• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

FLUTAMIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • FLUTAMIDE chembl:CHEMBL806 ApprovedAntineoplastic

    Alternate Names:

    EULEXIN
    FLUTAMIDE
    DROGENIL
    SCH-13521
    NSC-215876
    CHIMAX
    NFBA
    EULEXIN®
    FLUTAMIDUM
    NIFTOLIDE
    ALPHA,ALPHA,ALPHA-TRIFLUORO-2-METHYL-4'-NITRO-M-PROPIONOTOLUIDIDE
    4'-NITRO-3'-TRIFLUOROMETHYLISOBUTYRANILIDE
    FLUTAMIDA
    NIFTOLID
    FTA
    FLUTAMID
    drugbank:00499
    rxcui:4508
    chembl:CHEMBL806
    pubchem.compound:3397
    chemidplus:13311-84-7

    Drug Info:

    Drug Class antineoplastic agents, hormonal
    Year of Approval 1989
    FDA Approval 1989
    Drug Class small molecule
    Drug Indications Antineoplastic Agents, Hormonal
    (6 More Sources)

    Publications:

    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Zhang et al., 2005, Survivin mediates resistance to antiandrogen therapy in prostate cancer., Oncogene
    Messingham et al., 2001, Testosterone receptor blockade restores cellular immunity in male mice after burn injury., J. Endocrinol.
    Montalvo et al., 2000, Effect of flutamide-induced androgen-receptor blockade on adenylate cyclase activation through G-protein coupled receptors in rat prostate., Cell. Signal.
    Martelli et al., 2000, Evaluation of flutamide genotoxicity in rats and in primary human hepatocytes., Pharmacol. Toxicol.
    Balk, 2002, Androgen receptor as a target in androgen-independent prostate cancer., Urology
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Pazos et al., 2000, Mechanisms of reduced body growth in the pubertal feminized male rat: unbalanced estrogen and androgen action on the somatotropic axis., Pediatr. Res.
    Chang et al., 1999, Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells., Proc. Natl. Acad. Sci. U.S.A.
    Shilling et al., 2000, The non-aromatizable androgen, dihydrotestosterone, induces antiestrogenic responses in the rainbow trout., J. Steroid Biochem. Mol. Biol.
    Robinson et al., 2015, Integrative clinical genomics of advanced prostate cancer., Cell
    Yu et al., 2006, Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1., J. Leukoc. Biol.
    Vinggaard et al., 2002, Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz., Toxicol. Sci.
    Kritzer et al., 2001, Administration of tamoxifen but not flutamide to hormonally intact, adult male rats mimics the effects of short-term gonadectomy on the catecholamine innervation of the cerebral cortex., J. Comp. Neurol.
    Harmsen et al., 2009, Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor., Cancer Chemother. Pharmacol.
    Hsieh et al., 2005, PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage., Am. J. Physiol. Heart Circ. Physiol.
    Pastor-Soler et al., 2002, Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens., Biol. Reprod.
    Fowler et al., 1995, Prostate specific antigen after gonadal androgen withdrawal and deferred flutamide treatment., J. Urol.
    Wang et al., 2005, Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism., Asian J. Androl.
  • FLUTAMIDE   PEBP1

    Interaction Score: 3.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12377983


    Sources:
    NCI

  • FLUTAMIDE   AQP9

    Interaction Score: 1.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12021052


    Sources:
    NCI

  • FLUTAMIDE   VIP

    Interaction Score: 0.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10822172


    Sources:
    NCI

  • FLUTAMIDE   TH

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11223814


    Sources:
    NCI

  • FLUTAMIDE   CDKN1A

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16281084


    Sources:
    NCI

  • FLUTAMIDE   KLK3

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7541862


    Sources:
    NCI

  • FLUTAMIDE   MPO

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16330533


    Sources:
    NCI

  • FLUTAMIDE   IL2RA

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11312147


    Sources:
    NCI

  • FLUTAMIDE   BIRC5

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15735703


    Sources:
    NCI

  • FLUTAMIDE   G6PD

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • FLUTAMIDE   NR1I2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18839173


    Sources:
    PharmGKB

  • FLUTAMIDE   AR

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Androgen Receptor antagonist

    PMIDs:
    10822172 10752671 12231070 11752352 10879806 10500149 11162924 26000489


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND CIViC TTD

  • FLUTAMIDE   RORC

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUTAMIDE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • FLUTAMIDE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528 22931300


    Sources:
    DTC PharmGKB

  • FLUTAMIDE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • FLUTAMIDE   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16055512


    Sources:
    DTC NCI

  • FLUTAMIDE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUTAMIDE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: FLUTAMIDE

    • Version: 01-August-2011

    Alternate Names:
    FLUTAMIDE Primary Drug Name

    Drug Info:
    Year of Approval 1989
    Drug Class antineoplastic agents, hormonal

    Publications:

  • TdgClinicalTrial: FLUTAMIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antineoplastic Agents, Hormonal
    Drug Class small molecule
    FDA Approval 1989

    Publications:

  • NCI: FLUTAMIDE

    • Version: 14-September-2017

    Alternate Names:
    C509 NCI drug code

    Drug Info:

    Publications:
    Messingham et al., 2001, Testosterone receptor blockade restores cellular immunity in male mice after burn injury., J. Endocrinol.
    Pastor-Soler et al., 2002, Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens., Biol. Reprod.
    Zhang et al., 2005, Survivin mediates resistance to antiandrogen therapy in prostate cancer., Oncogene

  • DTC: FLUTAMIDE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL806 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: flutamide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • CIViC: FLUTAMIDE

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Robinson et al., 2015, Integrative clinical genomics of advanced prostate cancer., Cell

  • TTD: Flutamide

    • Version: 2020.06.01

    Alternate Names:
    D0Y0SW TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL806

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL806

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Flutamide

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21