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DROXIDOPA Drug Record

  • Summary
  • Interactions
  • Claims
  • DROXIDOPA chembl:CHEMBL2103827 Approved

    Alternate Names:

    NORTHERA
    L-DOPS
    DROXIDOPA
    DOPS
    L-DIHYDROXYPHENYLSERINE
    (-)-(2S,3R)-2-AMINO-3-HYDROXY-3-(3,4-DIHYDROXYPHENYL)PROPANOIC ACID
    NORTHERA®
    SM 5688
    L-THREO-DIHYDROXYPHENYLSERINE
    L-THREODOPS
    DROXYDOPA
    SM-5688
    (2S,3R)-3,4-DIHYDROXY-PHENYLSERINE
    THREO-DOPASERINE
    chembl:CHEMBL2103827
    chemidplus:23651-95-8
    rxcui:1489913
    drugbank:06262
    pubchem.compound:92974

    Drug Info:

    (0 More Sources)

    Publications:

    Testa et al., 1995, Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype., Br. J. Pharmacol.
    Du et al., 2010, Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists., Curr Comput Aided Drug Des
    Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
    Izzo et al., 1994, Regulation of alpha 1B-adrenergic receptor half-life: protein synthesis dependence and effect of norepinephrine., Am. J. Physiol.
    Tarizzo et al., 1994, Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat., Naunyn Schmiedebergs Arch. Pharmacol.
    Mersmann, 1998, Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action., J. Anim. Sci.
    El-Armouche et al., 2009, Beta-adrenergic stimulation and myocardial function in the failing heart., Heart Fail Rev
    Sanders, 1998, The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2, and B lymphocyte function., Adv. Exp. Med. Biol.
    Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
    Senard et al., 2001, Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management., Drugs Aging
    Lachnit et al., 1997, Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat., Br. J. Pharmacol.
    Burt et al., 1996, The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens., Br. J. Pharmacol.
    Giovannoni et al., 2009, Alpha2-agonists as analgesic agents., Med Res Rev
    Davis, 2010, Recent advances in the treatment of pain., F1000 Med Rep
    Nyrönen et al., 2001, Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine., Mol. Pharmacol.
    Coman et al., 2009, Beta 3 adrenergic receptors: molecular, histological, functional and pharmacological approaches., Rom J Morphol Embryol
    Rump et al., 1995, Alpha 2C-adrenoceptor-modulated release of noradrenaline in human right atrium., Br. J. Pharmacol.
  • DROXIDOPA   ADRB3

    Interaction Score: 1.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    19110970 9464897 19434307 18064417


    Sources:
    ChemblInteractions

  • DROXIDOPA   ADRA1B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    7773533 20412040 17266602 8166240


    Sources:
    ChemblInteractions

  • DROXIDOPA   ADRA2B

    Interaction Score: 0.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    18680204 18064417 21173850


    Sources:
    ChemblInteractions

  • DROXIDOPA   ADRA1A

    Interaction Score: 0.53

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    11482743 9138687 20412040 8825367 17266602


    Sources:
    ChemblInteractions

  • DROXIDOPA   ADRA2C

    Interaction Score: 0.5

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    18680204 8590979 21173850


    Sources:
    ChemblInteractions

  • DROXIDOPA   ADRA2A

    Interaction Score: 0.44

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    18680204 21173850 11306720


    Sources:
    ChemblInteractions

  • DROXIDOPA   ADRB1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    19110970 9464897 18064417


    Sources:
    ChemblInteractions

  • DROXIDOPA   ADRB2

    Interaction Score: 0.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    7969507 9464897 19110970 9666280 18064417


    Sources:
    ChemblInteractions

  • ChemblDrugs: chembl:CHEMBL2103827

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL2103827

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21