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FEBUXOSTAT Drug Record

  • Summary
  • Interactions
  • Claims
  • FEBUXOSTAT chembl:CHEMBL1164729 Approved

    Alternate Names:

    FEBUXOSTAT
    TMX-67
    ADENURIC
    ULORIC
    FÉBUXOSTAT
    ADENURIC®
    TEI 6720
    MX-67
    FEBUXOSTATUM
    TMX 67
    ULORIC®
    2-(3-CYANO-4-ISOBUTOXYPHENYL)-4-METHYL- 1,3-THIAZOLE-5-CARBOXYLIC ACID
    TEI-6720
    pubchem.compound:134018
    rxcui:73689
    chembl:CHEMBL1164729
    drugbank:04854
    chemidplus:144060-53-7

    Drug Info:

    Year of Approval 2009
    Drug Class gout suppressants
    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications for treatment of gout
    (3 More Sources)

    Publications:

    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Bruce, 2006, Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout., Ann Pharmacother
    McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics
  • FEBUXOSTAT   AOX1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   XDH

    Interaction Score: 1.96

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Xanthine dehydrogenase inhibitor
    Direct Interaction yes
    Trial Name febuxostat, TMX-67,Uloric, Adenuric, Feburic

    PMIDs:
    17132810 27798726 24915143


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • FEBUXOSTAT   UGT1A7

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A5

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A10

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A8

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A6

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A3

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A4

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A9

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • FEBUXOSTAT   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: FEBUXOSTAT

    • Version: 01-August-2011

    Alternate Names:
    FEBUXOSTAT Primary Drug Name

    Drug Info:
    Drug Class gout suppressants
    Year of Approval 2009

    Publications:

  • TdgClinicalTrial: FEBUXOSTAT

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of gout
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • PharmGKB: febuxostat

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics

  • DTC: FEBUXOSTAT

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1164729 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Febuxostat

    • Version: 2020.06.01

    Alternate Names:
    D0A5SE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1164729

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1164729

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21