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ELTROMBOPAG Drug Record

  • Summary
  • Interactions
  • Claims
  • ELTROMBOPAG chembl:CHEMBL461101 Approved

    Alternate Names:

    REVOLADE
    ELTROMBOPAG
    SB497115
    SB-497115-GR
    ETB115
    3'-{(2Z)-2-[1-(3,4-DIMETHYLPHENYL)-3-METHYL-5-OXO-1,5-DIHYDRO-4H-PYRAZOL-4-YLIDENE]HYDRAZINO}-2'-HYDROXYBIPHENYL-3-CARBOXYLIC ACID
    AMG531
    pubchem.compound:135449332
    chemidplus:496775-61-2
    rxcui:711942
    chembl:CHEMBL461101
    drugbank:06210

    Drug Info:

    FDA Approval approved
    Drug Class Small molecule
    Drug Indications thrombopoietic
    Year of Approval 2008
    Drug Class hematopoiesis stimulating agent
    (3 More Sources)

    Publications:

    Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
    Kuter, 2009, Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia., Annu. Rev. Med.
  • ELTROMBOPAG   MPL

    Interaction Score: 3.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Promacta
    Novel drug target Established target

    PMIDs:
    19642221


    Sources:
    TdgClinicalTrial TEND TTD

  • ELTROMBOPAG   F5

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • ELTROMBOPAG   SLC22A1

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • ELTROMBOPAG   SLCO2B1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • ELTROMBOPAG   SLCO1B3

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • ELTROMBOPAG   SERPINC1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • ELTROMBOPAG   SLCO1B1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • TEND: ELTROMBOPAG

    • Version: 01-August-2011

    Alternate Names:
    ELTROMBOPAG Primary Drug Name

    Drug Info:
    Drug Class hematopoiesis stimulating agent
    Year of Approval 2008

    Publications:

  • TdgClinicalTrial: ELTROMBOPAG

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications thrombopoietic
    Drug Class Small molecule
    FDA Approval approved

    Publications:

  • DTC: ELTROMBOPAG

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL461101 ChEMBL Drug ID

    Drug Info:

    Publications:
    Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos

  • TTD: Eltrombopag

    • Version: 2020.06.01

    Alternate Names:
    D00PEH TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL461101

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Eltrombopag

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: eltrombopag

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21