DGIdb - EPOETIN ALFA Drug Record

EPOETIN ALFA chembl:CHEMBL1201565 Approved

Alternate Names:

EPOETIN ALFA
EPREX
EPO
EPOGEN
PROCRIT
BINOCRIT
ERYTHROPOIETIN PRECURSOR
chemidplus:113427-24-0
chembl:CHEMBL1201565
drugbank:00016
rxcui:105694

Drug Info:

(0 More Sources)

Publications:

Pawlak et al., 2006, Long-term erythropoietin therapy decreases CC-chemokine levels and intima-media thickness in hemodialyzed patients., Am. J. Nephrol.
Kanaan et al., 2006, Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's disease., Brain Res.
Kirito et al., 1997, A distinct function of STAT proteins in erythropoietin signal transduction., J. Biol. Chem.
Ozisik et al., 2006, Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury., Transplant. Proc.
Krosl et al., 1996, Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in Ba/F3 cells via the IL-3 receptor alpha subunit., J. Biol. Chem.
Reems et al., 1997, Differential modulation of adhesion markers with ex vivo expansion of human umbilical CD34+ progenitor cells., Biol. Blood Marrow Transplant.
Park et al., 2006, ERK-mediated production of neurotrophic factors by astrocytes promotes neuronal stem cell differentiation by erythropoietin., Biochem. Biophys. Res. Commun.
Baj et al., 1992, T lymphocyte subsets and NK cell cytotoxicity in chronic hemodialysis patients. The effect of recombinant human erythropoietin (rHu-EPO) treatment., Arch. Immunol. Ther. Exp. (Warsz.)
Xu et al., 2005, Recombinant human erythropoietin pretreatment attenuates myocardial infarct size: a possible mechanism involves heat shock Protein 70 and attenuation of nuclear factor-kappaB., Ann. Clin. Lab. Sci.
Savino et al., 2006, Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis., J. Neuroimmunol.
Liang et al., 1997, Gene expression of LDL receptor, HMG-CoA reductase, and cholesterol-7 alpha-hydroxylase in chronic renal failure., Nephrol. Dial. Transplant.
Imagawa et al., 1997, Negative regulation of the erythropoietin gene expression by the GATA transcription factors., Blood
Imagawa et al., 1996, GATA transcription factors negatively regulate erythropoietin gene expression., Acta Haematol.
Machide et al., 1995, Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain., Oncogene
Hochachka et al., 2003, Fine tuning the HIF-1 'global' O2 sensor for hypobaric hypoxia in Andean high-altitude natives., Bioessays
Wiesener et al., 2002, Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma., Blood
Osada et al., 2002, NADPH-cytochrome P-450 reductase in the plasma membrane modulates the activation of hypoxia-inducible factor 1., J. Biol. Chem.
Carta et al., 2000, Erythropoietin-dependent suppression of the expression of the beta subunits of the interleukin-3 receptor during erythroid differentiation., Blood Cells Mol. Dis.
Jegalian et al., 2002, Differential roles of SOCS family members in EpoR signal transduction., J. Interferon Cytokine Res.
Winteringham et al., 2004, Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation., Oncogene

EPOETIN ALFA CISH

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12396724

Sources:
NCI
EPOETIN ALFA VAV1

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7651724

Sources:
NCI
EPOETIN ALFA CCL4

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17119331

Sources:
NCI
EPOETIN ALFA GATA2

Interaction Score: 2.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9028967 8677751

Sources:
NCI
EPOETIN ALFA STAT5B

Interaction Score: 2.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9195960

Sources:
NCI
EPOETIN ALFA IL3RA

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8910323

Sources:
NCI
EPOETIN ALFA IL1R1

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16337691

Sources:
NCI
EPOETIN ALFA CDKN1B

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15122318

Sources:
NCI
EPOETIN ALFA EPOR

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Erythropoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EPOETIN ALFA TH

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16368081

Sources:
NCI
EPOETIN ALFA NTF3

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16337149

Sources:
NCI
EPOETIN ALFA ITGAL

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9310190

Sources:
NCI
EPOETIN ALFA FCGR3B

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1300984

Sources:
NCI
EPOETIN ALFA LDLR

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9249773

Sources:
NCI
EPOETIN ALFA CA2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11112384

Sources:
NCI
EPOETIN ALFA FCGR3A

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1300984

Sources:
NCI
EPOETIN ALFA HSPA4

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15943180

Sources:
NCI
EPOETIN ALFA BIRC5

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17112829

Sources:
NCI
EPOETIN ALFA HIF1A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12717822 11986208 11971899

Sources:
NCI

NCI: EPO

Version: 14-September-2017

Alternate Names:

C2695 NCI drug code

Drug Info:

Publications:

Ozisik et al., 2006, Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury., Transplant. Proc.

Krosl et al., 1996, Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in Ba/F3 cells via the IL-3 receptor alpha subunit., J. Biol. Chem.

Reems et al., 1997, Differential modulation of adhesion markers with ex vivo expansion of human umbilical CD34+ progenitor cells., Biol. Blood Marrow Transplant.

ChemblDrugs: chembl:CHEMBL1201565
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201565
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Erythropoietin receptor agonist
Direct Interaction	yes

EPOETIN ALFA Drug Record

EPOETIN ALFA chembl:CHEMBL1201565 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12396724

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7651724

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17119331

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9028967 8677751

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9195960

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8910323

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16337691

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15122318

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Erythropoietin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16368081

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16337149

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9310190

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1300984

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9249773

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11112384

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1300984

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15943180

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17112829

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12717822 11986208 11971899

Interaction Types & Directionality:

n/a

PMIDs:
12396724

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7651724

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17119331

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9028967 8677751

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9195960

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8910323

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16337691

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15122318

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Erythropoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16368081

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16337149

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9310190

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1300984

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9249773

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11112384

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1300984

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15943180

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17112829

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12717822 11986208 11971899

Sources:
NCI

Alternate Names:

C2695 NCI drug code