DGIdb - DULOXETINE Drug Record

DULOXETINE chembl:CHEMBL1175 Approved

Alternate Names:

DULOXETINE
LY248686
LY-248686
CYMBALTA
CYMBALTA®
(S)-DULOXETINE
LY 248686
(3S)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPAN-1-AMINE
drugbank:00476
pubchem.compound:60835
rxcui:72625
chemidplus:116539-59-4
chembl:CHEMBL1175

Drug Info:

Year of Approval	2004
Drug Class	antidepressive agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antidepressant

(3 More Sources)

Publications:

Hunziker et al., 2005, Duloxetine hydrochloride: a new dual-acting medication for the treatment of major depressive disorder., Clin Ther
Karpa et al., 2002, Duloxetine pharmacology: profile of a dual monoamine modulator., CNS Drug Rev
Gould et al., 2007, Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain., Biol. Psychiatry
Trivedi et al., 2008, Clinical evidence for serotonin and norepinephrine reuptake inhibition of duloxetine., Int Clin Psychopharmacol
Chen et al., 2005, The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors., Eur Neuropsychopharmacol
Troelsen et al., 2005, Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter., Psychopharmacology (Berl.)
van Groeningen et al., 1989, Lack of effectiveness of combined 5-fluorouracil and leucovorin in patients with 5-fluorouracil-resistant advanced colorectal cancer., Eur J Cancer Clin Oncol
Vaishnavi et al., 2004, Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity., Biol. Psychiatry
Jost et al., 2004, Duloxetine: mechanism of action at the lower urinary tract and Onuf's nucleus., Clin. Auton. Res.
Mirza et al., 2007, Serotonin transporter density and anxiolytic-like effects of antidepressants in mice., Prog. Neuropsychopharmacol. Biol. Psychiatry
Bymaster et al., 2005, The dual transporter inhibitor duloxetine: a review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression., Curr. Pharm. Des.
Khullar et al., 2010, Mixed incontinence: current evidence and future perspectives., Neurourol. Urodyn.
Carter et al., 2009, Duloxetine: a review of its use in the treatment of generalized anxiety disorder., CNS Drugs
Béïque et al., 1998, Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters., Eur. J. Pharmacol.
Maciukiewicz M et al., 2018, GWAS-based machine learning approach to predict duloxetine response in major depressive disorder., J Psychiatr Res
Maciukiewicz M et al., 2018, Genome-wide association studies of placebo and duloxetine response in major depressive disorder., Pharmacogenomics J
Schou et al., 2005, Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2., Eur Neuropsychopharmacol
Vincent et al., 2004, Clinical assessment of norepinephrine transporter blockade through biochemical and pharmacological profiles., Circulation
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Perlis RH et al., 2013, Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder., Pharmacogenomics J

DULOXETINE ZNF385D

Interaction Score: 10.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288 28696415

Sources:
PharmGKB
DULOXETINE MIEF2

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288

Sources:
PharmGKB
DULOXETINE NRXN1

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288

Sources:
PharmGKB
DULOXETINE ATP10A

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288

Sources:
PharmGKB
DULOXETINE TTC37

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288

Sources:
PharmGKB
DULOXETINE INVS

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288

Sources:
PharmGKB
DULOXETINE FCN2

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288

Sources:
PharmGKB
DULOXETINE TEX10

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288

Sources:
PharmGKB
DULOXETINE KMT2E

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28696415

Sources:
PharmGKB
DULOXETINE ANO2

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288

Sources:
PharmGKB
DULOXETINE TREML4

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29407288

Sources:
PharmGKB
DULOXETINE NCAM1

Interaction Score: 2.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28696415

Sources:
PharmGKB
DULOXETINE SLC6A2

Interaction Score: 1.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Cymbalta

Novel drug target Established target

PMIDs:
16199241 12481192 16650830 18408530 2784100 14744476 15316838 16139169 15184278 17335951 11752352 15892657 20432324 19480470 9669506

Sources:
TdgClinicalTrial TEND
DULOXETINE SLC6A4

Interaction Score: 1.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Cymbalta

Novel drug target Established target

PMIDs:
16199241 12481192 16650830 18408530 15695064 16032412 2784100 14744476 15316838 17335951 15892657 20432324 19480470 9669506

Sources:
TdgClinicalTrial TEND
DULOXETINE DRD3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22249355

Sources:
PharmGKB
DULOXETINE GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DULOXETINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA

TEND: DULOXETINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class antidepressive agents

Year of Approval 2004

Publications:
TdgClinicalTrial: DULOXETINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: duloxetine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Maciukiewicz M et al., 2018, GWAS-based machine learning approach to predict duloxetine response in major depressive disorder., J Psychiatr Res

Maciukiewicz M et al., 2018, Genome-wide association studies of placebo and duloxetine response in major depressive disorder., Pharmacogenomics J

Perlis RH et al., 2013, Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder., Pharmacogenomics J

DTC: DULOXETINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1175 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Duloxetine
- Version: 2020.06.01
Alternate Names:

D01AXB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1175
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Duloxetine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	Cymbalta
Novel drug target	Established target

Trial Name	Cymbalta
Novel drug target	Established target

DULOXETINE Drug Record

DULOXETINE chembl:CHEMBL1175 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288 28696415

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28696415

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29407288

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28696415

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Cymbalta Novel drug target Established target

PMIDs: 16199241 12481192 16650830 18408530 2784100 14744476 15316838 16139169 15184278 17335951 11752352 15892657 20432324 19480470 9669506

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Cymbalta Novel drug target Established target

PMIDs: 16199241 12481192 16650830 18408530 15695064 16032412 2784100 14744476 15316838 17335951 15892657 20432324 19480470 9669506

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22249355

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

TEND: DULOXETINE

Alternate Names:

Drug Info: Drug Class antidepressive agents Year of Approval 2004

Publications:

TdgClinicalTrial: DULOXETINE

Alternate Names:

Drug Info: Drug Indications antidepressant Drug Class Small Molecule FDA Approval approved

Interaction Types & Directionality:

n/a

PMIDs:
29407288 28696415

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29407288

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29407288

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29407288

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29407288

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29407288

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29407288

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29407288

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28696415

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29407288

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29407288

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28696415

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Cymbalta

Novel drug target Established target

PMIDs:
16199241 12481192 16650830 18408530 2784100 14744476 15316838 16139169 15184278 17335951 11752352 15892657 20432324 19480470 9669506

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Cymbalta

Novel drug target Established target

PMIDs:
16199241 12481192 16650830 18408530 15695064 16032412 2784100 14744476 15316838 17335951 15892657 20432324 19480470 9669506

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
22249355

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Drug Info:

Drug Class antidepressive agents

Year of Approval 2004

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1175 ChEMBL Drug ID

Alternate Names:

D01AXB TTD Drug ID