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ETOPOSIDE PHOSPHATE Drug Record

  • Summary
  • Interactions
  • Claims
  • ETOPOSIDE PHOSPHATE chembl:CHEMBL1200645 Approved

    Alternate Names:

    ETOPOPHOS PRESERVATIVE FREE
    ETOPOPHOS
    BMY-40481
    ETOPOSIDE PHOSPHATE
    VP-16
    VP16

    Drug Info:

    (0 More Sources)

    Publications:

    Vaziri et al., c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis., Anticancer Res.
    Lorico et al., 1995, Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene., Cancer Res.
    Date et al., 2005, Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury., Am. J. Physiol., Cell Physiol.
    Liu et al., 2002, Induction of apoptosis by TPA and VP-16 is through translocation of TR3., World J. Gastroenterol.
    Schepers et al., 2005, HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun., Exp. Hematol.
    Ingles et al., 1991, Reduced binding of TFIID to transcriptionally compromised mutants of VP16., Nature
  • ETOPOSIDE PHOSPHATE   TBP

    Interaction Score: 17.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1646402


    Sources:
    NCI

  • ETOPOSIDE PHOSPHATE   HSPB2

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15911090


    Sources:
    NCI

  • ETOPOSIDE PHOSPHATE   NR4A1

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12046067


    Sources:
    NCI

  • ETOPOSIDE PHOSPHATE   XIAP

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14666661


    Sources:
    NCI

  • ETOPOSIDE PHOSPHATE   SLC2A4

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15496478


    Sources:
    NCI

  • ETOPOSIDE PHOSPHATE   ABCC1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7671247


    Sources:
    NCI

  • ETOPOSIDE PHOSPHATE   TOP2A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NCI: VP-16

    • Version: 14-September-2017

    Alternate Names:
    C491 NCI drug code

    Drug Info:

    Publications:
    Vaziri et al., c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis., Anticancer Res.
    Schepers et al., 2005, HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun., Exp. Hematol.
    Liu et al., 2002, Induction of apoptosis by TPA and VP-16 is through translocation of TR3., World J. Gastroenterol.

  • ChemblDrugs: chembl:CHEMBL1200645

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1200645

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21