DGIdb - ENALAPRIL Drug Record

ENALAPRIL chembl:CHEMBL578 Approved

Alternate Names:

ENALAPRIL
VASERETIC
LEXXEL
VASOTEC
C09AA02
(S)-1-(N-(1-(ETHOXYCARBONYL)-3-PHENYLPROPYL)-L-ALANYL)-L-PROLINE
EPL753
ENALAPRILUM
1-(N-((S)-1-CARBOXY-3-PHENYLPROPYL)-L-ALANYL)-L-PROLINE 1'-ETHYL ESTER
(S)-1-{(S)-2-[1-((S)-ETHOXYCARBONYL)-3-PHENYL-PROPYLAMINO]-PROPIONYL}-PYRROLIDINE-2-CARBOXYLIC ACID
ENALADEX®
ENALAPRILA
ANALAPRIL
VASOTEC®
chembl:CHEMBL578
chemidplus:75847-73-3
rxcui:3827
pubchem.compound:5388962
drugbank:00584

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Drug Class	antihypertensive agents
Year of Approval	1985

(3 More Sources)

Publications:

Wang et al., 2006, Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system., J. Mol. Cell. Cardiol.
Wang et al., 2008, [Effect of enalapil on renal interstitial fibrosis in rats with unilateral ureteral obstruction]., Zhong Nan Da Xue Xue Bao Yi Xue Ban
Gardiner et al., 2005, Hemodynamic effects of phosphodiesterase 5 and angiotensin-converting enzyme inhibition alone or in combination in conscious SHR., J. Pharmacol. Exp. Ther.
de Cavanagh et al., 2000, Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Liu L et al., 2006, Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers., J Pharmacol Exp Ther
Haas M et al., 1998, Angiotensin-converting enzyme gene polymorphism determines the antiproteinuric and systemic hemodynamic effect of enalapril in patients with proteinuric renal disease. Austrian Study Group of the Effects of Enalapril Treatment in Proteinuric Renal Disease., Kidney Blood Press Res
Sasaki M et al., 1996, Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies., J Hypertens
van Essen GG et al., 1996, Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy., Lancet
Pérez-Castrillón JL et al., 2003, Effect of quinapril, quinapril-hydrochlorothiazide, and enalapril on the bone mass of hypertensive subjects: relationship with angiotensin converting enzyme polymorphisms., Am J Hypertens
Prasad A et al., 2000, Insertion-deletion polymorphism of the ACE gene modulates reversibility of endothelial dysfunction with ACE inhibition., Circulation
Liu et al., 2006, Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice., J. Cardiovasc. Pharmacol.
Andújar-Sánchez et al., 2007, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method., FEBS Lett.
Natesh et al., 2004, Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme., Biochemistry
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Luo JQ et al., 2014, Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment., Pharmacogenomics
Tarkiainen EK et al., 2015, Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril., Br J Clin Pharmacol
Silva PS et al., 2013, eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril., Eur J Clin Pharmacol
Mukae S et al., 2002, Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough., J Hum Hypertens
Okuda et al., 2002, Analyses of differential gene expression in genetic hypertensive rats by microarray., Hypertens. Res.
Esposito et al., 2000, Implication of tissue transglutaminase and desmoplakin in cell adhesion mechanism in human epidermis., Mol. Cell. Biochem.
Iaccarino G et al., 2006, Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension., Clin Pharmacol Ther
Ziori et al., The effects of enalapril on p53 expression in left ventricular cardiomyocytes after aortic stenosis., In Vivo
Shankar et al., 2001, Involvement of nitric oxide in the antiaggregatory effect of enalapril., Methods Find Exp Clin Pharmacol
Costa et al., 2006, Enalapril reduces the expression of nuclear factor-kappaB and c-Jun N-terminal kinase in the renal cortices of five-sixths-nephrectomized rats., Am. J. Nephrol.
Niimi et al., 2002, Suppression of endotoxin-induced renal tumor necrosis factor-alpha and interleukin-6 mRNA by renin-angiotensin system inhibitors., Jpn. J. Pharmacol.
Oliveira-Paula GH et al., 2015, Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril., Eur J Clin Pharmacol

ENALAPRIL DSP

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10839195

Sources:
NCI
ENALAPRIL BDKRB2

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22706620 12522467

Sources:
PharmGKB
ENALAPRIL ACE

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

PMIDs:
9661139 8986921 8538349 12799093 10880412 16424790 17618628 15236580 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD
ENALAPRIL CES1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25919042

Sources:
PharmGKB
ENALAPRIL AGT

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11928713

Sources:
NCI
ENALAPRIL GSR

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10712274

Sources:
NCI
ENALAPRIL NR3C2

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24059494

Sources:
PharmGKB
ENALAPRIL PDE5A

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15452190

Sources:
NCI
ENALAPRIL CCN2

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18812665

Sources:
NCI
ENALAPRIL NOS3

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22706620

Sources:
PharmGKB
ENALAPRIL DPP4

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16678199

Sources:
NCI
ENALAPRIL HSPA4

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12047041

Sources:
NCI
ENALAPRIL VEGFA

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26002049

Sources:
PharmGKB
ENALAPRIL NOS1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11712645

Sources:
NCI
ENALAPRIL MAPK8

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16772709

Sources:
NCI
ENALAPRIL SLCO1B1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16627748

Sources:
PharmGKB
ENALAPRIL ADRB2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17178264

Sources:
PharmGKB
ENALAPRIL APEX1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENALAPRIL TP53

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16900775

Sources:
NCI
ENALAPRIL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

TEND: ENALAPRIL
- Version: 01-August-2011
Alternate Names:

ENALAPRIL Primary Drug Name

Drug Info:

Year of Approval 1985

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: ENALAPRIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: ENALAPRIL

Version: 14-September-2017

Alternate Names:

C468 NCI drug code

Drug Info:

Publications:

de Cavanagh et al., 2000, Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues., Am. J. Physiol. Regul. Integr. Comp. Physiol.

Wang et al., 2006, Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system., J. Mol. Cell. Cardiol.

Niimi et al., 2002, Suppression of endotoxin-induced renal tumor necrosis factor-alpha and interleukin-6 mRNA by renin-angiotensin system inhibitors., Jpn. J. Pharmacol.

PharmGKB: enalapril

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Iaccarino G et al., 2006, Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension., Clin Pharmacol Ther

Silva PS et al., 2013, eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril., Eur J Clin Pharmacol

TTD: Enalapril
- Version: 2020.06.01
Alternate Names:

D00SEB TTD Drug ID

Drug Info:

Publications:
DTC: ENALAPRIL
- Version: 02-September-2020
Alternate Names:

CHEMBL578 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL578
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	enalapril + felodipine,Lexxel
Novel drug target	Established target

ENALAPRIL Drug Record

ENALAPRIL chembl:CHEMBL578 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10839195

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22706620 12522467

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name enalapril + felodipine,Lexxel Novel drug target Established target

PMIDs: 9661139 8986921 8538349 12799093 10880412 16424790 17618628 15236580 11752352

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25919042

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11928713

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10712274

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24059494

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15452190

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18812665

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22706620

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16678199

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12047041

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26002049

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11712645

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16772709

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16627748

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17178264

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16900775

Interaction Types & Directionality:

n/a

PMIDs:
10839195

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22706620 12522467

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

PMIDs:
9661139 8986921 8538349 12799093 10880412 16424790 17618628 15236580 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
25919042

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11928713

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10712274

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24059494

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15452190

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18812665

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22706620

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16678199

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12047041

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26002049

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11712645

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16772709

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16627748

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17178264

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16900775

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

ENALAPRIL Primary Drug Name

Drug Info:

Year of Approval 1985

Drug Class antihypertensive agents

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C468 NCI drug code

Alternate Names:

D00SEB TTD Drug ID

Alternate Names:

CHEMBL578 ChEMBL Drug ID