DGIdb - ESTRADIOL Drug Record

ESTRADIOL chembl:CHEMBL135 Approved

Alternate Names:

EVOREL 100
CLIMARA
ESTRADERM MX 100
DERMESTRIL 25
ESTROGEL
GYNERGON
E-CYPIONATE
ELLESTE SOLO MX 80
ADGYN ESTRO
DEPO-ESTRADIOL
VAGIFEM 18
ELESTRIM
AGOFOLLIN
ESTRADERM MX 50
VAGIFEM
FEMSEVEN 50
ESTRING
DIHYDROTHEELIN
ELLESTE SOLO MX 40
VAGIFEM 8
INNOFEM
EVOREL 50
GVNODIOL
IMVEXXY
DERMESTRIL SEPTEM 25
ELESTRIN
MENOREST 75
VIVELLE-DOT
MINIVELLE
GYNOESTRYL
FEMATRIX 80
VIVELLE
ESTRADERM TTS 100
EVOREL 25
GYNOGEN
ESTRADERM TTS 25
ESTRADIOL
WC3011
DERMESTRIL SEPTEM 50
ESTRADERM MX 25
ESTRADERM MX 75
ESTRASORB
DESTRADIOL
ZUMENON
FEMATRIX 40
ESTRADERM TTS 50
MENOREST 37.5
MENORING 50
AQUAGEN
FEMPATCH
ALFATRADIOL
GYNODIOL
CLIMARA PRO
EVAMIST
ESTRADIOL HEMIHYDRATE
EVOREL 75
DERMESTRIL 50
ELLESTE SOLO
ALORA
ESTRADERM
NSC-20293
WC-3011
BEDOL
FEMSEVEN 75
MENOREST 50
DERMESTRIL SEPTEM 75
DIHYDROXYESTRIN
MENOSTAR
OESTRADIOL
ESCLIM
DERMESTRIL 100
DIVIGEL
FEMSEVEN 100
NSC-9895
ESTRACE
PROGYNOVA TS
SANDRENA
COMPUDOSE
ESTRADERM TTS
B-ESTRADIOL
SYNDIOL
17B-ESTRADIOL
DIHYDROFOLLICULAR HORMONE
DELTA-OESTRADIOL
ESTRADIOL-17-BETA
PRIMOFOL
(17BETA)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
ESTROGEN
(1S,10R,11S,14S,15S)-15-METHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-2,4,6-TRIENE-5,14-DIOL
DIOGYN
ESTROCLIM
CLIMADERM
MACRODIOL
OESCLIM
17BETA-OESTRADIOL
OVAHORMON
FEMESTRAL
OVOCYCLIN
17BETA-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
FEMOGEN
EVOREL
OESTROGEL
CIS-ESTRADIOL
AERODIOL
DIHYDROFOLLICULIN
OVASTEVOL
ESTRADOT
DIOGYNETS
17Β-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
ESTROVITE
AQUADIOL
3,17B-DIHYDROXYESTRA-1,3,5(10)-TRIENE
ESTRA-1,3,5(10)-TRIENE-3,17B-DIOL
PROGYNON DH
DIMENFORMON
ESTRADIOLUM
GINOSEDOL
EPIESTRIOL 50
(8R,9S,13S,14S,17S)-13-METHYL-6,7,8,9,11,12,14,15,16,17-DECAHYDROCYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
OVASTEROL
SANDRENA 1
3,17B-ESTRADIOL
BARDIOL
LAMDIOL
(+)-3,17B-ESTRADIOL
PROFOLIOL
PERLATANOL
ESTRALDINE
DIHYDRO-THEELIN
NORDICOL
OESTERGON
3,17-EPIDIHYDROXYESTRATRIENE
OVOCYLIN
D-ESTRADIOL
DERMESTRIL
GELESTRA
OESTROGEN
ESTRING VAGINAL RING
OESTRODIOL
DELTA-ESTRADIOL
ESTRADIOL-17BETA
D-OESTRADIOL
ALTRAD
OESTRA-1,3,5(10)-TRIENE-3,17B-DIOL
BETA-ESTRADIOL
OESTROGLANDOL
17BETA-ESTRADIOL
E2
DIHYDROMENFORMON
17Β-OESTRADIOL
CORPAGEN
17BETA OESTRADIOL
ESTROGEL HBF
13B-METHYL-1,3,5(10)-GONATRIENE-3,17B-OL
(17Β)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
AMNESTROGEN
17B-OESTRADIOL
PROGYNON
FOLLICYCLIN
ESTROCLIM 50
PROFOLIOL B
ENCORE
SYSTEN
MENOREST
chemidplus:50-28-2
pubchem.compound:5757
drugbank:00783
chembl:CHEMBL135

Drug Info:

Drug Class	hormone replacement agents
Year of Approval	approved before 1982
Drug Class	Small molecule
Drug Indications	for treatment of menopausal symptoms
Drug Indications	contraceptive
Drug Indications	hormone replacement
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	hormone replacement,treatment for menopause

(4 More Sources)

Publications:

Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
Lehnes et al., 2007, The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway., Endocrinology
Brama et al., 2007, Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism., Mol. Cell. Endocrinol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Jain D et al., 2010, A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements., Bioorg Med Chem Lett
Maximov PY et al., 2010, Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen., J Med Chem
Chang FR et al., 2005, The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists., J Nat Prod
Bologa et al., 2006, Virtual and biomolecular screening converge on a selective agonist for GPR30., Nat. Chem. Biol.
Renner S et al., 2009, Bioactivity-guided mapping and navigation of chemical space., Nat Chem Biol
Lai A et al., 2015, Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts., J Med Chem
Maximov PY et al., 2014, Influence of the length and positioning of the antiestrogenic side chain of endoxifen and 4-hydroxytamoxifen on gene activation and growth of estrogen receptor positive cancer cells., J Med Chem
Banerjee M et al., 2013, Modulation of xenobiotic receptors by steroids., Molecules
Paterni I et al., 2014, Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential., Steroids
Jiang XR et al., 2013, Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity., J Med Chem
Hixon et al., 1987, Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F-2 alpha secretion in sheep., J. Reprod. Fertil.
Daehlin, 1985, On the effects of oestrogen in the male. Some effects of different oestrogenic substances in rats and men with prostatic carcinoma., Scand J Urol Nephrol Suppl
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Vijayanathan et al., 2007, Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta., Biochem. Cell Biol.
Jiang Y et al., 2013, Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens., FASEB J
Richette et al., 2007, Oestrogens inhibit interleukin 1beta-mediated nitric oxide synthase expression in articular chondrocytes through nuclear factor-kappa B impairment., Ann. Rheum. Dis.
Reinhart et al., 1999, Xeno-oestrogens and phyto-oestrogens induce the synthesis of leukaemia inhibitory factor by human and bovine oviduct cells., Mol. Hum. Reprod.
Schreiber et al., 1980, Dopaminergic modulation of the adenohypophyseal reaction to oestradiol: interaction of perphenazine with the thyroid hormones., Physiol Bohemoslov
Thomas P et al., 2006, Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption., J Steroid Biochem Mol Biol
Prossnitz ER et al., 2007, GPR30: A G protein-coupled receptor for estrogen., Mol Cell Endocrinol
Levenson et al., 1998, Oestradiol regulation of the components of the plasminogen-plasmin system in MDA-MB-231 human breast cancer cells stably expressing the oestrogen receptor., Br. J. Cancer
Harlow et al., 2007, Oestrogen formation and connective tissue growth factor expression in rat granulosa cells., J. Endocrinol.
Kurokawa et al., 2008, Acute effects of oestrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization., J. Physiol. (Lond.)
Gupta et al., 2003, Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus., J. Endocrinol.
Ordóñez et al., 2007, Insulin sensitivity in streptozotocin-induced diabetic rats treated with different doses of 17beta-oestradiol or progesterone., Exp. Physiol.
Robertson et al., 1998, Tamoxifen up-regulates oestrogen receptor-alpha, c-fos and glyceraldehyde 3-phosphate-dehydrogenase mRNAs in ovine endometrium., J. Steroid Biochem. Mol. Biol.
Jönsson et al., 2007, Demonstration of mitochondrial oestrogen receptor beta and oestrogen-induced attenuation of cytochrome c oxidase subunit I expression in human periodontal ligament cells., Arch. Oral Biol.
Wahab et al., 1999, The distribution of endometrial leukocytes and their proliferation markers in trimegestone-treated postmenopausal women compared to the endometrium of the natural cycle: a dose-ranging study., Hum. Reprod.

ESTRADIOL GPER1

Interaction Score: 8.24

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
16520733 17088055 17222505

Sources:
DTC
ESTRADIOL MT-CO1

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17223066

Sources:
NCI
ESTRADIOL PZP

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3868029

Sources:
NCI
ESTRADIOL ESRRA

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23448346

Sources:
DTC
ESTRADIOL LIF

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10508216

Sources:
NCI
ESTRADIOL PTPRC

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10325261

Sources:
NCI
ESTRADIOL PROS1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Estradiol,Progesterone

PMIDs:
None found

Sources:
FDA
ESTRADIOL ESR2

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Bio-E-Gel, estradiol,Elestrin

Novel drug target Established target

Trial Name drospirenone plus estradiol,Angeliq

PMIDs:
16520733 19561619 20659801 17464340 2011412 23882126 24971815

Sources:
DTC TdgClinicalTrial TEND
ESTRADIOL OXTR

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3033233

Sources:
NCI
ESTRADIOL CP

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6446099

Sources:
NCI
ESTRADIOL GAPDH

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9883985

Sources:
NCI
ESTRADIOL PROC

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Estradiol,Progesterone

PMIDs:
None found

Sources:
FDA
ESTRADIOL CCN2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17210741

Sources:
NCI
ESTRADIOL NOS2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17068060

Sources:
NCI
ESTRADIOL ESR1

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Estrogen receptor alpha agonist

Trial Name transdermal estradiol,Divigel

PMIDs:
2011412 17138652 17125913 11752352 20659801 20334368 16038533 16520733 19561619 25879485 24805199 23884115 24971815

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
ESTRADIOL PLAU

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9662256

Sources:
NCI
ESTRADIOL SLC2A4

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17068109

Sources:
NCI
ESTRADIOL SERPINC1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Estradiol,Progesterone

PMIDs:
None found

Sources:
FDA
ESTRADIOL NR3C1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12553866

Sources:
DTC NCI
ESTRADIOL RORC

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESTRADIOL PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESTRADIOL KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18440994

Sources:
NCI
ESTRADIOL RECQL

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESTRADIOL CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ESTRADIOL CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ESTRADIOL CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ESTRADIOL CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ESTRADIOL CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ESTRADIOL AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESTRADIOL EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: ESTRADIOL
- Version: 01-August-2011
Alternate Names:

ESTRADIOL Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class hormone replacement agents

Publications:
TdgClinicalTrial: ESTRADIOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications hormone replacement,treatment for menopause

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: OESTRADIOL

Version: 14-September-2017

Alternate Names:

C478 NCI drug code

Drug Info:

Publications:

Hixon et al., 1987, Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F-2 alpha secretion in sheep., J. Reprod. Fertil.

Reinhart et al., 1999, Xeno-oestrogens and phyto-oestrogens induce the synthesis of leukaemia inhibitory factor by human and bovine oviduct cells., Mol. Hum. Reprod.

Schreiber et al., 1980, Dopaminergic modulation of the adenohypophyseal reaction to oestradiol: interaction of perphenazine with the thyroid hormones., Physiol Bohemoslov

DTC: ESTRADIOL

Version: 02-September-2020

Alternate Names:

CHEMBL135 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Jain D et al., 2010, A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements., Bioorg Med Chem Lett

Bologa et al., 2006, Virtual and biomolecular screening converge on a selective agonist for GPR30., Nat. Chem. Biol.

TTD: Estradiol
- Version: 2020.06.01
Alternate Names:

D08QMX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL135
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL135
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Estradiol
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	Bio-E-Gel, estradiol,Elestrin
Novel drug target	Established target
Trial Name	drospirenone plus estradiol,Angeliq

Direct Interaction	yes
Mechanism of Interaction	Estrogen receptor alpha agonist
Trial Name	transdermal estradiol,Divigel

ESTRADIOL Drug Record

ESTRADIOL chembl:CHEMBL135 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 16520733 17088055 17222505

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17223066

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3868029

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23448346

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10508216

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10325261

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Estradiol,Progesterone

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Bio-E-Gel, estradiol,Elestrin Novel drug target Established target Trial Name drospirenone plus estradiol,Angeliq

PMIDs: 16520733 19561619 20659801 17464340 2011412 23882126 24971815

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3033233

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6446099

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9883985

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Estradiol,Progesterone

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17210741

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17068060

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Estrogen receptor alpha agonist Trial Name transdermal estradiol,Divigel

PMIDs: 2011412 17138652 17125913 11752352 20659801 20334368 16038533 16520733 19561619 25879485 24805199 23884115 24971815

Sources: DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9662256

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17068109

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Estradiol,Progesterone

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12553866

Interaction Types & Directionality:

binder

PMIDs:
16520733 17088055 17222505

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17223066

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3868029

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23448346

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10508216

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10325261

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Estradiol,Progesterone

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Bio-E-Gel, estradiol,Elestrin

Novel drug target Established target

Trial Name drospirenone plus estradiol,Angeliq

PMIDs:
16520733 19561619 20659801 17464340 2011412 23882126 24971815

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
3033233

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6446099

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9883985

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Estradiol,Progesterone

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
17210741

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17068060

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Estrogen receptor alpha agonist

Trial Name transdermal estradiol,Divigel

PMIDs:
2011412 17138652 17125913 11752352 20659801 20334368 16038533 16520733 19561619 25879485 24805199 23884115 24971815

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
9662256

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17068109

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Estradiol,Progesterone

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
12553866

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18440994

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC