DGIdb - EPHEDRINE Drug Record

EPHEDRINE chembl:CHEMBL211456 Approved

Alternate Names:

EPHEDRINE
NSC-8971
NSC-170951
L-EPHEDRINE
L-ERYTHRO-2-(METHYLAMINO)-1-PHENYLPROPAN-1-OL
(-)-EPHEDRINE
(1R,2S)-1-PHENYL-1-HYDROXY-2-METHYLAMINOPROPANE
L(−)-EPHEDRINE
L(-)-EPHEDRINE
drugbank:01364
chemidplus:299-42-3
pubchem.compound:9294
chembl:CHEMBL211456
rxcui:3966

Drug Info:

Year of Approval	approved before 1982
Drug Class	central nervous system stimulants
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Central Nervous System Stimulants

(1 More Sources)

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Ma et al., 2007, Pharmacological effects of ephedrine alkaloids on human alpha(1)- and alpha(2)-adrenergic receptor subtypes., J. Pharmacol. Exp. Ther.
Wellman et al., 2003, Noradrenergic modulation of ephedrine-induced hypophagia., Synapse
Statler AK et al., 2020, Ephedrine,
Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
Odekon L et al., 2015, The Effect of β2-Adrenoceptor Genotype on Phenylephrine Dose Administered During Spinal Anesthesia for Cesarean Delivery., Anesth Analg

EPHEDRINE ADRA1A

Interaction Score: 1.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10592235 17405867 12557268 31613441

Sources:
TdgClinicalTrial TEND
EPHEDRINE ADRB2

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
26771271 25730298 31613441

Sources:
PharmGKB
EPHEDRINE DRD2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TdgClinicalTrial: EPHEDRINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Central Nervous System Stimulants

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
TEND: EPHEDRINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class central nervous system stimulants

Year of Approval approved before 1982

Publications:

PharmGKB: ephedrine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg

Odekon L et al., 2015, The Effect of β2-Adrenoceptor Genotype on Phenylephrine Dose Administered During Spinal Anesthesia for Cesarean Delivery., Anesth Analg

TTD: Ephedrine
- Version: 2020.06.01
Alternate Names:

D0LG8E TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL211456
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

EPHEDRINE Drug Record

EPHEDRINE chembl:CHEMBL211456 Approved

Alternate Names:

Drug Info:

Publications:

EPHEDRINE ADRA1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10592235 17405867 12557268 31613441

Sources: TdgClinicalTrial TEND

EPHEDRINE ADRB2

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 26771271 25730298 31613441

Sources: PharmGKB

EPHEDRINE DRD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TdgClinicalTrial: EPHEDRINE

Alternate Names:

Drug Info: Drug Indications Central Nervous System Stimulants Drug Class small molecule FDA Approval Approved before 1982

Publications:

TEND: EPHEDRINE

Alternate Names:

Drug Info: Drug Class central nervous system stimulants Year of Approval approved before 1982

Publications:

PharmGKB: ephedrine

Alternate Names:

Drug Info:

TTD: Ephedrine

Alternate Names: D0LG8E TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL211456

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10592235 17405867 12557268 31613441

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

PMIDs:
26771271 25730298 31613441

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Drug Info:

Drug Indications Central Nervous System Stimulants

Drug Class small molecule

FDA Approval Approved before 1982

Drug Info:

Drug Class central nervous system stimulants

Year of Approval approved before 1982

Alternate Names:

D0LG8E TTD Drug ID