DGIdb - ETHOSUXIMIDE Drug Record

ETHOSUXIMIDE chembl:CHEMBL696 Approved

Alternate Names:

SUXINUTIN
EMESIDE
CI-366
PM-671
CN-10395
ETHOSUXIMIDE
NSC-64013
ZARONTIN
3-ETHYL-3-METHYLSUCCINIMIDE
AETHOSUXIMIDE
GAMMA-METHYL-GAMMA-ETHYL-SUCCINIMIDE
3-METHYL-3-ETHYLSUCCINIMIDE
ATYSMAL
(+-)-2-ETHYL-2-METHYLSUCCINIMIDE
3-METHYL-3-ETHYLPYRROLIDINE-2,5-DIONE
THILOPEMAL
2-METHYL-2-ETHYLSUCCINIMIDE
ETOSUXIMIDA
Γ-ETHYL-Γ-METHYL-SUCCINIMIDE
ALPHA-ETHYL-ALPHA-METHYLSUCCINIMIDE
ALPHA-METHYL-ALPHA-ETHYLSUCCINIMIDE
GAMMA-ETHYL-GAMMA-METHYL-SUCCINIMIDE
ZARONTIN®
2-ETHYL-2-METHYLSUCCINIMIDE
ETHOSUXIMIDUM
3-ETHYL-3-METHYL-2,5-PYRROLIDINEDIONE
ETHOSUXIMID
(±)-2-ETHYL-2-METHYLSUCCINIMIDE
drugbank:00593
pubchem.compound:3291
chembl:CHEMBL696
chemidplus:77-67-8
rxcui:4135

Drug Info:

FDA Approval	1960
Drug Class	small molecule
Drug Indications	Anticonvulsants
Drug Class	anticonvulsants
Year of Approval	1960

(2 More Sources)

Publications:

Gomora et al., 2001, Block of cloned human T-type calcium channels by succinimide antiepileptic drugs., Mol. Pharmacol.
Matthews et al., 2001, Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats., Eur. J. Pharmacol.
Wang et al., 2008, Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions., J. Neurosci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure
Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics
Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics
Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet

ETHOSUXIMIDE CACNA1G

Interaction Score: 5.82

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Trial Name -

PMIDs:
11641441 11274992 19005061 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ETHOSUXIMIDE SCN1A

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28753467 25155934 23859570 21747585

Sources:
PharmGKB
ETHOSUXIMIDE CACNA1I

Interaction Score: 0.77

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOSUXIMIDE CACNA1H

Interaction Score: 0.46

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOSUXIMIDE CYP3A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

TEND: ETHOSUXIMIDE
- Version: 01-August-2011
Alternate Names:

ETHOSUXIMIDE Primary Drug Name

Drug Info:

Year of Approval 1960

Drug Class anticonvulsants

Publications:
TdgClinicalTrial: ETHOSUXIMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticonvulsants

Drug Class small molecule

FDA Approval 1960

Publications:

PharmGKB: ethosuximide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics

Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

TTD: Ethosuximide
- Version: 2020.06.01
Alternate Names:

D0Q4XQ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL696
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL696
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Voltage-gated T-type calcium channel blocker
Trial Name	-

blocker (inhibitory)
inhibitor (inhibitory)

ETHOSUXIMIDE Drug Record

ETHOSUXIMIDE chembl:CHEMBL696 Approved

Alternate Names:

Drug Info:

Publications:

ETHOSUXIMIDE CACNA1G

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated T-type calcium channel blocker Trial Name -

PMIDs: 11641441 11274992 19005061 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

ETHOSUXIMIDE SCN1A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28753467 25155934 23859570 21747585

Sources: PharmGKB

ETHOSUXIMIDE CACNA1I

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated T-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ETHOSUXIMIDE CACNA1H

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated T-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ETHOSUXIMIDE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

TEND: ETHOSUXIMIDE

Alternate Names: ETHOSUXIMIDE Primary Drug Name

Drug Info: Year of Approval 1960 Drug Class anticonvulsants

Publications:

TdgClinicalTrial: ETHOSUXIMIDE

Alternate Names:

Drug Info: Drug Indications Anticonvulsants Drug Class small molecule FDA Approval 1960

Publications:

PharmGKB: ethosuximide

Alternate Names:

Drug Info:

TTD: Ethosuximide

Alternate Names: D0Q4XQ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL696

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL696

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Trial Name -

PMIDs:
11641441 11274992 19005061 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
28753467 25155934 23859570 21747585

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

ETHOSUXIMIDE Primary Drug Name

Drug Info:

Year of Approval 1960

Drug Class anticonvulsants

Drug Info:

Drug Indications Anticonvulsants

Drug Class small molecule

FDA Approval 1960

Alternate Names:

D0Q4XQ TTD Drug ID