DGIdb - DESVENLAFAXINE Drug Record

DESVENLAFAXINE chembl:CHEMBL1118 Approved

Alternate Names:

PRISTIQ
DESVENLAFAXINE
ODV
KHEDEZLA
O-DESMETHYLVENLAFAXINE
O-DESMETHYLVENLAFAXINE (ODV)
4-[2-(DIMETHYLAMINO)-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENOL
WY-45233
1-[2-(DIMETHYLAMINO)-1-(4-HYDROXYPHENYL)ETHYL]CYCLOHEXANOL
PRISTIQ®
chemidplus:93413-62-8
rxcui:734064
drugbank:06700
chembl:CHEMBL1118
pubchem.compound:125017

Drug Info:

FDA Approval	approved
Drug Class	Small molecule
Drug Indications	for treatment of menopausal symptoms,antidepressant
Year of Approval	2008
Drug Class	antidepressant

(4 More Sources)

Publications:

Reddy et al., 2010, Clinical utility of desvenlafaxine 50 mg/d for treating MDD: a review of two randomized placebo-controlled trials for the practicing physician., Curr Med Res Opin
Liebowitz et al., 2010, Efficacy, safety, and tolerability of Desvenlafaxine 50 mg/d for the treatment of major depressive disorder:a systematic review of clinical trials., Prim Care Companion J Clin Psychiatry
Perry et al., 2009, Desvenlafaxine: a new serotonin-norepinephrine reuptake inhibitor for the treatment of adults with major depressive disorder., Clin Ther
Mason et al., 2007, Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter., J. Pharmacol. Exp. Ther.
Deecher et al., 2006, Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor., J. Pharmacol. Exp. Ther.
Kamath et al., 2008, Desvenlafaxine succinate for major depressive disorder: a critical review of the evidence., Expert Rev Neurother
Montané Jaime LK et al., 2018, Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder., Pharmacogenomics

DESVENLAFAXINE SLC6A2

Interaction Score: 1.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Pristiq

Direct Interaction? True

PMIDs:
19919295 20944767 19698900 17673606 16675639 19086875

Sources:
TdgClinicalTrial TEND GuideToPharmacology
DESVENLAFAXINE SLC6A4

Interaction Score: 1.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Pristiq

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
19919295 20944767 19698900 17673606 16675639 19086875

Sources:
TdgClinicalTrial TEND GuideToPharmacology
DESVENLAFAXINE SLC6A3

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
20944767

Sources:
GuideToPharmacology
DESVENLAFAXINE NAT1

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Norepinephrine transporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DESVENLAFAXINE CYP2D6

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29327975

Sources:
PharmGKB FDA
DESVENLAFAXINE HTT

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin transporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

TEND: DESVENLAFAXINE
- Version: 01-August-2011
Alternate Names:

DESVENLAFAXINE Primary Drug Name

Drug Info:

Drug Class antidepressant

Year of Approval 2008

Publications:
TdgClinicalTrial: DESVENLAFAXINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of menopausal symptoms,antidepressant

Drug Class Small molecule

FDA Approval approved

Publications:
PharmGKB: desvenlafaxine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Montané Jaime LK et al., 2018, Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder., Pharmacogenomics
GuideToPharmacology: 178103733
- Version: 29-September-2020
Alternate Names:

DESVENLAFAXINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Desvenlafaxine
- Version: 2020.06.01
Alternate Names:

D0O3FG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1118
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1118
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Desvenlafaxine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	Pristiq
Direct Interaction?	True

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Mechanism of Interaction	Norepinephrine transporter inhibitor
Direct Interaction	yes

Mechanism of Interaction	Serotonin transporter inhibitor
Direct Interaction	yes

DESVENLAFAXINE Drug Record

DESVENLAFAXINE chembl:CHEMBL1118 Approved

Alternate Names:

Drug Info:

Publications:

DESVENLAFAXINE SLC6A2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Pristiq Direct Interaction? True

PMIDs: 19919295 20944767 19698900 17673606 16675639 19086875

Sources: TdgClinicalTrial TEND GuideToPharmacology

DESVENLAFAXINE SLC6A4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Pristiq Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 19919295 20944767 19698900 17673606 16675639 19086875

Sources: TdgClinicalTrial TEND GuideToPharmacology

DESVENLAFAXINE SLC6A3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 20944767

Sources: GuideToPharmacology

DESVENLAFAXINE NAT1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Norepinephrine transporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

DESVENLAFAXINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29327975

Sources: PharmGKB FDA

DESVENLAFAXINE HTT

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin transporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TEND: DESVENLAFAXINE

Alternate Names: DESVENLAFAXINE Primary Drug Name

Drug Info: Drug Class antidepressant Year of Approval 2008

Publications:

TdgClinicalTrial: DESVENLAFAXINE

Alternate Names:

Drug Info: Drug Indications for treatment of menopausal symptoms,antidepressant Drug Class Small molecule FDA Approval approved

Publications:

PharmGKB: desvenlafaxine

Alternate Names:

Drug Info:

Publications: Montané Jaime LK et al., 2018, Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder., Pharmacogenomics

GuideToPharmacology: 178103733

Alternate Names: DESVENLAFAXINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Desvenlafaxine

Alternate Names: D0O3FG TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1118

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1118

Alternate Names:

Drug Info:

Publications:

FDA: Desvenlafaxine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Pristiq

Direct Interaction? True

PMIDs:
19919295 20944767 19698900 17673606 16675639 19086875

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Pristiq

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
19919295 20944767 19698900 17673606 16675639 19086875

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
20944767

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Norepinephrine transporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
29327975

Sources:
PharmGKB FDA

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin transporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

DESVENLAFAXINE Primary Drug Name

Drug Info:

Drug Class antidepressant

Year of Approval 2008

Drug Info:

Drug Indications for treatment of menopausal symptoms,antidepressant

Drug Class Small molecule

FDA Approval approved

Publications:

Montané Jaime LK et al., 2018, Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder., Pharmacogenomics

Alternate Names:

DESVENLAFAXINE GuideToPharmacology Ligand Name

Alternate Names:

D0O3FG TTD Drug ID