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DIPHENHYDRAMINE Drug Record

  • Summary
  • Interactions
  • Claims
  • DIPHENHYDRAMINE chembl:CHEMBL657 Approved

    Alternate Names:

    HYDRAMINE
    DIPHENHYDRAMINE
    SILPHEN
    DIBENIL
    ANTITUSSIVE
    BELIX
    DIPHEN
    BELDIN
    BENYLIN
    BENADRYL
    BENADRYL®
    BENZHYDRAMINE
    O-BENZHYDRYLDIMETHYLAMINOETHANOL
    DIMEHYDRINATE
    DIMEDROLUM
    BENDYLATE
    DIFENHYDRAMINE
    ALLEDRYL
    ALLERGINA
    N-(2-(DIPHENYLMETHOXY)ETHYL)-N,N-DIMETHYLAMINE
    ALPHA-(2-DIMETHYLAMINOETHOXY)DIPHENYLMETHANE
    DIMEDROL
    DIPHANTINE
    DIPHAMINE
    2-DIPHENYLMETHOXY-N,N-DEMTHYLETHANAMINE
    BENZANTIN
    2-(BENZHYDRYLOXY)-N,N-DIMETHYLETHYLAMINE
    DOBACEN
    ALLERGAN
    BETA-DIMETHYLAMINOETHANOL DIPHENYLMETHYL ETHER
    [2-(DIPHENYLMETHOXY)ETHYL]DIMETHYLAMINE
    BETA-DIMETHYLAMINOETHYL BENZHYDRYL ETHER
    DIMETHYLAMINE BENZHYDRYL ESTER
    pubchem.compound:3100
    drugbank:01075
    rxcui:3498
    rxcui:486577
    chemidplus:58-73-1
    chembl:CHEMBL657

    Drug Info:

    Drug Categories sleep aids, pharmaceutical
    FDA Approval 1946
    Drug Class small molecule
    Drug Indications Antitussives
    Drug Indications Antipruritics
    Drug Indications Antiemetics
    Drug Indications Hypnotics and sedatives
    Drug Indications Anti-Allergic Agents
    Drug Class antiemetics
    Year of Approval 1946
    Drug Class antipruritics
    Drug Class hypnotics and sedatives
    Drug Class antitussives
    Drug Class anti-allergic agents
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Groups investigational
    Drug Categories agents producing tachycardia
    Drug Categories anticholinergic agents
    Drug Categories antihistamines for topical use
    Drug Categories antipruritics, incl. antihistamines, anesthetics, etc.
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 substrates
    Drug Categories dermatologicals
    Drug Categories drugs causing inadvertant photosensitivity
    Drug Categories ethanolamine derivatives
    Drug Categories first generation antihistamines
    Drug Categories muscarinic antagonists
    Drug Categories oct2 inhibitors
    Drug Categories photosensitizing agents
    Drug Categories potential qtc-prolonging agents
    Drug Categories qtc prolonging agents
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    (3 More Sources)

    Publications:

    Hasala et al., First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis., Allergy Asthma Proc
    Ishikawa et al., 2007, Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats., Biol. Pharm. Bull.
    Piao et al., 2007, Potentiation by neuropeptide Y of histamine H1 receptor-mediated contraction in rat blood vessels., Vascul. Pharmacol.
    Havas et al., 1986, The effects of combined H1 and H2 histamine antagonists on alterations in nasal airflow resistance induced by topical histamine provocation., J. Allergy Clin. Immunol.
    Wang et al., 2007, Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects., Eur. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kesiova et al., Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues., Pharmacol Rep
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Liu et al., 2006, Antimuscarinic actions of antihistamines on the heart., J. Biomed. Sci.
  • DIPHENHYDRAMINE   HNMT

    Interaction Score: 0.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DIPHENHYDRAMINE   HRH1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Specific Action of the Ligand Antagonist

    PMIDs:
    17390763 17329841 17169617 2878016 17196194 11752352 16702624


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • DIPHENHYDRAMINE   CHRM2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    16453179


    Sources:
    DrugBank

  • DIPHENHYDRAMINE   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DIPHENHYDRAMINE   CYP2C19

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DIPHENHYDRAMINE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DIPHENHYDRAMINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DIPHENHYDRAMINE   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DrugBank: DB01075

    • Version: 5.1.7

    Alternate Names:
    7 Select Pain Relief PM Drug Brand
    7-Select Advil PM Drug Brand
    Acedif PLUS Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Liu et al., 2006, Antimuscarinic actions of antihistamines on the heart., J. Biomed. Sci.
    Hasala et al., First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis., Allergy Asthma Proc
    Ishikawa et al., 2007, Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats., Biol. Pharm. Bull.

  • TEND: DIPHENHYDRAMINE

    • Version: 01-August-2011

    Alternate Names:
    DIPHENHYDRAMINE Primary Drug Name

    Drug Info:
    Drug Class anti-allergic agents
    Drug Class antitussives
    Drug Class hypnotics and sedatives

    Publications:

  • TdgClinicalTrial: DIPHENHYDRAMINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-Allergic Agents
    Drug Indications Hypnotics and sedatives
    Drug Indications Antiemetics

    Publications:

  • DTC: DIPHENHYDRAMINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL657 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Diphenhydramine

    • Version: 2020.06.01

    Alternate Names:
    D01FGR TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135650192

    • Version: 29-September-2020

    Alternate Names:
    DIPHENHYDRAMINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL657

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13