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EPIGALOCATECHIN GALLATE Drug Record

  • Summary
  • Interactions
  • Claims
  • EPIGALOCATECHIN GALLATE chembl:CHEMBL297453 Antineoplastic

    Alternate Names:

    (-)-EPIGALLOCATECHIN GALLATE
    EPIGALOCATECHIN GALLATE
    (-)-EPIGALLOCATECHIN-3-O-GALLATE
    EGCG
    EPIGALLOCATECHIN GALLATE,EGCG
    EPIGALLOCATECHIN GALLATE
    [(2R,3R)-5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-2H-CHROMEN-3-YL] 3,4,5-TRIHYDROXYBENZOATE
    drugbank:12116
    chemidplus:989-51-5
    chembl:CHEMBL297453
    pubchem.compound:65064
    rxcui:24246

    Drug Info:

    (0 More Sources)

    Publications:

    Hsu et al., 2005, Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells., J. Pharmacol. Exp. Ther.
    Ishii T et al., 2010, Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin., Bioorg Med Chem
    Li et al., 2007, A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1., PLoS ONE
    Kweon et al., 2006, Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate., J. Biol. Chem.
    Jin et al., 2007, Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Pharmacol. Res.
    Cheng XR et al., 2012, The green tea polyphenol (2)-epigallocatechin-3-gallate (EGCG) is not a β-secretase inhibitor., Bioorg Med Chem Lett
    Yee et al., 2002, Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells., Mol. Cell. Biochem.
    Mirkov et al., 2007, Effects of green tea compounds on irinotecan metabolism., Drug Metab. Dispos.
    Takahashi et al., The preventive effect of green tea on the gap junction intercellular communication in renal epithelial cells treated with a renal carcinogen., Anticancer Res.
    Larsen CA et al., 2009, Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies., J Med Chem
    Nomura et al., 2008, Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells., Biol. Pharm. Bull.
    Mocanu MM et al., 2014, Epigallocatechin 3-O-gallate induces 67 kDa laminin receptor-mediated cell death accompanied by downregulation of ErbB proteins and altered lipid raft clustering in mammary and epidermoid carcinoma cells., J Nat Prod
    Bigelow et al., 2006, The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells., Oncogene
    Amin et al., 2007, SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG., Proc. Natl. Acad. Sci. U.S.A.
    Asano et al., 1997, Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia., Life Sci.
    Kawai et al., 2005, Epigallocatechin gallate induces apoptosis of monocytes., J. Allergy Clin. Immunol.
    Wang D et al., 2012, Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay., Bioorg Med Chem Lett
    Hong et al., 2003, Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites., Biochem. Biophys. Res. Commun.
  • EPIGALOCATECHIN GALLATE   COIL

    Interaction Score: 4.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16046615


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   TP73

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17369354


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   GJA1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15736408


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   HMGB1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17987129


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   HGF

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16449979


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   BACE1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22225636


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   APOB

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11936850


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   DYRK1A

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22154664


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   ALB

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20598557


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   CSF2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9000119 15637567


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   KCNJ11

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17656102


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   SLC2A4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18591783


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   ABCC1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14511674


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   MET

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19839593


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   ERBB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24456004


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   NFKB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   RECQL

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   APEX1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   POLB

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   KDM4E

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   BAZ2B

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16950787


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   MAPT

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17108060


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPIGALOCATECHIN GALLATE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: EGCG

    • Version: 14-September-2017

    Alternate Names:
    C1088 NCI drug code

    Drug Info:

    Publications:
    Jin et al., 2007, Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Pharmacol. Res.
    Takahashi et al., The preventive effect of green tea on the gap junction intercellular communication in renal epithelial cells treated with a renal carcinogen., Anticancer Res.
    Nomura et al., 2008, Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells., Biol. Pharm. Bull.

  • DTC: EPIGALOCATECHIN GALLATE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL297453 ChEMBL Drug ID

    Drug Info:

    Publications:
    Wang D et al., 2012, Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay., Bioorg Med Chem Lett
    Ishii T et al., 2010, Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin., Bioorg Med Chem
    Larsen CA et al., 2009, Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies., J Med Chem

  • ChemblDrugs: chembl:CHEMBL297453

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21