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ESTRADIOL BENZOATE Drug Record

  • Summary
  • Interactions
  • Claims
  • ESTRADIOL BENZOATE chembl:CHEMBL282575 Approved

    Alternate Names:

    DIFOLLICULIN
    BETA-ESTRADIOL BENZOATE
    ESTRADIOL BENZOATE
    OESTRADIOL BENZOATE
    ESTRADIOL MONOBENZOATE
    PROGYNON B OLEOSO
    BENZOGYNESTRYL
    BENZTRONE
    BENZESTROFOL
    FOLLIDRIN

    Drug Info:

    Drug Categories ugt1a1 substrates
    Drug Categories steroids
    Drug Categories reproductive control agents
    Drug Categories p-glycoprotein substrates
    Drug Categories oct2 inhibitors
    Drug Categories oct1 inhibitors
    Drug Categories oatp1b1/slco1b1 inhibitors
    Drug Categories hormones, hormone substitutes, and hormone antagonists
    Drug Categories hormones
    Drug Categories hormonal contraceptives for systemic use
    Drug Categories gonadal steroid hormones
    Drug Categories gonadal hormones
    Drug Categories fused-ring compounds
    Drug Categories estrogens
    Drug Categories estrenes
    Drug Categories estranes
    Drug Categories estradiol congeners
    Drug Categories cytochrome p-450 substrates
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 cyp3a7 substrates
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a4 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp2c9 substrates
    Drug Categories cytochrome p-450 cyp2c8 substrates
    Drug Categories cytochrome p-450 cyp2c19 substrates
    Drug Categories cytochrome p-450 cyp1a2 substrates
    Drug Categories cytochrome p-450 cyp1a2 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp1a2 inhibitors
    Drug Categories bcrp/abcg2 inhibitors
    Drug Categories adrenal cortex hormones
    Drug Groups vet_approved
    Drug Groups investigational
    Drug Groups approved
    Drug Type small molecule
    (0 More Sources)

    Publications:

    Xue et al., 2007, Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition., Mol. Endocrinol.
    Paradiso K et al., 2001, The C terminus of the human nicotinic alpha4beta2 receptor forms a binding site required for potentiation by an estrogenic steroid., J Neurosci
    Geistlinger et al., 2004, Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms., Chem. Biol.
    Lehnes et al., 2007, The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway., Endocrinology
    Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Brama et al., 2007, Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism., Mol. Cell. Endocrinol.
    Thomas P et al., 2006, Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption., J Steroid Biochem Mol Biol
    Vijayanathan et al., 2007, Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta., Biochem. Cell Biol.
    Wetzel M et al., 2011, Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors., J Med Chem
    Van Dorst B et al., 2011, The identification of cellular targets of 17β estradiol using a lytic (T7) cDNA phage display approach., Toxicol In Vitro
    Babu S et al., 2012, Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma., Biochem Biophys Res Commun
  • ESTRADIOL BENZOATE   BECN1

    Interaction Score: 4.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21034808


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   MT-ATP6

    Interaction Score: 4.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21034808


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   HSD17B2

    Interaction Score: 4.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21972996


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   GPER1

    Interaction Score: 1.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17088055


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   ESRRG

    Interaction Score: 0.67

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    22935422


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   NCOA2

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15123288


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   CHRNA4

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11517245


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   ESR2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    2011412 17464340


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   ESR1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17138652 2011412 11752352 17125913


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   ATM

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ESTRADIOL BENZOATE   NR1I2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17327420


    Sources:
    DrugBank

  • ESTRADIOL BENZOATE   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ESTRADIOL BENZOATE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB13953

    • Version: 5.1.7

    Alternate Names:
    ESTRADIOL BENZOATE DrugBank Drug Name
    50-50-0 CAS Number
    Climacteron Injection Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Paradiso K et al., 2001, The C terminus of the human nicotinic alpha4beta2 receptor forms a binding site required for potentiation by an estrogenic steroid., J Neurosci
    Lehnes et al., 2007, The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway., Endocrinology
    Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.

  • DTC: ESTRADIOL BENZOATE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL282575 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL282575

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21