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FLOXACILLIN Drug Record

  • Summary
  • Interactions
  • Claims
  • FLOXACILLIN chembl:CHEMBL222645 Approved

    Alternate Names:

    FLOXACILLIN
    BRL-2039
    STAPHLIPEN
    FLUCLOXACILLIN SODIUM
    GALFLOXIN
    RIMAFLOX
    ZOXIN 500
    STAFOXIL
    FLUCLOXACILLIN
    ZOXIN 250
    FLUCLOMIX-500
    FLUCLOMIX-250
    ABBOFLOX
    FLUCLOXIN
    FLOXAPEN
    LADROPEN
    3-(2-CHLORO-6-FLUOROPHENYL)-5-METHYL-4-ISOXAZOLYLPENICILLIN
    (2S,5R,6R)-6-({[3-(2-CHLORO-6-FLUOROPHENYL)-5-METHYL-1,2-OXAZOL-4-YL]CARBONYL}AMINO)-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID
    FLUCLOXACILLINE
    FLUCLOXACILINA
    FLUCLOXACILLINUM
    pubchem.compound:21319
    drugbank:00301
    rxcui:4448
    chemidplus:5250-39-5
    chembl:CHEMBL222645

    Drug Info:

    (0 More Sources)

    Publications:

    Cirulli ET et al., 2019, A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury., Gastroenterology
    Daly AK et al., 2009, HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin., Nat Genet
    Andrews E et al., 2010, A role for the pregnane X receptor in flucloxacillin-induced liver injury., Hepatology
    Mallal S et al., 2008, HLA-B*5701 screening for hypersensitivity to abacavir., N Engl J Med
    Wuillemin N et al., 2014, T cells infiltrate the liver and kill hepatocytes in HLA-B(∗)57:01-associated floxacillin-induced liver injury., Am J Pathol
    Wuillemin N et al., 2013, HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin., J Immunol
    Phillips EJ et al., 2013, HLA-B*5701 and flucloxacillin associated drug-induced liver disease., AIDS
    Yip VL et al., 2012, HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review., Clin Pharmacol Ther
    Vera JH et al., 2013, The safety of flucloxacillin in HIV-infected patients with positive HLA-B*5701 genotype., AIDS
    Tassaneeyakul W et al., 2009, Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population., Pharmacogenet Genomics
    Locharernkul C et al., 2008, Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population., Epilepsia
  • FLOXACILLIN   ST6GAL1

    Interaction Score: 17.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19483685


    Sources:
    PharmGKB

  • FLOXACILLIN   HLA-B

    Interaction Score: 3.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875 18256392 24731753 23596311 23291545 23132554 23032409 19696695 19483685 18637831


    Sources:
    PharmGKB

  • FLOXACILLIN   HLA-DRA

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875


    Sources:
    PharmGKB

  • FLOXACILLIN   HLA-DQB1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875


    Sources:
    PharmGKB

  • FLOXACILLIN   HLA-C

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875


    Sources:
    PharmGKB

  • FLOXACILLIN   HLA-DRB1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30664875


    Sources:
    PharmGKB

  • FLOXACILLIN   NR1I2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20222094


    Sources:
    PharmGKB

  • PharmGKB: flucloxacillin

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Andrews E et al., 2010, A role for the pregnane X receptor in flucloxacillin-induced liver injury., Hepatology
    Cirulli ET et al., 2019, A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury., Gastroenterology
    Wuillemin N et al., 2013, HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillin., J Immunol

  • TTD: Flucloxacillin

    • Version: 2020.06.01

    Alternate Names:
    D0Q2AT TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL222645

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21