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CYCLOBENZAPRINE Drug Record

  • Summary
  • Interactions
  • Claims
  • CYCLOBENZAPRINE chembl:CHEMBL669 Approved

    Alternate Names:

    CYCLOBENZAPRINE
    MK-130 (AS THE BASE)
    TNX-102
    FLEXERIL
    CICLOBENZAPRINA
    N,N-DIMETHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-DELTA(5,GAMMA)-PROPYLAMINE
    N,N-DIMETHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-Δ5,Γ-PROPYLAMINE
    FEXMID
    MK-130
    (3-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDENE-PROPYL)-DIMETHYL-AMINE
    CYCLOBENZAPRINUM
    AMRIX®
    chembl:CHEMBL669
    rxcui:21949
    pubchem.compound:2895
    drugbank:00924
    chemidplus:303-53-7

    Drug Info:

    FDA Approval 1977
    Drug Class small molecule
    Drug Indications Antidepressive Agents, Tricyclic
    Drug Class antidepressive agents, tricyclic
    Year of Approval 1977
    (3 More Sources)

    Publications:

    Kobayashi et al., 1996, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems., Eur. J. Pharmacol.
    Honda et al., 2003, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors., Eur. J. Pharmacol.
    Mestres J et al., 2011, Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome., Clin Pharmacol Ther
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
  • CYCLOBENZAPRINE   HTR2A

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8884233 12498911 21975349


    Sources:
    TdgClinicalTrial TEND TTD

  • CYCLOBENZAPRINE   CYP3A5

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • CYCLOBENZAPRINE   ADRA2C

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CYCLOBENZAPRINE   DRD1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYCLOBENZAPRINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: CYCLOBENZAPRINE

    • Version: 01-August-2011

    Alternate Names:
    CYCLOBENZAPRINE Primary Drug Name

    Drug Info:
    Year of Approval 1977
    Drug Class antidepressive agents, tricyclic

    Publications:

  • TdgClinicalTrial: CYCLOBENZAPRINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antidepressive Agents, Tricyclic
    Drug Class small molecule
    FDA Approval 1977

    Publications:

  • PharmGKB: cyclobenzaprine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

  • DTC: CYCLOBENZAPRINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL669 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Cyclobenzaprine

    • Version: 2020.06.01

    Alternate Names:
    D01KHH TTD Drug ID

    Drug Info:

    Publications:

  • TTD: TNX-102

    • Version: 2020.06.01

    Alternate Names:
    D0NN8N TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL669

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21