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CUDC-101 Drug Record

  • Summary
  • Interactions
  • Claims
  • CUDC-101 chembl:CHEMBL598797 Antineoplastic

    Alternate Names:

    CUDC-101
    CUDC 101

    Drug Info:

    FDA Approval not approved
    Drug Indications antineoplastic agent
    Drug Class Small molecule
    (3 More Sources)

    Publications:

    Shimizu et al., 2014, Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumors., Clin. Cancer Res.
    Lai et al., 2010, CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity., Cancer Res.
  • CUDC-101   HDAC10

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CUDC-101
    Novel drug target Established target
    Notes

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC5

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CUDC-101
    Novel drug target Established target
    Notes

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC7

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC8

    Interaction Score: 0.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CUDC-101
    Novel drug target Established target
    Notes

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC3

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Novel drug target Established target
    Trial Name CUDC-101

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes
    Trial Name CUDC-101

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC6

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CUDC-101
    Novel drug target Established target
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC4

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name CUDC-101
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC11

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CUDC-101
    Novel drug target Established target
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name CUDC-101
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • CUDC-101   HDAC9

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name CUDC-101
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial

  • CUDC-101   ERBB2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CUDC-101
    Novel drug target Established target
    Notes

    PMIDs:
    25107918


    Sources:
    TALC TdgClinicalTrial JAX-CKB ChemblInteractions TTD

  • CUDC-101   EGFR

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical
    Response Type sensitive

    PMIDs:
    20388807


    Sources:
    TALC TdgClinicalTrial JAX-CKB ChemblInteractions TTD

  • CUDC-101   YES1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TdgClinicalTrial: CUDC-101

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    FDA Approval not approved

    Publications:

  • JAX-CKB: CUDC-101

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Lai et al., 2010, CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity., Cancer Res.
    Shimizu et al., 2014, Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumors., Clin. Cancer Res.

  • TALC: CUDC-101

    • Version: 12-May-2016

    Alternate Names:
    CUDC-101 Primary Drug Name
    CUDC-101 Drug Synonym

    Drug Info:

    Publications:

  • DTC: CUDC-101

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL598797 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: CUDC-101

    • Version: 2020.06.01

    Alternate Names:
    D0Z4RC TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL598797

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL598797

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21