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DIAZEPAM Drug Record

  • Summary
  • Interactions
  • Claims
  • DIAZEPAM chembl:CHEMBL12 Approved

    Alternate Names:

    ALUPRAM 5
    ALUPRAM 2
    DIALAR FTE
    DIASTAT
    RELANIUM
    VALIUM
    SOLIS
    LA-III
    E-PAM
    DIAZEPAM INTENSOL
    RO-5-2807
    RO-52807
    STESOLID
    SERENACK
    TRANIMUL
    DIZAC
    Q-PAM
    PAXEL
    VALRELEASE
    DIASTAT ACUDIAL
    APOZEPAM
    VIVOL
    ATENSINE
    WY-3467
    NSC-77518
    DIAZEPAM CIV
    TENSIUM
    DIAZEPAM
    ALUPRAM 10
    SCRIPTOPAM
    NSC-169897
    DIALAR
    VALCLAIR
    METHYL DIAZEPINONE
    VALIUM®
    DIASTAT®
    7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE
    rxcui:3322
    chembl:CHEMBL12
    drugbank:00829
    chemidplus:439-14-5
    pubchem.compound:3016

    Drug Info:

    Drug Class hypnotics and sedatives
    Year of Approval 1963
    Drug Class Small Molecule
    Drug Indications anticonvulsant
    FDA Approval approved
    (5 More Sources)

    Publications:

    Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.
    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
    Naftalin et al., 2004, Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepam, melatonin and galanin of human erythrocyte D-glucose transport., Br. J. Pharmacol.
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Derry et al., 2004, Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding., J. Neurochem.
    Falchi et al., 2007, Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands., Neuropharmacology
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
    Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
    Dorado P et al., 2013, Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms., Pharmacogenomics J
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Costall et al., 1991, Anxiolytic effects of CCK-B antagonists., Neuropeptides
    Buttar D et al., 2010, A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions., Bioorg Med Chem
    Altikat et al., In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase., Pol J Pharmacol
    Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics
    Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics
  • DIAZEPAM   SLC2A1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15148255


    Sources:
    NCI

  • DIAZEPAM   GABRR3

    Interaction Score: 0.33

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name diazepam rectal gel
    Novel drug target Established target
    Trial Name NRL-01

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • DIAZEPAM   GABRR2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name diazepam rectal gel
    Novel drug target Established target
    Trial Name NRL-01

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • DIAZEPAM   GABRR1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name diazepam rectal gel
    Novel drug target Established target
    Trial Name NRL-01

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • DIAZEPAM   CCKBR

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1679211


    Sources:
    NCI

  • DIAZEPAM   TSPO

    Interaction Score: 0.24

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    17631921 11752352


    Sources:
    TEND TTD

  • DIAZEPAM   ALB

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20869876


    Sources:
    DTC

  • DIAZEPAM   GABRQ

    Interaction Score: 0.19

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name diazepam rectal gel

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRA1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name diazepam rectal gel

    PMIDs:
    15009644 11752090 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRE

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name diazepam rectal gel

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRP

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name diazepam rectal gel
    Novel drug target Established target
    Trial Name NRL-01

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRA5

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name diazepam rectal gel
    Novel drug target Established target
    Trial Name NRL-01

    PMIDs:
    15009644 11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRD

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name diazepam rectal gel

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRB3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name diazepam rectal gel
    Novel drug target Established target
    Trial Name NRL-01

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRG1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name NRL-01

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRB1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name diazepam rectal gel

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRA3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Trial Name diazepam rectal gel
    Novel drug target Established target
    Trial Name NRL-01

    PMIDs:
    15009644 11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRA2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name diazepam rectal gel

    PMIDs:
    15009644 11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRB2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name diazepam rectal gel

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRG3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name NRL-01
    Novel drug target Established target
    Trial Name diazepam rectal gel

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   CYP2B6

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11470993 17638512


    Sources:
    PharmGKB

  • DIAZEPAM   GABRG2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    11752090 18384456


    Sources:
    ChemblInteractions TEND

  • DIAZEPAM   G6PD

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12020046


    Sources:
    NCI

  • DIAZEPAM   CYP3A5

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • DIAZEPAM   GABRA4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIAZEPAM   GABRA6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIAZEPAM   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22641027


    Sources:
    PharmGKB

  • DIAZEPAM   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • DIAZEPAM   CYP2C19

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • DIAZEPAM   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: DIAZEPAM

    • Version: 01-August-2011

    Alternate Names:
    DIAZEPAM Primary Drug Name

    Drug Info:
    Year of Approval 1963
    Drug Class hypnotics and sedatives

    Publications:

  • TdgClinicalTrial: DIAZEPAM

    • Version: January-2014

    Alternate Names:

    Drug Info:
    FDA Approval approved
    Drug Indications anticonvulsant
    Drug Class Small Molecule

    Publications:

  • NCI: DIAZEPAM

    • Version: 14-September-2017

    Alternate Names:
    C28982 NCI drug code

    Drug Info:

    Publications:
    Naftalin et al., 2004, Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepam, melatonin and galanin of human erythrocyte D-glucose transport., Br. J. Pharmacol.
    Costall et al., 1991, Anxiolytic effects of CCK-B antagonists., Neuropeptides
    Altikat et al., In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase., Pol J Pharmacol

  • DTC: DIAZEPAM

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL12 ChEMBL Drug ID

    Drug Info:

    Publications:
    Buttar D et al., 2010, A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions., Bioorg Med Chem

  • PharmGKB: diazepam

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Dorado P et al., 2013, Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms., Pharmacogenomics J
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Diazepam

    • Version: 2020.06.01

    Alternate Names:
    D07JVL TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL12

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL12

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Diazepam

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21