DGIdb - FILGRASTIM Drug Record

FILGRASTIM chembl:CHEMBL1201567 Approved

Alternate Names:

XM-02
ACCOFIL
TX01
FILGRASTIM
NEUPOGEN 30
TX-01
NEUPOGEN
KRN-8601
NEUPOGEN 48
TBO-FILGRASTIM
NIVESTIM
ZARZIO
R-METHUG-CSF
XM02
MBRI-9901
FILGRASTIM-SNDZ
G-CSF
GRANULOCYTE COLONY STIMULATING FACTOR
chemidplus:121181-53-1
chembl:CHEMBL1201567
rxcui:68442
drugbank:00099

Drug Info:

Year of Approval	1991
Drug Class	antineutropenic agents
FDA Approval	approved
Drug Class	recombinant protein
Drug Indications	for treatment of neutropenia

(5 More Sources)

Publications:

Zhuang et al., 2005, Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1., J. Leukoc. Biol.
Cao et al., 2005, [The response of bone marrow hematopoietic cells to G-CSF in paroxysmal nocturnal hemoglobinuria patients]., Zhonghua Xue Ye Xue Za Zhi
Erkeland et al., 2007, Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling., Oncogene
Link et al., 2007, Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia., Blood
Ward, 2007, The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease., Front. Biosci.
Yagyu et al., 2006, Enhanced spontaneous metastasis in bikunin-deficient mice., Int. J. Cancer
Sugimoto et al., 2001, Granulocyte colony-stimulating factor (G-CSF)-mediated signaling regulates type IV collagenase activity in head and neck cancer cells., Int. J. Cancer
Hurley et al., 2006, Docetaxel, cisplatin, and trastuzumab as primary systemic therapy for human epidermal growth factor receptor 2-positive locally advanced breast cancer., J. Clin. Oncol.
Calvo et al., 2001, Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia., Proc. Natl. Acad. Sci. U.S.A.
Sloand, 2005, Soluble urokinase activator receptor (suPAR) in stem cell mobilization., Blood
Watanabe et al., 2003, Effect of granulocyte colony-stimulating factor on bone metabolism during peripheral blood stem cell mobilization., Int. J. Hematol.
Takahashi et al., 1991, Role of colony-stimulating factors in osteoclast development., J. Bone Miner. Res.
Bailly et al., 1995, Effect of 5637-conditioned medium and recombinant cytokines on P-glycoprotein expression in a human GM-CSF-dependent leukemic myeloid cell line., Leukemia
Hunter et al., 1998, Phosphatidylinositol 3'-kinase and SH2-containing inositol phosphatase (SHIP) are recruited by distinct positive and negative growth-regulatory domains in the granulocyte colony-stimulating factor receptor., J. Immunol.

FILGRASTIM HOXA9

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11687616

Sources:
NCI
FILGRASTIM CSF3R

Interaction Score: 7.95

Interaction Types & Directionality:

agonist (activating)

stimulator (activating)

Interaction Info:

Trial Name topical filgrastim, Nupen

Novel drug target Established target

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

PMIDs:
16033816 15949269 17001306 17494858 17127322

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
FILGRASTIM PLAUR

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15747404

Sources:
NCI
FILGRASTIM ACP5

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1724107

Sources:
NCI
FILGRASTIM BTF3P11

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12568303

Sources:
NCI
FILGRASTIM MMP2

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11391619

Sources:
NCI
FILGRASTIM PLAU

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16331631

Sources:
NCI
FILGRASTIM PIK3CG

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9590246

Sources:
NCI
FILGRASTIM ERBB2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16549824

Sources:
NCI
FILGRASTIM ABCB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7564516

Sources:
NCI

TEND: FILGRASTIM
- Version: 01-August-2011
Alternate Names:

FILGRASTIM Primary Drug Name

Drug Info:

Drug Class antineutropenic agents

Year of Approval 1991

Publications:
TdgClinicalTrial: FILGRASTIM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of neutropenia

Drug Class recombinant protein

FDA Approval approved

Publications:

NCI: G-CSF

Version: 14-September-2017

Alternate Names:

C1287 NCI drug code

Drug Info:

Publications:

Yagyu et al., 2006, Enhanced spontaneous metastasis in bikunin-deficient mice., Int. J. Cancer

Takahashi et al., 1991, Role of colony-stimulating factors in osteoclast development., J. Bone Miner. Res.

Bailly et al., 1995, Effect of 5637-conditioned medium and recombinant cytokines on P-glycoprotein expression in a human GM-CSF-dependent leukemic myeloid cell line., Leukemia

NCI: FILGRASTIM
- Version: 14-September-2017
Alternate Names:

C1474 NCI drug code

Drug Info:

Publications:

Hurley et al., 2006, Docetaxel, cisplatin, and trastuzumab as primary systemic therapy for human epidermal growth factor receptor 2-positive locally advanced breast cancer., J. Clin. Oncol.
TTD: Tbo-Filgrastim
- Version: 2020.06.01
Alternate Names:

D09WDK TTD Drug ID

Drug Info:

Publications:
TTD: Filgrastim-SNDZ
- Version: 2020.06.01
Alternate Names:

D07WKC TTD Drug ID

Drug Info:

Publications:
TTD: Filgrastim
- Version: 2020.06.01
Alternate Names:

D02VVS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201567
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201567
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	topical filgrastim, Nupen
Novel drug target	Established target
Mechanism of Interaction	Granulocyte colony stimulating factor receptor agonist

agonist (activating)
stimulator (activating)

FILGRASTIM Drug Record

FILGRASTIM chembl:CHEMBL1201567 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11687616

Sources: NCI

Interaction Types & Directionality: agonist (activating) stimulator (activating)

Interaction Info: Trial Name topical filgrastim, Nupen Novel drug target Established target Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

PMIDs: 16033816 15949269 17001306 17494858 17127322

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15747404

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1724107

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12568303

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11391619

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16331631

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9590246

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16549824

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7564516

Sources: NCI

TEND: FILGRASTIM

Alternate Names: FILGRASTIM Primary Drug Name

Drug Info: Drug Class antineutropenic agents Year of Approval 1991

Publications:

TdgClinicalTrial: FILGRASTIM

Alternate Names:

Drug Info: Drug Indications for treatment of neutropenia Drug Class recombinant protein FDA Approval approved

Publications:

NCI: G-CSF

Alternate Names: C1287 NCI drug code

Drug Info:

NCI: FILGRASTIM

Alternate Names: C1474 NCI drug code

Drug Info:

Publications: Hurley et al., 2006, Docetaxel, cisplatin, and trastuzumab as primary systemic therapy for human epidermal growth factor receptor 2-positive locally advanced breast cancer., J. Clin. Oncol.

TTD: Tbo-Filgrastim

Alternate Names: D09WDK TTD Drug ID

Drug Info:

Publications:

TTD: Filgrastim-SNDZ

Alternate Names: D07WKC TTD Drug ID

Drug Info:

Publications:

TTD: Filgrastim

Alternate Names: D02VVS TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201567

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201567

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
11687616

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

stimulator (activating)

Interaction Info:

Trial Name topical filgrastim, Nupen

Novel drug target Established target

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

PMIDs:
16033816 15949269 17001306 17494858 17127322

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
15747404

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1724107

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12568303

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11391619

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16331631

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9590246

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16549824

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7564516

Sources:
NCI

Alternate Names:

FILGRASTIM Primary Drug Name

Drug Info:

Drug Class antineutropenic agents

Year of Approval 1991

Drug Info:

Drug Indications for treatment of neutropenia

Drug Class recombinant protein

FDA Approval approved

Alternate Names:

C1287 NCI drug code

Alternate Names:

C1474 NCI drug code

Publications:

Hurley et al., 2006, Docetaxel, cisplatin, and trastuzumab as primary systemic therapy for human epidermal growth factor receptor 2-positive locally advanced breast cancer., J. Clin. Oncol.

Alternate Names:

D09WDK TTD Drug ID

Alternate Names:

D07WKC TTD Drug ID

Alternate Names:

D02VVS TTD Drug ID