DGIdb - CUDC-101 Drug Record

CUDC-101 chembl:CHEMBL598797 Antineoplastic

Alternate Names:

CUDC-101
CUDC 101

Drug Info:

FDA Approval	not approved
Drug Indications	antineoplastic agent
Drug Class	Small molecule

(3 More Sources)

Publications:

Shimizu et al., 2014, Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumors., Clin. Cancer Res.
Lai et al., 2010, CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity., Cancer Res.

CUDC-101 HDAC10

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC5

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC7

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC8

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC3

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name CUDC-101

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC2

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Trial Name CUDC-101

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC6

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC4

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC11

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC1

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name CUDC-101

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
CUDC-101 HDAC9

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
CUDC-101 ERBB2

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
25107918

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions TTD
CUDC-101 EGFR

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
20388807

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions TTD
CUDC-101 YES1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: CUDC-101
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class Small molecule

Drug Indications antineoplastic agent

FDA Approval not approved

Publications:

JAX-CKB: CUDC-101

Version: 27-September-2017

Alternate Names:

Drug Info:

Publications:

Lai et al., 2010, CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity., Cancer Res.

Shimizu et al., 2014, Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumors., Clin. Cancer Res.

TALC: CUDC-101
- Version: 12-May-2016
Alternate Names:

CUDC-101 Primary Drug Name

CUDC-101 Drug Synonym

Drug Info:

Publications:
DTC: CUDC-101
- Version: 02-September-2020
Alternate Names:

CHEMBL598797 ChEMBL Drug ID

Drug Info:

Publications:
TTD: CUDC-101
- Version: 2020.06.01
Alternate Names:

D0Z4RC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL598797
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL598797
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Notes
Direct Interaction	yes
Mechanism of Interaction	Histone deacetylase inhibitor

Trial Name	CUDC-101
Novel drug target	Established target
Mechanism of Interaction	Histone deacetylase inhibitor

Evidence Type	Actionable
Approval Status	Preclinical
Response Type	sensitive

CUDC-101 Drug Record

CUDC-101 chembl:CHEMBL598797 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Notes

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Notes

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction yes Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Notes

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Novel drug target Established target Trial Name CUDC-101

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes Trial Name CUDC-101

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name CUDC-101 Novel drug target Established target

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name CUDC-101 Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name CUDC-101 Novel drug target Established target

PMIDs: None found

Sources: TALC TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Notes

PMIDs: 25107918

Sources: TALC TdgClinicalTrial JAX-CKB ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Evidence Type Actionable Approval Status Preclinical Response Type sensitive

PMIDs: 20388807

Sources: TALC TdgClinicalTrial JAX-CKB ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TdgClinicalTrial: CUDC-101

Alternate Names:

Drug Info: Drug Class Small molecule Drug Indications antineoplastic agent FDA Approval not approved

Publications:

JAX-CKB: CUDC-101

Alternate Names:

Drug Info:

TALC: CUDC-101

Alternate Names: CUDC-101 Primary Drug Name CUDC-101 Drug Synonym

Drug Info:

Publications:

DTC: CUDC-101

Alternate Names: CHEMBL598797 ChEMBL Drug ID

Drug Info:

Publications:

TTD: CUDC-101

Alternate Names: D0Z4RC TTD Drug ID

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name CUDC-101

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Trial Name CUDC-101

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name CUDC-101

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name CUDC-101

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
25107918

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
20388807

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Class Small molecule

Drug Indications antineoplastic agent

FDA Approval not approved

Alternate Names:

CUDC-101 Primary Drug Name

CUDC-101 Drug Synonym

Alternate Names:

CHEMBL598797 ChEMBL Drug ID

Alternate Names:

D0Z4RC TTD Drug ID