• Interaction Score: 0.25

    Interaction Types & Directionality:
    allosteric modulator
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist

  • Interaction Score: 0.24

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator
    antagonist (inhibitory)

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Details of the Assay for Interaction Affinity measured using α1β3γ2 receptors.
    Specific Action of the Ligand Antagonist

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes
    Specific Binding Site for Interaction benzodiazepine site

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes
    Specific Binding Site for Interaction benzodiazepine site

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Details of the Assay for Interaction Affinity measured using α6β3γ2 receptors.
    Specific Action of the Ligand Partial agonist

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist

    PMIDs:
    None found


  • Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

    • Version: 01-August-2011

    Alternate Names:
    FLUMAZENIL Primary Drug Name

    Drug Info:
    Year of Approval 1991
    Drug Class antidotes, benzodoazepine overdose

    Publications:

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antidotes, Benzodoazepine Overdose
    Drug Class small molecule
    FDA Approval 1991

    Publications:

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL407 ChEMBL Drug ID

    Drug Info:

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    D0D5GD TTD Drug ID

    Drug Info:

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    FLUMAZENIL GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications: