DGIdb - DEXAMETHASONE Drug Record

DEXAMETHASONE chembl:CHEMBL384467 ApprovedAntineoplasticImmunotherapy

Alternate Names:

SPERSADEX COMP
GPPE EAR SPY
OZURDEX
DECADRON
DROPODEX
DEXTENZA
DECADRON-LA
ISV-305
FLUORMETHYLPREDNISOLONE
DEXONE 0.5
DEXACORTISYL
OTO-104
DEXONE 0.75
DEXAFREE
DEXONE 4
MARTAPAN
DECADRON-75
DEXAMETHASONE
DECASPRAY
HEXADROL
DEXAIR
DEXACORT
KORTICO INJECTION
NSC-34521
DEXAMETHASONE METASULFOBENZOATE SODIUM
DEXYCU KIT
OTOMIZE
DEXAMETHASONE INTENSOL
ORADEXON
DEXONE 1.5
NEODECADRON
SOFRADEX
DEXAMETHASONE VALERATE
DEXONE
DECADERM
MAXITROL
DEXACEN-4
DEXAMETHASONE PALMITATE
DALALONE
MYMETHASONE
TOBRADEX
AEROSEB-DEX
DEXSOL
MAXIDEX
DXM833
DESAMETASONE
DECADRON®
chembl:CHEMBL384467
drugbank:01234
rxcui:3264
pubchem.compound:5743
chemidplus:50-02-2

Drug Info:

Drug Class	Small Molecule
FDA Approval	approved
Drug Indications	antiinflammatory agent,glucocorticoid,for treatment of Meniere's disease
Drug Class	anti-inflammatory agents
Year of Approval	approved before 1982
Drug Class	glucocorticoids

(7 More Sources)

Publications:

Hahn et al., 1990, Basement membrane components are potent promoters of rat intestinal epithelial cell differentiation in vitro., Gastroenterology
Smith et al., 2000, Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes., J. Biol. Chem.
Toebak et al., 2008, Differential suppression of dendritic cell cytokine production by anti-inflammatory drugs., Br. J. Dermatol.
Yang JJ et al., 2012, Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia., Blood
Alliot-Licht et al., 2005, Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures., Cell Tissue Res.
Gummow et al., 2006, Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex., Mol. Endocrinol.
Grote et al., 1983, No correlation between binding of glucocorticosteroids to specific cytoplasmic proteins in vivo and enzyme induction in the rat liver., Biochem. J.
Uemura et al., 2006, Renin-angiotensin system is an important factor in hormone refractory prostate cancer., Prostate
Karol SE et al., 2016, Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia., Blood
Teisner et al., 1981, Serum levels of the "pregnancy-zone protein" during short-term prenatal dexamethasone therapy., Acta Obstet Gynecol Scand
Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer
Arany et al., 1993, Interactive effects of nutrients and hormones on the expression of insulin-like growth factor binding protein-1 (IGFBP-1) mRNA and peptide, and IGF I release from isolated adult rat hepatocytes., J. Cell. Physiol.
Brismar et al., 1991, The insulin-like growth factor binding protein-1 in low and high insulin responders before and during dexamethasone treatment., Metab. Clin. Exp.
Nakayama et al., 1994, Dexamethasone enhancement of betaglycan (TGF-beta type III receptor) gene expression in osteoblast-like cells., Exp. Cell Res.
Edwards et al., 1987, Modulation of gamma-glutamyltranspeptidase in normal rat hepatocytes in culture by cell density, epidermal growth factor and agents which alter cell differentiation., Carcinogenesis
Himes BE et al., 2014, RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells., PLoS One
Kumar et al., 1998, Differential regulation of SP-A1 and SP-A2 genes by cAMP, glucocorticoids, and insulin., Am. J. Physiol.
Dulkerian et al., 1996, Regulation of surfactant protein D in human fetal lung., Am. J. Respir. Cell Mol. Biol.
Asabe et al., 1996, Maternal dexamethasone treatment enhances the expression of surfactant apoprotein A in the hypoplastic lung of rabbit fetuses induced by oligohydramnios., J. Pediatr. Surg.
Chroneos et al., 1995, Differential regulation of the mannose and SP-A receptors on macrophages., Am. J. Physiol.
O'Reilly et al., 1988, Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line., Biochim. Biophys. Acta
Liley et al., 1988, Glucocorticoids both stimulate and inhibit production of pulmonary surfactant protein A in fetal human lung., Proc. Natl. Acad. Sci. U.S.A.
O'Reilly et al., 1989, Glucocorticoids regulate surfactant protein synthesis in a pulmonary adenocarcinoma cell line., Am. J. Physiol.
Schellhase et al., 1991, Effects of maternal dexamethasone on expression of SP-A, SP-B, and SP-C in the fetal rat lung., Am. J. Respir. Cell Mol. Biol.
Ohashi et al., 1991, Effect of dexamethasone on pulmonary surfactant metabolism in hyperoxia-treated rat lungs., Pediatr. Res.
Mouhieddine-Gueddiche et al., 2003, Dexamethasone potentiates keratinocyte growth factor-stimulated SP-A and SP-B gene expression in alveolar epithelial cells., Pediatr. Res.
Nakamura et al., 2000, Mechanical strain and dexamethasone selectively increase surfactant protein C and tropoelastin gene expression., Am. J. Physiol. Lung Cell Mol. Physiol.
Butrym A et al., 2015, Polymorphisms within beta-catenin encoding gene affect multiple myeloma development and treatment., Leuk Res
Zhang et al., Shear stress induction of C-type natriuretic peptide (CNP) in endothelial cells is independent of NO autocrine signaling., Ann Biomed Eng
Barbour et al., 1988, Glucocorticoid regulation of the genes encoding thymidine kinase, thymidylate synthase, and ornithine decarboxylase in P1798 cells., Mol. Endocrinol.
Tsukamoto et al., 1989, Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat., Gut
Rhee et al., 1995, c-Myc and cyclin D3 (CcnD3) genes are independent targets for glucocorticoid inhibition of lymphoid cell proliferation., Cancer Res.
Bortolozzi R et al., 2018, Ribociclib, a Cdk4/Cdk6 kinase inhibitor, enhances glucocorticoid sensitivity in B-acute lymphoblastic leukemia (B-All)., Biochem Pharmacol
Lehman-McKeeman et al., 1988, Induction of hepatic metallothioneins determined at isoprotein and messenger RNA levels in glucocorticoid-treated rats., Biochem. J.
Krawiec et al., 2007, AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells., Am. J. Physiol. Endocrinol. Metab.
He et al., 2006, Expression of survivin gene in apoptosis induced by dexamethasone in CEM cells., Zhongguo Dang Dai Er Ke Za Zhi
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Suarez et al., 1995, Expression and modulation of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in skin fibroblasts from patients with type Ib pseudohypoparathyroidism., J. Clin. Endocrinol. Metab.
Grummer et al., 1995, Postnatal rat lung retinoic acid receptor (RAR) mRNA expression and effects of dexamethasone on RAR beta mRNA., Pediatr. Pulmonol.
Wang et al., 2007, Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor., Am. J. Physiol., Cell Physiol.
Funato et al., 2006, Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor., Brain Res.
Grossman et al., 2006, Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects., Ann. N. Y. Acad. Sci.
Vaitkuviene et al., Study of the interaction of 1,4-dihydropyridine derivatives with glucocorticoid hormone receptors from the rat liver., Pharmacol Rep
Warne et al., 2006, Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue., Am. J. Physiol. Endocrinol. Metab.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Bucki R et al., 2010, Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate., Antimicrob Agents Chemother
Batie S et al., 2013, Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists., Bioorg Med Chem
Caperuto et al., 2006, Distinct regulation of IRS proteins in adipose tissue from obese aged and dexamethasone-treated rats., Endocrine
Singer et al., 1994, Relationship of serine/threonine phosphorylation/dephosphorylation signaling to glucocorticoid regulation of tight junction permeability and ZO-1 distribution in nontransformed mammary epithelial cells., J. Biol. Chem.
Ki et al., 2005, Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression., Mol. Cell. Biol.
Lecanda et al., 2000, Differential regulation of cadherins by dexamethasone in human osteoblastic cells., J. Cell. Biochem.
de Waziers et al., 1992, Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao)., Pharmacogenetics
Wang et al., 1995, Effects of dexamethasone on the synthesis, degradation, and secretion of apolipoprotein B in cultured rat hepatocytes., Arterioscler. Thromb. Vasc. Biol.
Yao et al., 1999, Dexamethasone alters arachidonate release from human epithelial cells by induction of p11 protein synthesis and inhibition of phospholipase A2 activity., J. Biol. Chem.
Williams et al., 1975, Acute effects of corticosteroids on thyroid activity in Graves' disease., J. Clin. Endocrinol. Metab.
Yamasaki S et al., 2015, UGT1A1 *6 polymorphism predicts outcome in elderly patients with relapsed or refractory diffuse large B-cell lymphoma treated with carboplatin, dexamethasone, etoposide and irinotecan., Ann Hematol
Testolin et al., 1997, Jun and JNK kinase are activated in thymocytes in response to VM26 and radiation but not glucocorticoids., Exp. Cell Res.
French D et al., 2008, A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group., Blood
Jump et al., 1993, Polyunsaturated fatty acids inhibit S14 gene transcription in rat liver and cultured hepatocytes., Proc. Natl. Acad. Sci. U.S.A.
Hayasaka et al., 1978, Effects of epinephrine, indomethacin, acetylsalicyclic acid, dexamethasone, and cyclic AMP on the in vitro activity of lysosomal hyaluronidase from the rabbit iris., Invest. Ophthalmol. Vis. Sci.
Cheng et al., 1995, Dexamethasone enhances accumulation of cholesteryl esters by human macrophages., Am. J. Physiol.
Li et al., 1995, Effects of dexamethasone, heat shock, and serum responses on the inhibition of Hsc70 synthesis by antisense RNA in NIH 3T3 cells., J. Cell. Physiol.
Yang et al., 2004, Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis., Arthritis Rheum.
Davies et al., 2007, Expression and externalization of annexin 1 in the adrenal gland: structure and function of the adrenal gland in annexin 1-null mutant mice., Endocrinology
Wang et al., 2007, Involvement of annexin I in the dexamethasone-mediated upregulation of A549 cells phagocytosis of apoptotic eosinophils., Immunol. Lett.
Morand et al., 2006, Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1., Mediators Inflamm.
John et al., 2006, Time-specific effects of perinatal glucocorticoid treatment on anterior pituitary morphology, annexin 1 expression and adrenocorticotrophic hormone secretion in the adult female rat., J. Neuroendocrinol.
Ohene-Abuakwa et al., 2005, Two-phase culture in Diamond Blackfan anemia: localization of erythroid defect., Blood
Nishikawa et al., 2005, Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro., Am. J. Pathol.
Saporito et al., 1994, Systemic dexamethasone administration increases septal Trk autophosphorylation in adult rats via an induction of nerve growth factor., Mol. Pharmacol.
Shimizu et al., 1997, Down-regulation of 5-hydroxytryptamine7 receptors by dexamethasone in rat frontocortical astrocytes., J. Neurochem.
Perez-Andreu V et al., 2013, Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse., Nat Genet
Michelini FM et al., 2013, Immunomodulatory activity of an anti-HSV-1 synthetic stigmastane analog., Bioorg Med Chem
Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics
Wuthrich et al., 1993, Effect of dexamethasone, 6-mercaptopurine and cyclosporine A on intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression., Biochem. Pharmacol.
Höfken et al., 1998, Membrane dipeptidase and glutathione are major components of pig pancreatic zymogen granules., Exp. Cell Res.
Wang et al., 2004, Enhanced expression of cytosolic fatty acid binding protein and fatty acid uptake during liver regeneration in rats., Mol. Cell. Biochem.
Rajaraman et al., 2004, Effect of dexamethasone, 2-bromopalmitate and clofibrate on L-FABP mediated hepatoma proliferation., J. Pharm. Pharmacol.
Maeda et al., 2002, TEF-1 transcription factors regulate activity of the mouse mammary tumor virus LTR., Biochem. Biophys. Res. Commun.
Sugimoto et al., 2002, Morphological changes induced by extracellular matrix are correlated with maturation of rat small hepatocytes., J. Cell. Biochem.
Smit et al., 2005, Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2., J. Clin. Endocrinol. Metab.
Muller et al., 2003, Mineralocorticoid effects in the kidney: correlation between alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+., J. Am. Soc. Nephrol.
Mazzucconi et al., 1999, Acquired inhibitor against factor IX in a child: successful treatment with high-dose immunoglobulin and dexamethasone., Haemophilia
Meetze et al., 1993, Ontogeny of small intestinal glutaminase and glutamine synthetase in the rat: response to dexamethasone., Biol. Neonate
Orlikowsky et al., 2005, Effect of dexamethasone on B7 regulation and T cell activation in neonates and adults., Pediatr. Res.
Ebert et al., 2005, An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray., Blood
Vrang et al., 2003, Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids., Brain Res.
Pikman et al., 2017, Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia., Clin. Cancer Res.
Wattanathorn et al., 1996, Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase., Eur. J. Pharmacol.
Kretschmer XC et al., 2005, CAR and PXR: xenosensors of endocrine disrupters?, Chem Biol Interact
Mackiewicz et al., 1993, Leukemia inhibitory factor, interferon gamma and dexamethasone regulate N-glycosylation of alpha 1-protease inhibitor in human hepatoma cells., Eur. J. Cell Biol.
Hundertmark et al., 1999, Effect of epidermal growth factor on enzymes of phospholipid biosynthesis in lung and liver of fetal rat in vivo and in vitro., Horm. Metab. Res.
Chan et al., 1987, Cyclosporine and dexamethasone inhibit T-lymphocyte MHC class II antigens and IL-2 receptor expression in experimental autoimmune uveitis., Immunol. Invest.
Capes-Davis et al., 1999, Glucocorticoids differentially inhibit expression of the RET proto-oncogene., Gene Expr.
Iu et al., 2005, Dexamethasone suppresses Smad3 pathway in osteoblastic cells., J. Endocrinol.
Jakobsen Falk I et al., 2018, Pharmacogenetic study of the impact of ABCB1 single-nucleotide polymorphisms on lenalidomide treatment outcomes in patients with multiple myeloma: results from a phase IV observational study and subsequent phase II clinical trial., Cancer Chemother Pharmacol
Maggini V et al., 2008, MDR1 diplotypes as prognostic markers in multiple myeloma., Pharmacogenet Genomics
Ames SK et al., 1999, Vitamin D receptor gene Fok1 polymorphism predicts calcium absorption and bone mineral density in children., J Bone Miner Res
Elnenaei MO et al., 2011, Genomic and metabolomic patterns segregate with responses to calcium and vitamin D supplementation., Br J Nutr
Jehan F et al., 2008, Vitamin D receptor genotype in hypophosphatemic rickets as a predictor of growth and response to treatment., J Clin Endocrinol Metab
Abrams SA et al., 2005, Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty., J Bone Miner Res
Halsall JA et al., 2005, Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis., Pharmacogenet Genomics
Tran et al., 2005, Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting., Cancer Res.
Haber et al., 1992, Role of glucose transporters in glucocorticoid-induced insulin resistance. GLUT4 isoform in rat skeletal muscle is not decreased by dexamethasone., Diabetes

DEXAMETHASONE RPS19

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15755903

Sources:
NCI
DEXAMETHASONE SDS

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12210718

Sources:
NCI
DEXAMETHASONE TEAD1

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12207913

Sources:
NCI
DEXAMETHASONE S100A10

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10358078

Sources:
NCI
DEXAMETHASONE UBR1

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17264220

Sources:
NCI
DEXAMETHASONE CRISPLD2

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24926665

Sources:
PharmGKB
DEXAMETHASONE ACTC1

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15988617

Sources:
NCI
DEXAMETHASONE TSC22D3

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15728202 12707381

Sources:
NCI
DEXAMETHASONE SFTPA1

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9486201 8969273 8906664 8572233 3382698 3194412 2610267 2015097 2014154 12538780 10781428

Sources:
NCI
DEXAMETHASONE CHKA

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10077342

Sources:
NCI
DEXAMETHASONE FABP1

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15532708 15324484

Sources:
NCI
DEXAMETHASONE KRT19

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15793288

Sources:
NCI
DEXAMETHASONE HYAL2

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
212383

Sources:
NCI
DEXAMETHASONE JUNB

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9024781

Sources:
NCI
DEXAMETHASONE MT1F

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3342021

Sources:
NCI
DEXAMETHASONE TGFBR3

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8143777

Sources:
NCI
DEXAMETHASONE DPEP1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9806799

Sources:
NCI
DEXAMETHASONE CDH17

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10760957

Sources:
NCI
DEXAMETHASONE IRS2

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16943575

Sources:
NCI
DEXAMETHASONE TDO2

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6136271

Sources:
NCI
DEXAMETHASONE PYGL

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007406

Sources:
PharmGKB
DEXAMETHASONE CARTPT

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12591118

Sources:
NCI
DEXAMETHASONE VCAM1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7694584

Sources:
NCI
DEXAMETHASONE THRSP

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8378318

Sources:
NCI
DEXAMETHASONE TJP1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8206910

Sources:
NCI
DEXAMETHASONE PZP

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7246081

Sources:
NCI
DEXAMETHASONE SAG

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3123380

Sources:
NCI
DEXAMETHASONE LOH19CR1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15238419

Sources:
NCI
DEXAMETHASONE SOAT1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7485476

Sources:
NCI
DEXAMETHASONE SI

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2295387

Sources:
NCI
DEXAMETHASONE ANXA1

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
15022342 17158208 17644190 16883066 17076770

Sources:
NCI TEND
DEXAMETHASONE IGFBP1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7683312 1714534

Sources:
NCI
DEXAMETHASONE CD86

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15718366

Sources:
NCI
DEXAMETHASONE F9

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10215963

Sources:
NCI
DEXAMETHASONE CCL17

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18028503

Sources:
NCI
DEXAMETHASONE PTH1R

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7883858

Sources:
NCI
DEXAMETHASONE NR5A1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16857744

Sources:
NCI
DEXAMETHASONE FOLR1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15899836

Sources:
NCI
DEXAMETHASONE CHAT

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8905330

Sources:
NCI
DEXAMETHASONE BMP7

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26590194

Sources:
PharmGKB
DEXAMETHASONE LINC00251

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26590194

Sources:
PharmGKB
DEXAMETHASONE NPPC

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10468226

Sources:
NCI
DEXAMETHASONE DOK5

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26590194

Sources:
PharmGKB
DEXAMETHASONE LIF

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8392465

Sources:
NCI
DEXAMETHASONE GATA3

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24141364

Sources:
PharmGKB
DEXAMETHASONE HSPA8

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7542664

Sources:
NCI
DEXAMETHASONE CDK4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7664296 29408328

Sources:
NCI CIViC
DEXAMETHASONE NOTCH1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Ribociclib + Dexamethasone

Indication/Tumor Type T-cell adult acute lymphocytic leukemia

Response Type sensitive

PMIDs:
28151717

Sources:
JAX-CKB
DEXAMETHASONE CDK6

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29408328

Sources:
CIViC
DEXAMETHASONE CTLA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB
DEXAMETHASONE TG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1174132

Sources:
NCI
DEXAMETHASONE APOB

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7670964

Sources:
NCI
DEXAMETHASONE GGT1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2890444

Sources:
NCI
DEXAMETHASONE TYMS

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3398844 2707640

Sources:
NCI PharmGKB
DEXAMETHASONE NR3C1

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16971495 16956592 16891588 16963802 16835395 11752352 20308375 23276449

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
DEXAMETHASONE CTNNB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26521987

Sources:
PharmGKB
DEXAMETHASONE SERPINE1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18285546

Sources:
PharmGKB
DEXAMETHASONE RB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Ribociclib + Dexamethasone

Indication/Tumor Type T-cell adult acute lymphocytic leukemia

Response Type sensitive

PMIDs:
28151717

Sources:
JAX-CKB
DEXAMETHASONE NRG1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7599067

Sources:
NCI
DEXAMETHASONE TYMSOS

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DEXAMETHASONE RARA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8606853

Sources:
NCI
DEXAMETHASONE BIRC5

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16787583

Sources:
NCI
DEXAMETHASONE UGT1A1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25055799

Sources:
PharmGKB
DEXAMETHASONE SLC2A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1587399

Sources:
NCI
DEXAMETHASONE NR3C2

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DEXAMETHASONE HTR7

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9166758

Sources:
NCI
DEXAMETHASONE GSTP1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1302037

Sources:
NCI
DEXAMETHASONE AGTR1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16482568

Sources:
NCI
DEXAMETHASONE RELA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23219855

Sources:
DTC
DEXAMETHASONE NTRK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8145726

Sources:
NCI
DEXAMETHASONE RET

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10947080

Sources:
NCI
DEXAMETHASONE GLS

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7904483

Sources:
NCI
DEXAMETHASONE CDK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10867026

Sources:
NCI
DEXAMETHASONE NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16054614

Sources:
PharmGKB
DEXAMETHASONE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10320522 20727239 18827005 15883634 15864137

Sources:
PharmGKB
DEXAMETHASONE ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29177954 18408561

Sources:
PharmGKB
DEXAMETHASONE SMAD3

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15817834

Sources:
NCI
DEXAMETHASONE CYP2C9

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DEXAMETHASONE CYP2C19

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DEXAMETHASONE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15870285

Sources:
DTC NCI
DEXAMETHASONE CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DEXAMETHASONE CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DEXAMETHASONE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DEXAMETHASONE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DEXAMETHASONE
- Version: 01-August-2011
Alternate Names:

DEXAMETHASONE Primary Drug Name

Drug Info:

Drug Class glucocorticoids

Year of Approval approved before 1982

Drug Class anti-inflammatory agents

Publications:
TdgClinicalTrial: DEXAMETHASONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent,glucocorticoid,for treatment of Meniere's disease

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: DEXAMETHASONE

Version: 14-September-2017

Alternate Names:

C422 NCI drug code

Drug Info:

Publications:

Hahn et al., 1990, Basement membrane components are potent promoters of rat intestinal epithelial cell differentiation in vitro., Gastroenterology

Smith et al., 2000, Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes., J. Biol. Chem.

Toebak et al., 2008, Differential suppression of dendritic cell cytokine production by anti-inflammatory drugs., Br. J. Dermatol.

DTC: DEXAMETHASONE

Version: 02-September-2020

Alternate Names:

CHEMBL384467 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Batie S et al., 2013, Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists., Bioorg Med Chem

Bucki R et al., 2010, Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate., Antimicrob Agents Chemother

PharmGKB: dexamethasone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

French D et al., 2008, A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group., Blood

Karol SE et al., 2016, Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia., Blood

Abrams SA et al., 2005, Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty., J Bone Miner Res

JAX-CKB: Dexamethasone
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Pikman et al., 2017, Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia., Clin. Cancer Res.
CIViC: DEXAMETHASONE
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Bortolozzi R et al., 2018, Ribociclib, a Cdk4/Cdk6 kinase inhibitor, enhances glucocorticoid sensitivity in B-acute lymphoblastic leukemia (B-All)., Biochem Pharmacol
GuideToPharmacology: 135651471
- Version: 29-September-2020
Alternate Names:

DEXAMETHASONE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Dexamethasone
- Version: 2020.06.01
Alternate Names:

D0IT2G TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL384467
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL384467
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

combination therapy	Ribociclib + Dexamethasone
Indication/Tumor Type	T-cell adult acute lymphocytic leukemia
Response Type	sensitive

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	True

DEXAMETHASONE Drug Record

DEXAMETHASONE chembl:CHEMBL384467 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15755903

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12210718

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12207913

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10358078

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17264220

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24926665

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15988617

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15728202 12707381

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9486201 8969273 8906664 8572233 3382698 3194412 2610267 2015097 2014154 12538780 10781428

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10077342

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15532708 15324484

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15793288

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 212383

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9024781

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3342021

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8143777

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9806799

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10760957

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16943575

Interaction Types & Directionality:

n/a

PMIDs:
15755903

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12210718

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12207913

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10358078

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17264220

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24926665

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15988617

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15728202 12707381

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9486201 8969273 8906664 8572233 3382698 3194412 2610267 2015097 2014154 12538780 10781428

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10077342

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15532708 15324484

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15793288

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
212383

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9024781

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3342021

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8143777

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9806799

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10760957

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16943575

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6136271

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23007406

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12591118

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7694584

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8378318

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8206910

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7246081

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3123380