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DENILEUKIN DIFTITOX Drug Record

  • Summary
  • Interactions
  • Claims
  • DENILEUKIN DIFTITOX chembl:CHEMBL1201550 ApprovedAntineoplastic

    Alternate Names:

    DAB389IL2
    DAB-389IL2
    E7777
    DAB(SUB 389)IL2
    LY-335348
    DENILEUKIN DIFTITOX
    DAB389 IL2
    ONTAK
    E7272
    LY335348
    chemidplus:173146-27-5
    DT
    DIPHTHERIA TOXIN PRECURSOR
    NAD(+--DIPHTHAMIDE ADP- RIBOSYLTRANSFERASE)
    drugbank:00004
    chembl:CHEMBL1201550

    Drug Info:

    (0 More Sources)

    Publications:

    Foss et al., 2005, A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma., Blood
    Foss, 2006, Clinical experience with denileukin diftitox (ONTAK)., Semin. Oncol.
    Foss, 2000, DAB(389)IL-2 (denileukin diftitox, ONTAK): a new fusion protein technology., Clin Lymphoma
    Duvic et al., 2008, Optimizing denileukin diftitox (Ontak) therapy., Future Oncol
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Turturro, 2007, Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders., Expert Rev Anticancer Ther
    Kiyokawa et al., 1989, Cytotoxicity of interleukin 2-toxin toward lymphocytes from patients with adult T-cell leukemia., Cancer Res.
    Murphy et al., 1988, Interleukin 2 toxin: a step toward selective immunomodulation., Am. J. Kidney Dis.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
  • DENILEUKIN DIFTITOX   IL2RB

    Interaction Score: 18.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Interleukin-2 receptor binding agent
    Direct Interaction yes

    PMIDs:
    18684057 15811959 16516670 11752352 17187516


    Sources:
    ChemblInteractions

  • DENILEUKIN DIFTITOX   IL2RG

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Interleukin-2 receptor binding agent
    Direct Interaction yes

    PMIDs:
    15811959 16516670 11707860


    Sources:
    ChemblInteractions

  • DENILEUKIN DIFTITOX   IL2RA

    Interaction Score: 4.26

    Interaction Types & Directionality:
    binder

    Interaction Info:
    Mechanism of Interaction Interleukin-2 receptor binding agent
    Direct Interaction yes

    PMIDs:
    18684057 2786749 17187516 3124610 11752352 17016423 17139284


    Sources:
    ChemblInteractions

  • DENILEUKIN DIFTITOX   EEF2

    Interaction Score: 3.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Elongation factor 2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ChemblDrugs: chembl:CHEMBL1201550

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1201550

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21