DGIdb - FLUPENTIXOL Drug Record

FLUPENTIXOL chembl:CHEMBL54661

Alternate Names:

LC-44
FLUPENTIXOL
N-7009
FLUPENTHIXOL
ALPHA-FLUPENTHIXOL
CIS FLUPENTHIXOL
drugbank:00875
chembl:CHEMBL54661
chemidplus:53772-82-0
pubchem.compound:5281881

Drug Info:

(0 More Sources)

Publications:

Reimold et al., 2007, Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol., Psychopharmacology (Berl.)
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Cai et al., 1999, Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein., Mol. Pharmacol.
Arnt, 1995, Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine., Eur. J. Pharmacol.
Nilsson et al., 1996, Inverse agonism at dopamine D2 receptors. Haloperidol-induced prolactin release from GH4C1 cells transfected with the human D2 receptor is antagonized by R(-)-n-propylnorapomorphine, raclopride, and phenoxybenzamine., Neuropsychopharmacology
Ogren et al., 1984, Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain., Eur. J. Pharmacol.
Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Huettl et al., 1991, Effects of dopamine receptor agonists and antagonists on catecholamine release in bovine chromaffin cells., J. Pharmacol. Exp. Ther.
Tresadern G et al., 2011, Molecular properties affecting fast dissociation from the D2 receptor., Bioorg Med Chem

FLUPENTIXOL DRD2

Interaction Score: 0.51

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7498321 8797192 6149133 11873706 11752352 1674528 17111172 21421319

Sources:
DTC GuideToPharmacology

FLUPENTIXOL DRD1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Note that this assay uses the cis form of the compound, whereas the approved drug is a racemic mixture of cis and trans molecules.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
17111172 17016423 17139284 10531405

Sources:
DTC GuideToPharmacology

FLUPENTIXOL DRD5

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
FLUPENTIXOL DRD3

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
FLUPENTIXOL CBX1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUPENTIXOL USP1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUPENTIXOL ATXN2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: FLUPENTIXOL
- Version: 02-September-2020
Alternate Names:

CHEMBL54661 ChEMBL Drug ID

Drug Info:

Publications:

Tresadern G et al., 2011, Molecular properties affecting fast dissociation from the D2 receptor., Bioorg Med Chem
GuideToPharmacology: 135650273
- Version: 29-September-2020
Alternate Names:

FLUPENTIXOL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL54661
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

Details of the Assay for Interaction	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

FLUPENTIXOL Drug Record

FLUPENTIXOL chembl:CHEMBL54661

Alternate Names:

Drug Info:

Publications:

FLUPENTIXOL DRD2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 7498321 8797192 6149133 11873706 11752352 1674528 17111172 21421319

Sources: DTC GuideToPharmacology

FLUPENTIXOL DRD1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Details of the Assay for Interaction Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules. Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 17111172 17016423 17139284 10531405

Sources: DTC GuideToPharmacology

FLUPENTIXOL DRD5

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

FLUPENTIXOL DRD3

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: None found

Sources: GuideToPharmacology

FLUPENTIXOL CBX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

FLUPENTIXOL USP1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

FLUPENTIXOL ATXN2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DTC: FLUPENTIXOL

Alternate Names: CHEMBL54661 ChEMBL Drug ID

Drug Info:

Publications: Tresadern G et al., 2011, Molecular properties affecting fast dissociation from the D2 receptor., Bioorg Med Chem

GuideToPharmacology: 135650273

Alternate Names: FLUPENTIXOL GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL54661

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7498321 8797192 6149133 11873706 11752352 1674528 17111172 21421319

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
17111172 17016423 17139284 10531405

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHEMBL54661 ChEMBL Drug ID

Publications:

Tresadern G et al., 2011, Molecular properties affecting fast dissociation from the D2 receptor., Bioorg Med Chem

Alternate Names:

FLUPENTIXOL GuideToPharmacology Ligand Name