DGIdb - ETOMIDATE Drug Record

ETOMIDATE chembl:CHEMBL681 Approved

Alternate Names:

ETOMIDATE
AMIDATE
(+)-ETHYL 1-(ALPHA-METHYLBENZYL)IMIDAZOLE-5-CARBOXYLATE
R 16659
(R)-(+)-1-(ALPHA-METHYLBENZYL)IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
(+)-ETOMIDATE
AMIDATE®
D-ETOMIDATE
R-(+)-ETHYL 1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLATE
(+)-ETHYL 1-(Α-METHYLBENZYL)IMIDAZOLE-5-CARBOXYLATE
ETOMIDATO
ETOMIDATUM
3-((R)-1-PHENYL-ETHYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
(R)-1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
chembl:CHEMBL681
rxcui:4177
chemidplus:33125-97-2
drugbank:00292
pubchem.compound:667484

Drug Info:

FDA Approval	1982
Drug Class	small molecule
Drug Indications	Anesthetics, Intravenous
Year of Approval	1982
Drug Class	anesthetics, intravenous

(2 More Sources)

Publications:

Husain SS et al., 2006, Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels., J Med Chem
Husain SS et al., 2010, p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels., J Med Chem
Martin et al., 2009, Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade., Anesthesiology
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Desai et al., 2009, Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity., Anesthesiology
Creagh et al., 2010, Alpha-2B adrenergic receptor mediated hemodynamic profile of etomidate., P R Health Sci J
Paris et al., 2003, Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate., Anesthesiology

ETOMIDATE GABRA1

Interaction Score: 0.44

Interaction Types & Directionality:

positive modulator (activating)

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293 20704351 19809285 17016423 17139284 11752352 19741491

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND
ETOMIDATE ADRA2B

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20496522 14508322

Sources:
TdgClinicalTrial TEND
ETOMIDATE GABRG2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293 20704351

Sources:
DTC ChemblInteractions
ETOMIDATE GABRB2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293 20704351

Sources:
DTC ChemblInteractions
ETOMIDATE GABRG3

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions TTD
ETOMIDATE GABRQ

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRE

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRP

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRD

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRB3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRG1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRB1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRA4

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRA6

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRA5

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRA3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293

Sources:
DTC ChemblInteractions
ETOMIDATE GABRA2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

TEND: ETOMIDATE
- Version: 01-August-2011
Alternate Names:

ETOMIDATE Primary Drug Name

Drug Info:

Drug Class anesthetics, intravenous

Year of Approval 1982

Publications:
TdgClinicalTrial: ETOMIDATE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anesthetics, Intravenous

Drug Class small molecule

FDA Approval 1982

Publications:

DTC: ETOMIDATE

Version: 02-September-2020

Alternate Names:

CHEMBL681 ChEMBL Drug ID

Drug Info:

Publications:

Husain SS et al., 2006, Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels., J Med Chem

Husain SS et al., 2010, p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels., J Med Chem

TTD: Etomidate
- Version: 2020.06.01
Alternate Names:

D02YPG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL681
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL681
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	GABA-A receptor; anion channel positive modulator

Direct Interaction	yes
Mechanism of Interaction	GABA-A receptor; anion channel positive modulator

positive modulator (activating)
agonist (activating)

ETOMIDATE Drug Record

ETOMIDATE chembl:CHEMBL681 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: positive modulator (activating) agonist (activating)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs: 16884293 20704351 19809285 17016423 17139284 11752352 19741491

Sources: DTC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 20496522 14508322

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs: 16884293 20704351

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs: 16884293 20704351

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs: 16884293

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive modulator Direct Interaction yes

PMIDs: 16884293

Sources: DTC ChemblInteractions

TEND: ETOMIDATE

Alternate Names: ETOMIDATE Primary Drug Name

Drug Info: Drug Class anesthetics, intravenous Year of Approval 1982

Publications:

TdgClinicalTrial: ETOMIDATE

Alternate Names:

Drug Info: Drug Indications Anesthetics, Intravenous Drug Class small molecule FDA Approval 1982

Interaction Types & Directionality:

positive modulator (activating)

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293 20704351 19809285 17016423 17139284 11752352 19741491

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20496522 14508322

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293 20704351

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293 20704351

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive modulator

Direct Interaction yes

PMIDs:
16884293

Sources:
DTC ChemblInteractions

Alternate Names:

ETOMIDATE Primary Drug Name

Drug Info:

Drug Class anesthetics, intravenous

Year of Approval 1982

Drug Info:

Drug Indications Anesthetics, Intravenous

Drug Class small molecule

FDA Approval 1982

Alternate Names:

CHEMBL681 ChEMBL Drug ID

Alternate Names:

D02YPG TTD Drug ID