DGIdb - DANAZOL Drug Record

DANAZOL chembl:CHEMBL1479 ApprovedAntineoplastic

Alternate Names:

DANOCRINE
DANAZOL
NSC-270916
WIN-17757
DANAZOLUM
CYCLOMEN
DANOCRINE®
drugbank:01406
rxcui:3102
chembl:CHEMBL1479
pubchem.compound:28417
chemidplus:17230-88-5

Drug Info:

FDA Approval	1976
Drug Class	small molecule
Drug Indications	Antiendometriosis Agent, Antineoplastic Agent
Drug Class	antiendometriosis agent
Year of Approval	1976
Drug Class	antineoplastic agent

(4 More Sources)

Publications:

Gomez et al., 2000, Effects of androgen treatment on expression of macrophage Fcgamma receptors., Clin. Diagn. Lab. Immunol.
Roselli, 1998, The effect of anabolic-androgenic steroids on aromatase activity and androgen receptor binding in the rat preoptic area., Brain Res.
Donaldson, 1989, Danazol., Am. J. Med.
Sasagawa et al., 2008, Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile., Steroids
Dmowski, 1990, Danazol. A synthetic steroid with diverse biologic effects., J Reprod Med
Shepherd, 1995, Danazol and plasma lipoprotein metabolism., Int J Gynaecol Obstet
Bower et al., Failure of the synthetic androgen, danazol, to increase protein S levels and prevent thrombosis in a patient with severe protein S deficiency., Haemostasis
Cugno et al., 1988, Haemostasis contact system and fibrinolysis in hereditary angioedema (C1-inhibitor deficiency)., J. Clin. Chem. Clin. Biochem.
Beaumont et al., 2002, Danazol for heavy menstrual bleeding., Cochrane Database Syst Rev
Sanfilippo et al., 1985, Evaluation of danazol influence upon the uterus using scanning electron microscopic morphometric and biochemical analyses., Surg Gynecol Obstet
Snyder et al., 1990, Danazol suppression of luteinizing hormone in the rat: evidence for mediation by both androgen and estrogen receptors., Proc. Soc. Exp. Biol. Med.
Fujimoto et al., 1995, Danazol decreases transcription of estrogen receptor gene in human monocytes., Gen. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Menon et al., 1986, Inhibition of gonadotropin-releasing hormone receptors in rat anterior pituitary monolayer cell cultures by danazol., Am. J. Obstet. Gynecol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Tang et al., 2005, [Effects of xianggui pill on cytokine in endometriosis model rat]., Zhongguo Zhong Yao Za Zhi
Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
Tian et al., 2003, [Effect of Chinese herbal medicine for nourishing yin and purging fire on mRNA expressions of gonadotropin-releasing hormone and its receptor in precocious puberty model rats]., Zhongguo Zhong Xi Yi Jie He Za Zhi
Roth et al., 2004, Pituitary and gonadal effects of GnRH (gonadotropin releasing hormone) analogues in two peripubertal female rat models., Pediatr. Res.
Laurell et al., 1979, A comparison of plasma protein changes induced by danazol, pregnancy, and estrogens., J. Clin. Endocrinol. Metab.
Huang et al., 1994, [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells]., Zhongguo Zhong Xi Yi Jie He Za Zhi
Beaumont et al., 2007, Danazol for heavy menstrual bleeding., Cochrane Database Syst Rev
Prost-Avallet et al., 1991, In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma., J. Steroid Biochem. Mol. Biol.
Menon et al., 1980, Evidence that danazol inhibits gonadotropin-induced ovarian steroidogenesis at a point distal to gonadotropin-receptor interaction and adenosine 3',5' cyclic monophosphate formation., Am. J. Obstet. Gynecol.

DANAZOL MBL2

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12076401

Sources:
NCI
DANAZOL GNRHR2

Interaction Score: 2.9

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
3004220 17016423 17139284 2404115

Sources:
TdgClinicalTrial TEND
DANAZOL CGB5

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6243863

Sources:
NCI
DANAZOL STS

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1751397

Sources:
NCI
DANAZOL GNRHR

Interaction Score: 0.77

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14571621 3004220 14605254 2404115

Sources:
TdgClinicalTrial TEND
DANAZOL CYP2J2

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19923256

Sources:
PharmGKB
DANAZOL CP

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
489712

Sources:
NCI
DANAZOL PLG

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8529771 7607583 3146615

Sources:
NCI
DANAZOL PGR

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

PMIDs:
8000225 17636649 18061638 2404115

Sources:
ChemblInteractions
DANAZOL ESR1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
4039467 2326286 7540578 11752352

Sources:
DTC TdgClinicalTrial TEND TTD
DANAZOL CXCL8

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16161451

Sources:
NCI
DANAZOL AR

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Androgen Receptor agonist

PMIDs:
10882672 9593936 2486535 18061638 2404115

Sources:
DTC ChemblInteractions
DANAZOL CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DANAZOL CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DANAZOL CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DANAZOL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: DANAZOL
- Version: 01-August-2011
Alternate Names:

DANAZOL Primary Drug Name

Drug Info:

Drug Class antineoplastic agent

Year of Approval 1976

Drug Class antiendometriosis agent

Publications:
TdgClinicalTrial: DANAZOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antiendometriosis Agent, Antineoplastic Agent

Drug Class small molecule

FDA Approval 1976

Publications:

NCI: DANAZOL

Version: 14-September-2017

Alternate Names:

C414 NCI drug code

Drug Info:

Publications:

Tang et al., 2005, [Effects of xianggui pill on cytokine in endometriosis model rat]., Zhongguo Zhong Yao Za Zhi

Menon et al., 1980, Evidence that danazol inhibits gonadotropin-induced ovarian steroidogenesis at a point distal to gonadotropin-receptor interaction and adenosine 3',5' cyclic monophosphate formation., Am. J. Obstet. Gynecol.

Shepherd, 1995, Danazol and plasma lipoprotein metabolism., Int J Gynaecol Obstet

DTC: DANAZOL
- Version: 02-September-2020
Alternate Names:

CHEMBL1479 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
PharmGKB: danazol
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
TTD: Danazol
- Version: 2020.06.01
Alternate Names:

D09IPV TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1479
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1479
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Progesterone receptor agonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Androgen Receptor agonist

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

DANAZOL Drug Record

DANAZOL chembl:CHEMBL1479 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12076401

Sources: NCI

Interaction Types & Directionality: negative modulator (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 3004220 17016423 17139284 2404115

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6243863

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1751397

Sources: NCI

Interaction Types & Directionality: negative modulator (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 14571621 3004220 14605254 2404115

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19923256

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 489712

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8529771 7607583 3146615

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Progesterone receptor agonist Direct Interaction yes

PMIDs: 8000225 17636649 18061638 2404115

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 4039467 2326286 7540578 11752352

Sources: DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16161451

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Androgen Receptor agonist

PMIDs: 10882672 9593936 2486535 18061638 2404115

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: DANAZOL

Alternate Names: DANAZOL Primary Drug Name

Drug Info: Drug Class antineoplastic agent Year of Approval 1976 Drug Class antiendometriosis agent

Publications:

TdgClinicalTrial: DANAZOL

Alternate Names:

Drug Info: Drug Indications Antiendometriosis Agent, Antineoplastic Agent Drug Class small molecule FDA Approval 1976

Publications:

NCI: DANAZOL

Alternate Names: C414 NCI drug code

Drug Info:

Interaction Types & Directionality:

n/a

PMIDs:
12076401

Sources:
NCI

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
3004220 17016423 17139284 2404115

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
6243863

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1751397

Sources:
NCI

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14571621 3004220 14605254 2404115

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
19923256

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
489712

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8529771 7607583 3146615

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

PMIDs:
8000225 17636649 18061638 2404115

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
4039467 2326286 7540578 11752352

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
16161451

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Androgen Receptor agonist

PMIDs:
10882672 9593936 2486535 18061638 2404115

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

DANAZOL Primary Drug Name

Drug Info:

Drug Class antineoplastic agent

Year of Approval 1976

Drug Class antiendometriosis agent

Drug Info:

Drug Indications Antiendometriosis Agent, Antineoplastic Agent

Drug Class small molecule

FDA Approval 1976

Alternate Names:

C414 NCI drug code

Alternate Names:

CHEMBL1479 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Publications:

Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos

Alternate Names:

D09IPV TTD Drug ID