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DOXYCYCLINE Drug Record

  • Summary
  • Interactions
  • Claims
  • DOXYCYCLINE chembl:CHEMBL1433 ApprovedAntineoplastic

    Alternate Names:

    GS-3065
    DOXYCYCLINE
    DOXYCYCLINE ANHYDROUS
    6ALPHA-DEOXY-5-OXYTETRACYCLINE
    ORACEA
    VIBROX
    MICRODOX
    DOXYCYCLIN
    DOXYCYCLINUM
    5-HYDROXY-ALPHA-6-DEOXYTETRACYCLINE
    DOXICICLINA
    IVDOX
    DOXYCYCLINE (ANHYDROUS)
    ANHYDROUS DOXYCYCLINE
    VIBRAVENOS
    DOXORAL
    DOXYHEXAL
    MONODOX
    JENACYCLIN
    PERIOSTAT
    ADOXA
    5-HYDROXY-Α-6-DEOXYTETRACYCLINE
    6Α-DEOXY-5-OXYTETRACYCLINE
    6-ALPHA-DEOXY-5-OXYTETRACYCLINE
    SUPRACYCLIN
    VIBRAMYCIN
    DORYX
    LIVIATIN
    (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE
    DOXYLIN
    drugbank:00254
    chembl:CHEMBL1433
    pubchem.compound:54671203
    rxcui:3640
    chemidplus:564-25-0
    rxcui:1545992

    Drug Info:

    (2 More Sources)

    Publications:

    Georgievska et al., 2004, Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector., Hum. Gene Ther.
    Li et al., 2006, JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells., Exp. Eye Res.
    Kim et al., 2005, Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells., Invest. Ophthalmol. Vis. Sci.
    Mealey et al., 2002, Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells., Antimicrob. Agents Chemother.
    Iakovleva et al., [In vitro induced activity of polymorphonuclear leukocyte myeloperoxidase at different stages of opisthorchis invasion and at stages of a different rehabilitative period]., Med Parazitol (Mosk)
    De Paiva et al., 2006, Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye., Exp. Eye Res.
    Ishikawa C et al., 2009, Tetracyclines modulate protease-activated receptor 2-mediated proinflammatory reactions in epidermal keratinocytes., Antimicrob Agents Chemother
    Toy et al., 2013, ESR1 ligand-binding domain mutations in hormone-resistant breast cancer., Nat. Genet.
  • DOXYCYCLINE   SOD1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOXYCYCLINE   F2RL1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19258275


    Sources:
    DTC

  • DOXYCYCLINE   TH

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15585109


    Sources:
    NCI

  • DOXYCYCLINE   MPO

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14564835


    Sources:
    NCI

  • DOXYCYCLINE   MAPK8

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16202406 15728539


    Sources:
    NCI

  • DOXYCYCLINE   NOS2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenomeClinicalTrial

  • DOXYCYCLINE   MAPK14

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16643899


    Sources:
    NCI

  • DOXYCYCLINE   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11850258


    Sources:
    NCI PharmGKB

  • DOXYCYCLINE   ESR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24185512


    Sources:
    PharmGKB

  • DOXYCYCLINE   NR1I2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOXYCYCLINE   FEN1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOXYCYCLINE   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DTC: DOXYCYCLINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1433 ChEMBL Drug ID

    Drug Info:

    Publications:
    Ishikawa C et al., 2009, Tetracyclines modulate protease-activated receptor 2-mediated proinflammatory reactions in epidermal keratinocytes., Antimicrob Agents Chemother

  • NCI: DOXYCYCLINE

    • Version: 14-September-2017

    Alternate Names:
    C457 NCI drug code

    Drug Info:

    Publications:
    Iakovleva et al., [In vitro induced activity of polymorphonuclear leukocyte myeloperoxidase at different stages of opisthorchis invasion and at stages of a different rehabilitative period]., Med Parazitol (Mosk)
    Mealey et al., 2002, Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells., Antimicrob. Agents Chemother.
    Li et al., 2006, JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells., Exp. Eye Res.

  • PharmGKB: doxycycline

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Toy et al., 2013, ESR1 ligand-binding domain mutations in hormone-resistant breast cancer., Nat. Genet.

  • TTD: Doxycycline

    • Version: 2020.06.01

    Alternate Names:
    D0S0LZ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1433

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • MyCancerGenomeClinicalTrial: DOXYCYCLINE

    • Version: 30-February-2014

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21