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name CUDC-101

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
25107918

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
20388807

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Class Small molecule

Drug Indications antineoplastic agent

FDA Approval not approved

Alternate Names:

CUDC-101 Drug Synonym

CUDC-101 Primary Drug Name

Alternate Names:

CUDC-101 GuideToPharmacology Ligand Name

Alternate Names:

CHEMBL598797 ChEMBL Drug ID

Alternate Names:

D0Z4RC TTD Drug ID