DGIdb - FLUTAMIDE Drug Record

FLUTAMIDE chembl:CHEMBL806 ApprovedAntineoplastic

Alternate Names:

EULEXIN
FLUTAMIDE
DROGENIL
SCH-13521
NSC-215876
CHIMAX
NFBA
EULEXIN®
FLUTAMIDUM
NIFTOLIDE
ALPHA,ALPHA,ALPHA-TRIFLUORO-2-METHYL-4'-NITRO-M-PROPIONOTOLUIDIDE
4'-NITRO-3'-TRIFLUOROMETHYLISOBUTYRANILIDE
FLUTAMIDA
NIFTOLID
FTA
FLUTAMID
drugbank:00499
rxcui:4508
chembl:CHEMBL806
pubchem.compound:3397
chemidplus:13311-84-7

Drug Info:

Drug Class	antineoplastic agents, hormonal
Year of Approval	1989
FDA Approval	1989
Drug Class	small molecule
Drug Indications	Antineoplastic Agents, Hormonal

(6 More Sources)

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Zhang et al., 2005, Survivin mediates resistance to antiandrogen therapy in prostate cancer., Oncogene
Messingham et al., 2001, Testosterone receptor blockade restores cellular immunity in male mice after burn injury., J. Endocrinol.
Montalvo et al., 2000, Effect of flutamide-induced androgen-receptor blockade on adenylate cyclase activation through G-protein coupled receptors in rat prostate., Cell. Signal.
Martelli et al., 2000, Evaluation of flutamide genotoxicity in rats and in primary human hepatocytes., Pharmacol. Toxicol.
Balk, 2002, Androgen receptor as a target in androgen-independent prostate cancer., Urology
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Pazos et al., 2000, Mechanisms of reduced body growth in the pubertal feminized male rat: unbalanced estrogen and androgen action on the somatotropic axis., Pediatr. Res.
Chang et al., 1999, Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells., Proc. Natl. Acad. Sci. U.S.A.
Shilling et al., 2000, The non-aromatizable androgen, dihydrotestosterone, induces antiestrogenic responses in the rainbow trout., J. Steroid Biochem. Mol. Biol.
Robinson et al., 2015, Integrative clinical genomics of advanced prostate cancer., Cell
Yu et al., 2006, Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1., J. Leukoc. Biol.
Vinggaard et al., 2002, Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz., Toxicol. Sci.
Kritzer et al., 2001, Administration of tamoxifen but not flutamide to hormonally intact, adult male rats mimics the effects of short-term gonadectomy on the catecholamine innervation of the cerebral cortex., J. Comp. Neurol.
Harmsen et al., 2009, Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor., Cancer Chemother. Pharmacol.
Hsieh et al., 2005, PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage., Am. J. Physiol. Heart Circ. Physiol.
Pastor-Soler et al., 2002, Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens., Biol. Reprod.
Fowler et al., 1995, Prostate specific antigen after gonadal androgen withdrawal and deferred flutamide treatment., J. Urol.
Wang et al., 2005, Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism., Asian J. Androl.

FLUTAMIDE PEBP1

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12377983

Sources:
NCI
FLUTAMIDE AQP9

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12021052

Sources:
NCI
FLUTAMIDE VIP

Interaction Score: 0.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10822172

Sources:
NCI
FLUTAMIDE TH

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11223814

Sources:
NCI
FLUTAMIDE CDKN1A

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16281084

Sources:
NCI
FLUTAMIDE KLK3

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7541862

Sources:
NCI
FLUTAMIDE MPO

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16330533

Sources:
NCI
FLUTAMIDE IL2RA

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11312147

Sources:
NCI
FLUTAMIDE BIRC5

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15735703

Sources:
NCI
FLUTAMIDE G6PD

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
FLUTAMIDE NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18839173

Sources:
PharmGKB
FLUTAMIDE AR

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Androgen Receptor antagonist

PMIDs:
10822172 10752671 12231070 11752352 10879806 10500149 11162924 26000489

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND CIViC TTD
FLUTAMIDE RORC

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUTAMIDE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
FLUTAMIDE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528 22931300

Sources:
DTC PharmGKB
FLUTAMIDE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
FLUTAMIDE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16055512

Sources:
DTC NCI
FLUTAMIDE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUTAMIDE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: FLUTAMIDE
- Version: 01-August-2011
Alternate Names:

FLUTAMIDE Primary Drug Name

Drug Info:

Year of Approval 1989

Drug Class antineoplastic agents, hormonal

Publications:
TdgClinicalTrial: FLUTAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antineoplastic Agents, Hormonal

Drug Class small molecule

FDA Approval 1989

Publications:

NCI: FLUTAMIDE

Version: 14-September-2017

Alternate Names:

C509 NCI drug code

Drug Info:

Publications:

Messingham et al., 2001, Testosterone receptor blockade restores cellular immunity in male mice after burn injury., J. Endocrinol.

Pastor-Soler et al., 2002, Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens., Biol. Reprod.

Zhang et al., 2005, Survivin mediates resistance to antiandrogen therapy in prostate cancer., Oncogene

DTC: FLUTAMIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL806 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
PharmGKB: flutamide
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
CIViC: FLUTAMIDE
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Robinson et al., 2015, Integrative clinical genomics of advanced prostate cancer., Cell
TTD: Flutamide
- Version: 2020.06.01
Alternate Names:

D0Y0SW TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL806
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL806
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Flutamide
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Androgen Receptor antagonist

FLUTAMIDE Drug Record

FLUTAMIDE chembl:CHEMBL806 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12377983

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12021052

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10822172

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11223814

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16281084

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7541862

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16330533

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11312147

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15735703

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18839173

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Androgen Receptor antagonist

PMIDs: 10822172 10752671 12231070 11752352 10879806 10500149 11162924 26000489

Sources: DTC TdgClinicalTrial ChemblInteractions TEND CIViC TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528 22931300

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16055512

Sources: DTC NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
12377983

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12021052

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10822172

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11223814

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16281084

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7541862

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16330533

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11312147

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15735703

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
18839173

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Androgen Receptor antagonist

PMIDs:
10822172 10752671 12231070 11752352 10879806 10500149 11162924 26000489

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND CIViC TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528 22931300

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16055512

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

FLUTAMIDE Primary Drug Name

Drug Info:

Year of Approval 1989

Drug Class antineoplastic agents, hormonal

Drug Info:

Drug Indications Antineoplastic Agents, Hormonal

Drug Class small molecule

FDA Approval 1989

Alternate Names:

C509 NCI drug code

Alternate Names:

CHEMBL806 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Publications:

Robinson et al., 2015, Integrative clinical genomics of advanced prostate cancer., Cell

Alternate Names:

D0Y0SW TTD Drug ID