DGIdb - FEBUXOSTAT Drug Record

FEBUXOSTAT chembl:CHEMBL1164729 Approved

Alternate Names:

FEBUXOSTAT
TMX-67
ADENURIC
ULORIC
FÉBUXOSTAT
ADENURIC®
TEI 6720
MX-67
FEBUXOSTATUM
TMX 67
ULORIC®
2-(3-CYANO-4-ISOBUTOXYPHENYL)-4-METHYL- 1,3-THIAZOLE-5-CARBOXYLIC ACID
TEI-6720
pubchem.compound:134018
rxcui:73689
chembl:CHEMBL1164729
drugbank:04854
chemidplus:144060-53-7

Drug Info:

Year of Approval	2009
Drug Class	gout suppressants
FDA Approval	not approved
Drug Class	Small molecule
Drug Indications	for treatment of gout

(4 More Sources)

Publications:

Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
Bruce, 2006, Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout., Ann Pharmacother
McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics

FEBUXOSTAT XDH

Interaction Score: 2.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Direct Interaction yes

Details of the Assay for Interaction Inhibition of baculovirus expressed C-terminally FLAG-tagged human xanthine oxidase (aa 1-1333).

PMIDs:
17132810 27798726 24915143

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD

FEBUXOSTAT AOX1

Interaction Score: 2.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT UGT1A7

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT UGT1A5

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT UGT1A10

Interaction Score: 1.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT UGT1A8

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT UGT1A6

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT UGT1A3

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT UGT1A4

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT UGT1A9

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT UGT1A1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
FEBUXOSTAT AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: FEBUXOSTAT
- Version: 01-August-2011
Alternate Names:

FEBUXOSTAT Primary Drug Name

Drug Info:

Drug Class gout suppressants

Year of Approval 2009

Publications:
TdgClinicalTrial: FEBUXOSTAT
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of gout

Drug Class Small molecule

FDA Approval not approved

Publications:

PharmGKB: febuxostat

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics

DTC: FEBUXOSTAT
- Version: 02-September-2020
Alternate Names:

CHEMBL1164729 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Febuxostat
- Version: 2020.06.01
Alternate Names:

D0A5SE TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178103423
- Version: 29-September-2020
Alternate Names:

FEBUXOSTAT GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1164729
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1164729
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Xanthine dehydrogenase inhibitor
Direct Interaction	yes
Details of the Assay for Interaction	Inhibition of baculovirus expressed C-terminally FLAG-tagged human xanthine oxidase (aa 1-1333).

FEBUXOSTAT Drug Record

FEBUXOSTAT chembl:CHEMBL1164729 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Xanthine dehydrogenase inhibitor Direct Interaction yes Details of the Assay for Interaction Inhibition of baculovirus expressed C-terminally FLAG-tagged human xanthine oxidase (aa 1-1333).

PMIDs: 17132810 27798726 24915143

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: FEBUXOSTAT

Alternate Names: FEBUXOSTAT Primary Drug Name

Drug Info: Drug Class gout suppressants Year of Approval 2009

Publications:

TdgClinicalTrial: FEBUXOSTAT

Alternate Names:

Drug Info: Drug Indications for treatment of gout Drug Class Small molecule FDA Approval not approved

Publications:

PharmGKB: febuxostat

Alternate Names:

Drug Info:

Publications: Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics

DTC: FEBUXOSTAT

Alternate Names: CHEMBL1164729 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Febuxostat

Alternate Names: D0A5SE TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178103423

Alternate Names: FEBUXOSTAT GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1164729

Alternate Names:

Drug Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Direct Interaction yes

Details of the Assay for Interaction Inhibition of baculovirus expressed C-terminally FLAG-tagged human xanthine oxidase (aa 1-1333).

PMIDs:
17132810 27798726 24915143

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

FEBUXOSTAT Primary Drug Name

Drug Info:

Drug Class gout suppressants

Year of Approval 2009

Drug Info:

Drug Indications for treatment of gout

Drug Class Small molecule

FDA Approval not approved

Publications:

Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

CHEMBL1164729 ChEMBL Drug ID

Alternate Names:

D0A5SE TTD Drug ID

Alternate Names:

FEBUXOSTAT GuideToPharmacology Ligand Name