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ETRETINATE Drug Record

  • Summary
  • Interactions
  • Claims
  • ETRETINATE chembl:CHEMBL464

    Alternate Names:

    ETRETINATE
    RO-109359
    TEGISON
    TIGASON
    TEGISON®
    ETHYL ALL-TRANS-9-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-3,7-DIMETHYL-2,4,6,8-NONATETRAENOATE
    3,7-DIMETHYL-9-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-2,4,6,8-NONANETETRAENOIC ACID ETHYL ESTER
    ETHYL (ALL-E)-9-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-3,7-DIMETHYL-2,4,6,8-NONATETRAENOATE
    drugbank:00926
    chembl:CHEMBL464
    rxcui:4182
    pubchem.compound:5282375
    chemidplus:54350-48-0

    Drug Info:

    (0 More Sources)

    Publications:

    Billoni et al., 1997, Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth., Acta Derm. Venereol.
    Zitnik et al., 1994, Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts., J. Immunol.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Harnish et al., 1990, Induction of beta-retinoic acid receptor mRNA by teratogenic doses of retinoids in murine fetuses., Differentiation
    Saurat, 1999, Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment., J. Am. Acad. Dermatol.
    Orfanos et al., 1997, Current use and future potential role of retinoids in dermatology., Drugs
  • ETRETINATE   RXRG

    Interaction Score: 4.42

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    9298126 17016423 17139284


    Sources:
    ChemblInteractions

  • ETRETINATE   RXRB

    Interaction Score: 2.94

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    17016423 17139284


    Sources:
    ChemblInteractions

  • ETRETINATE   RARG

    Interaction Score: 2.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    10592235 17016423 17139284


    Sources:
    ChemblInteractions

  • ETRETINATE   RARB

    Interaction Score: 1.89

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    9298126 8301142


    Sources:
    ChemblInteractions

  • ETRETINATE   RARA

    Interaction Score: 1.77

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoid receptor agonist

    PMIDs:
    1965892 10459139 8301142 9074840 9298126


    Sources:
    ChemblInteractions

  • ETRETINATE   RXRA

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    9298126 8301142 9074840


    Sources:
    ChemblInteractions

  • ETRETINATE   GMNN

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DTC: ETRETINATE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL464 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL464

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL464

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21