DGIdb - EPIGALOCATECHIN GALLATE Drug Record

EPIGALOCATECHIN GALLATE chembl:CHEMBL297453 Antineoplastic

Alternate Names:

(-)-EPIGALLOCATECHIN GALLATE
EPIGALOCATECHIN GALLATE
(-)-EPIGALLOCATECHIN-3-O-GALLATE
EGCG
EPIGALLOCATECHIN GALLATE，EGCG
EPIGALLOCATECHIN GALLATE
[(2R,3R)-5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-2H-CHROMEN-3-YL] 3,4,5-TRIHYDROXYBENZOATE
drugbank:12116
chemidplus:989-51-5
chembl:CHEMBL297453
pubchem.compound:65064
rxcui:24246

Drug Info:

(0 More Sources)

Publications:

Hsu et al., 2005, Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells., J. Pharmacol. Exp. Ther.
Ishii T et al., 2010, Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin., Bioorg Med Chem
Li et al., 2007, A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1., PLoS ONE
Kweon et al., 2006, Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate., J. Biol. Chem.
Jin et al., 2007, Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Pharmacol. Res.
Cheng XR et al., 2012, The green tea polyphenol (2)-epigallocatechin-3-gallate (EGCG) is not a β-secretase inhibitor., Bioorg Med Chem Lett
Yee et al., 2002, Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells., Mol. Cell. Biochem.
Mirkov et al., 2007, Effects of green tea compounds on irinotecan metabolism., Drug Metab. Dispos.
Takahashi et al., The preventive effect of green tea on the gap junction intercellular communication in renal epithelial cells treated with a renal carcinogen., Anticancer Res.
Larsen CA et al., 2009, Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies., J Med Chem
Nomura et al., 2008, Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells., Biol. Pharm. Bull.
Mocanu MM et al., 2014, Epigallocatechin 3-O-gallate induces 67 kDa laminin receptor-mediated cell death accompanied by downregulation of ErbB proteins and altered lipid raft clustering in mammary and epidermoid carcinoma cells., J Nat Prod
Bigelow et al., 2006, The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells., Oncogene
Amin et al., 2007, SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG., Proc. Natl. Acad. Sci. U.S.A.
Asano et al., 1997, Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia., Life Sci.
Kawai et al., 2005, Epigallocatechin gallate induces apoptosis of monocytes., J. Allergy Clin. Immunol.
Wang D et al., 2012, Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay., Bioorg Med Chem Lett
Hong et al., 2003, Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites., Biochem. Biophys. Res. Commun.

EPIGALOCATECHIN GALLATE COIL

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16046615

Sources:
NCI
EPIGALOCATECHIN GALLATE TP73

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17369354

Sources:
NCI
EPIGALOCATECHIN GALLATE GJA1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15736408

Sources:
NCI
EPIGALOCATECHIN GALLATE HMGB1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17987129

Sources:
NCI
EPIGALOCATECHIN GALLATE HGF

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16449979

Sources:
NCI
EPIGALOCATECHIN GALLATE BACE1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22225636

Sources:
DTC
EPIGALOCATECHIN GALLATE APOB

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11936850

Sources:
NCI
EPIGALOCATECHIN GALLATE DYRK1A

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22154664

Sources:
DTC
EPIGALOCATECHIN GALLATE ALB

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20598557

Sources:
DTC
EPIGALOCATECHIN GALLATE CSF2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9000119 15637567

Sources:
NCI
EPIGALOCATECHIN GALLATE KCNJ11

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17656102

Sources:
NCI
EPIGALOCATECHIN GALLATE SLC2A4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18591783

Sources:
NCI
EPIGALOCATECHIN GALLATE ABCC1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14511674

Sources:
NCI
EPIGALOCATECHIN GALLATE MET

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19839593

Sources:
DTC
EPIGALOCATECHIN GALLATE ERBB2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24456004

Sources:
DTC
EPIGALOCATECHIN GALLATE NFKB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPIGALOCATECHIN GALLATE RECQL

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPIGALOCATECHIN GALLATE APEX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPIGALOCATECHIN GALLATE POLB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPIGALOCATECHIN GALLATE KDM4E

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPIGALOCATECHIN GALLATE BAZ2B

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPIGALOCATECHIN GALLATE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16950787

Sources:
NCI
EPIGALOCATECHIN GALLATE MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPIGALOCATECHIN GALLATE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17108060

Sources:
NCI
EPIGALOCATECHIN GALLATE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPIGALOCATECHIN GALLATE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: EGCG

Version: 14-September-2017

Alternate Names:

C1088 NCI drug code

Drug Info:

Publications:

Jin et al., 2007, Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Pharmacol. Res.

Takahashi et al., The preventive effect of green tea on the gap junction intercellular communication in renal epithelial cells treated with a renal carcinogen., Anticancer Res.

Nomura et al., 2008, Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells., Biol. Pharm. Bull.

DTC: EPIGALOCATECHIN GALLATE

Version: 02-September-2020

Alternate Names:

CHEMBL297453 ChEMBL Drug ID

Drug Info:

Publications:

Wang D et al., 2012, Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay., Bioorg Med Chem Lett

Ishii T et al., 2010, Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin., Bioorg Med Chem

Larsen CA et al., 2009, Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies., J Med Chem

ChemblDrugs: chembl:CHEMBL297453
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

EPIGALOCATECHIN GALLATE Drug Record

EPIGALOCATECHIN GALLATE chembl:CHEMBL297453 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16046615

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17369354

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15736408

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17987129

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16449979

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22225636

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11936850

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22154664

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20598557

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9000119 15637567

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17656102

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18591783

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14511674

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19839593

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24456004

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
16046615

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17369354

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15736408

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17987129

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16449979

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22225636

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11936850

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22154664

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20598557

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9000119 15637567

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17656102

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18591783

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14511674

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19839593

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24456004

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16950787

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17108060

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

C1088 NCI drug code

Alternate Names:

CHEMBL297453 ChEMBL Drug ID