DGIdb - DIACETYLMORPHINE HYDROCHLORIDE Drug Record

DIACETYLMORPHINE HYDROCHLORIDE chembl:CHEMBL2106627 Approved

Alternate Names:

DIAMORPHINE
NSC-302357
DIACETYLMORPHINE HYDROCHLORIDE CI
DIAMORPHINE HYDROCHLORIDE
HEROIN HCL
DIACETYLMORPHINE HCL

Drug Info:

Drug Type	small molecule
Drug Groups	approved
Drug Groups	illicit
Drug Groups	investigational
Drug Categories	alkaloids
Drug Categories	analgesics
Drug Categories	central nervous system agents
Drug Categories	central nervous system depressants
Drug Categories	drugs used in addictive disorders
Drug Categories	drugs used in opioid dependence
Drug Categories	heroin, agonists
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	morphinans
Drug Categories	morphine derivatives
Drug Categories	narcotics
Drug Categories	nervous system
Drug Categories	opiate alkaloids
Drug Categories	opioids
Drug Categories	peripheral nervous system agents
Drug Categories	phenanthrenes
Drug Categories	sensory system agents
Drug Categories	thyroxine-binding globulin inducers

(0 More Sources)

Publications:

Kieffer et al., 2002, Exploring the opioid system by gene knockout., Prog. Neurobiol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Klein et al., 2008, Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors., Eur. J. Pharmacol.
Choi et al., 2006, The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor., Biochem. Biophys. Res. Commun.
Greenwald et al., 2003, Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers., Neuropsychopharmacology
Yao et al., 2005, Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior., Proc. Natl. Acad. Sci. U.S.A.
Antonilli et al., 2005, Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat., Psychopharmacology (Berl.)
Becker et al., 2004, MOR1 receptor mRNA expression in human brains of drug-related fatalities-a real-time PCR quantification., Forensic Sci. Int.
Wee et al., 2010, The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse., Psychopharmacology (Berl.)
Brzezinski MR et al., 1997, Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs., Drug Metab Dispos

DIACETYLMORPHINE HYDROCHLORIDE CES1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9311626

Sources:
DrugBank
DIACETYLMORPHINE HYDROCHLORIDE OPRD1

Interaction Score: 0.68

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
12015197 11752352 18343363

Sources:
DrugBank
DIACETYLMORPHINE HYDROCHLORIDE OPRM1

Interaction Score: 0.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16580639 12902992 15937104 15986196 15013161

Sources:
DrugBank
DIACETYLMORPHINE HYDROCHLORIDE OPRK1

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20352414 18343363

Sources:
DrugBank

DrugBank: DB01452

Version: 5.1.7

Alternate Names:

DIAMORPHINE DrugBank Drug Name

561-27-3 CAS Number

Diamorphine Hydrochloride Inj 100mg/ml BP Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups illicit

Publications:

Kieffer et al., 2002, Exploring the opioid system by gene knockout., Prog. Neurobiol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Klein et al., 2008, Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors., Eur. J. Pharmacol.

ChemblDrugs: chembl:CHEMBL2106627
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

DIAMORPHINE	DrugBank Drug Name
561-27-3	CAS Number
Diamorphine Hydrochloride Inj 100mg/ml BP	Drug Brand

DIACETYLMORPHINE HYDROCHLORIDE Drug Record

DIACETYLMORPHINE HYDROCHLORIDE chembl:CHEMBL2106627 Approved

Alternate Names:

Drug Info:

Publications:

DIACETYLMORPHINE HYDROCHLORIDE CES1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9311626

Sources: DrugBank

DIACETYLMORPHINE HYDROCHLORIDE OPRD1

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 12015197 11752352 18343363

Sources: DrugBank

DIACETYLMORPHINE HYDROCHLORIDE OPRM1

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 16580639 12902992 15937104 15986196 15013161

Sources: DrugBank

DIACETYLMORPHINE HYDROCHLORIDE OPRK1

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 20352414 18343363

Sources: DrugBank

DrugBank: DB01452

Alternate Names: DIAMORPHINE DrugBank Drug Name 561-27-3 CAS Number Diamorphine Hydrochloride Inj 100mg/ml BP Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups illicit

ChemblDrugs: chembl:CHEMBL2106627

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
9311626

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
12015197 11752352 18343363

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
16580639 12902992 15937104 15986196 15013161

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
20352414 18343363

Sources:
DrugBank

Alternate Names:

DIAMORPHINE DrugBank Drug Name

561-27-3 CAS Number

Diamorphine Hydrochloride Inj 100mg/ml BP Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups illicit