DGIdb - ELTROMBOPAG Drug Record

ELTROMBOPAG chembl:CHEMBL461101 Approved

Alternate Names:

REVOLADE
ELTROMBOPAG
SB497115
SB-497115-GR
ETB115
3'-{(2Z)-2-[1-(3,4-DIMETHYLPHENYL)-3-METHYL-5-OXO-1,5-DIHYDRO-4H-PYRAZOL-4-YLIDENE]HYDRAZINO}-2'-HYDROXYBIPHENYL-3-CARBOXYLIC ACID
AMG531
pubchem.compound:135449332
chemidplus:496775-61-2
rxcui:711942
chembl:CHEMBL461101
drugbank:06210

Drug Info:

FDA Approval	approved
Drug Class	Small molecule
Drug Indications	thrombopoietic
Year of Approval	2008
Drug Class	hematopoiesis stimulating agent

(3 More Sources)

Publications:

Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
Kuter, 2009, Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia., Annu. Rev. Med.

ELTROMBOPAG MPL

Interaction Score: 3.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Promacta

Novel drug target Established target

PMIDs:
19642221

Sources:
TdgClinicalTrial TEND TTD
ELTROMBOPAG F5

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
ELTROMBOPAG SLC22A1

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC
ELTROMBOPAG SLCO2B1

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC
ELTROMBOPAG SLCO1B3

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC
ELTROMBOPAG SERPINC1

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
ELTROMBOPAG SLCO1B1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC

TEND: ELTROMBOPAG
- Version: 01-August-2011
Alternate Names:

ELTROMBOPAG Primary Drug Name

Drug Info:

Drug Class hematopoiesis stimulating agent

Year of Approval 2008

Publications:
TdgClinicalTrial: ELTROMBOPAG
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications thrombopoietic

Drug Class Small molecule

FDA Approval approved

Publications:
DTC: ELTROMBOPAG
- Version: 02-September-2020
Alternate Names:

CHEMBL461101 ChEMBL Drug ID

Drug Info:

Publications:

Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
TTD: Eltrombopag
- Version: 2020.06.01
Alternate Names:

D00PEH TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL461101
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Eltrombopag
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
PharmGKB: eltrombopag
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	Promacta
Novel drug target	Established target

ELTROMBOPAG Drug Record

ELTROMBOPAG chembl:CHEMBL461101 Approved

Alternate Names:

Drug Info:

Publications:

ELTROMBOPAG MPL

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Promacta Novel drug target Established target

PMIDs: 19642221

Sources: TdgClinicalTrial TEND TTD

ELTROMBOPAG F5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

ELTROMBOPAG SLC22A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

ELTROMBOPAG SLCO2B1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

ELTROMBOPAG SLCO1B3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

ELTROMBOPAG SERPINC1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

ELTROMBOPAG SLCO1B1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

TEND: ELTROMBOPAG

Alternate Names: ELTROMBOPAG Primary Drug Name

Drug Info: Drug Class hematopoiesis stimulating agent Year of Approval 2008

Publications:

TdgClinicalTrial: ELTROMBOPAG

Alternate Names:

Drug Info: Drug Indications thrombopoietic Drug Class Small molecule FDA Approval approved

Publications:

DTC: ELTROMBOPAG

Alternate Names: CHEMBL461101 ChEMBL Drug ID

Drug Info:

Publications: Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos

TTD: Eltrombopag

Alternate Names: D00PEH TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL461101

Alternate Names:

Drug Info:

Publications:

FDA: Eltrombopag

Alternate Names:

Drug Info:

Publications:

PharmGKB: eltrombopag

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Promacta

Novel drug target Established target

PMIDs:
19642221

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Alternate Names:

ELTROMBOPAG Primary Drug Name

Drug Info:

Drug Class hematopoiesis stimulating agent

Year of Approval 2008

Drug Info:

Drug Indications thrombopoietic

Drug Class Small molecule

FDA Approval approved

Alternate Names:

CHEMBL461101 ChEMBL Drug ID

Publications:

Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos

Alternate Names:

D00PEH TTD Drug ID