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ETOMIDATE Drug Record

  • Summary
  • Interactions
  • Claims
  • ETOMIDATE chembl:CHEMBL681 Approved

    Alternate Names:

    ETOMIDATE
    AMIDATE
    (+)-ETHYL 1-(ALPHA-METHYLBENZYL)IMIDAZOLE-5-CARBOXYLATE
    R 16659
    (R)-(+)-1-(ALPHA-METHYLBENZYL)IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
    (+)-ETOMIDATE
    AMIDATE®
    D-ETOMIDATE
    R-(+)-ETHYL 1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLATE
    (+)-ETHYL 1-(Α-METHYLBENZYL)IMIDAZOLE-5-CARBOXYLATE
    ETOMIDATO
    ETOMIDATUM
    3-((R)-1-PHENYL-ETHYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
    (R)-1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
    chembl:CHEMBL681
    rxcui:4177
    chemidplus:33125-97-2
    drugbank:00292
    pubchem.compound:667484

    Drug Info:

    FDA Approval 1982
    Drug Class small molecule
    Drug Indications Anesthetics, Intravenous
    Year of Approval 1982
    Drug Class anesthetics, intravenous
    (2 More Sources)

    Publications:

    Husain SS et al., 2006, Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels., J Med Chem
    Husain SS et al., 2010, p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels., J Med Chem
    Martin et al., 2009, Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade., Anesthesiology
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Desai et al., 2009, Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity., Anesthesiology
    Creagh et al., 2010, Alpha-2B adrenergic receptor mediated hemodynamic profile of etomidate., P R Health Sci J
    Paris et al., 2003, Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate., Anesthesiology
  • ETOMIDATE   GABRA1

    Interaction Score: 0.44

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    16884293 20704351 19809285 17016423 17139284 11752352 19741491


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • ETOMIDATE   ADRA2B

    Interaction Score: 0.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    20496522 14508322


    Sources:
    TdgClinicalTrial TEND

  • ETOMIDATE   GABRG2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    16884293 20704351


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRB2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    16884293 20704351


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRG3

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions TTD

  • ETOMIDATE   GABRQ

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRE

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRD

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRB3

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRG1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRB1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRA4

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRA6

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRA5

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRA3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • ETOMIDATE   GABRA2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    16884293


    Sources:
    DTC ChemblInteractions

  • TEND: ETOMIDATE

    • Version: 01-August-2011

    Alternate Names:
    ETOMIDATE Primary Drug Name

    Drug Info:
    Drug Class anesthetics, intravenous
    Year of Approval 1982

    Publications:

  • TdgClinicalTrial: ETOMIDATE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anesthetics, Intravenous
    Drug Class small molecule
    FDA Approval 1982

    Publications:

  • DTC: ETOMIDATE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL681 ChEMBL Drug ID

    Drug Info:

    Publications:
    Husain SS et al., 2006, Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels., J Med Chem
    Husain SS et al., 2010, p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels., J Med Chem

  • TTD: Etomidate

    • Version: 2020.06.01

    Alternate Names:
    D02YPG TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL681

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL681

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21