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DEXTROTHYROXINE Drug Record

  • Summary
  • Interactions
  • Claims
  • DEXTROTHYROXINE chembl:CHEMBL559 Approved

    Alternate Names:

    CHOLOXIN
    LIOTRIX
    THYROXINE
    D-THYROXINE
    DEXTROTHYROXINE
    CHOLOXIN®
    O-(4-HYDROXY-3,5-DIIODOPHENYL)-3,5-DIIODO-D-TYROSINE
    D-T4
    DT4
    chembl:CHEMBL559
    rxcui:3292
    pubchem.compound:8730
    drugbank:00509
    chemidplus:51-49-0

    Drug Info:

    (0 More Sources)

    Publications:

    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Yen et al., 2003, Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice., EMBO Rep.
    Bernal, 2007, Thyroid hormone receptors in brain development and function., Nat Clin Pract Endocrinol Metab
    González-Sancho et al., 2003, Thyroid hormone receptors/THR genes in human cancer., Cancer Lett.
    Wu et al., 2005, Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T)., J. Lab. Clin. Med.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Mai et al., 2004, Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life., Proc. Natl. Acad. Sci. U.S.A.
    Timmer et al., 2003, Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA., J. Endocrinol.
    Sciaudone et al., 2004, Diethylenetriaminepentaacetic acid enhances thyroid hormone action by a transcriptional mechanism., Biol Trace Elem Res
    Jiang et al., 2004, Expression of thyroid hormone receptor alpha in 3T3-L1 adipocytes; triiodothyronine increases the expression of lipogenic enzyme and triglyceride accumulation., J. Endocrinol.
    Kariv et al., 2003, Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line., Liver Int.
  • DEXTROTHYROXINE   THRA

    Interaction Score: 16.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Thyroid hormone receptor agonist
    Direct Interaction yes

    PMIDs:
    15240882 14596673 17315033 15235154 15283690 12955882


    Sources:
    ChemblInteractions

  • DEXTROTHYROXINE   THRB

    Interaction Score: 1.68

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Thyroid hormone receptor agonist
    Direct Interaction yes

    PMIDs:
    10592235 12776178 17315033 12668276 16099238 17016423 17139284


    Sources:
    ChemblInteractions

  • DEXTROTHYROXINE   CYP2C9

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DTC: DEXTROTHYROXINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL559 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL559

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL559

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21