DGIdb - FLUVOXAMINE Drug Record

FLUVOXAMINE chembl:CHEMBL814 Approved

Alternate Names:

N06AB08
FLUVOXAMINE
U-23000
FLUVOXAMINUM
FLUVOXAMINA
LUVOX®
drugbank:00176
pubchem.compound:5324346
chembl:CHEMBL814
rxcui:42355
chemidplus:54739-18-3

Drug Info:

Drug Class	antidepressive agents, second-generation
Year of Approval	1994
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antidepressant

(3 More Sources)

Publications:

Benedetti F et al., 2010, Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine., Eur Psychiatry
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Williams et al., 2010, Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)., Cochrane Database Syst Rev
Miolo et al., 2002, Photoisomerization of fluvoxamine generates an isomer that has reduced activity on the 5-hydroxytryptamine transporter and does not affect cell proliferation., Eur. J. Pharmacol.
Millan et al., 2003, Blockade of serotonin 5-HT1B and 5-HT2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes., Psychopharmacology (Berl.)
Suhara et al., 2003, High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography., Arch. Gen. Psychiatry
Dell'Osso et al., 2005, Fluvoxamine: a selective serotonin re-uptake inhibitor for the treatment of obsessive-compulsive disorder., Expert Opin Pharmacother
Irons, 2005, Fluvoxamine in the treatment of anxiety disorders., Neuropsychiatr Dis Treat
Inoue, 2004, [Analysis and its application for prevention of side-effects of drugs and for evaluation of drug responsiveness]., Yakugaku Zasshi
McMahon et al., 2001, Role of 5-HT(2a) and 5-HT(2B/2C) receptors in the behavioral interactions between serotonin and catecholamine reuptake inhibitors., Neuropsychopharmacology
Kakiuchi et al., 2001, Effects of aging on serotonin transporter availability and its response to fluvoxamine in the living brain: PET study with [(11)C](+)McN5652 and [(11)C](-)McN5652 in conscious monkeys., Synapse
Yoshida et al., 2002, Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients., Prog. Neuropsychopharmacol. Biol. Psychiatry
Carrillo JA et al., 1996, Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity., Clin Pharmacol Ther
Ozdemir V et al., 2001, Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C-->A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine., J Clin Psychopharmacol
Kurose K et al., 2012, Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression., Psychiatry Res
Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
Ishiguro S et al., 2011, Determinants of pharmacodynamic trajectory of the therapeutic response to paroxetine in Japanese patients with panic disorder., Eur J Clin Pharmacol
Yevtushenko OO et al., 2010, Early response to selective serotonin reuptake inhibitors in panic disorder is associated with a functional 5-HT1A receptor gene polymorphism., J Affect Disord
Illi A et al., 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression., Neuroreport
Kato M et al., 2009, Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder., Am J Med Genet B Neuropsychiatr Genet
Baune BT et al., 2008, Serotonin receptor 1A-1019C/G variant: impact on antidepressant pharmacoresponse in melancholic depression?, Neurosci Lett
Drago A et al., 2008, 5-HT1A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies., Int J Neuropsychopharmacol
Kato M et al., 2009, 5-HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients., Psychiatry Res
Kato M et al., 2006, Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients., Neuropsychobiology
Suzuki Y et al., 2006, Polymorphisms in the 5-hydroxytryptamine 2A receptor and CytochromeP4502D6 genes synergistically predict fluvoxamine-induced side effects in japanese depressed patients., Neuropsychopharmacology
Breitenstein B et al., 2016, Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study., J Psychiatr Res
de Klerk OL et al., 2013, ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder., Pharmacogenomics J
Uhr M et al., 2008, Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression., Neuron

FLUVOXAMINE MDGA2

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22445761

Sources:
PharmGKB
FLUVOXAMINE SLC6A4

Interaction Score: 1.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fluvoxamine , fluvoxamine-CR,Luvox

Novel drug target Established target

PMIDs:
20687077 12208313 12721776 12695316 16316311 18568110 15170064 11166521 11304754 11817517

Sources:
TdgClinicalTrial TEND
FLUVOXAMINE HTR1A

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 21688171 19800133 19590397 18484082 18387740 18047755

Sources:
PharmGKB
FLUVOXAMINE COMT

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20619611

Sources:
PharmGKB
FLUVOXAMINE FGF2

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FLUVOXAMINE HTR2A

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19361869 16874005 16205777

Sources:
PharmGKB
FLUVOXAMINE ABCB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26704739 22641028 18215618

Sources:
PharmGKB
FLUVOXAMINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8823236 11763009

Sources:
PharmGKB
FLUVOXAMINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
FLUVOXAMINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
FLUVOXAMINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
FLUVOXAMINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA

TEND: FLUVOXAMINE
- Version: 01-August-2011
Alternate Names:

FLUVOXAMINE Primary Drug Name

Drug Info:

Year of Approval 1994

Drug Class antidepressive agents, second-generation

Publications:
TdgClinicalTrial: FLUVOXAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: FLUVOXAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL814 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: fluvoxamine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Benedetti F et al., 2010, Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine., Eur Psychiatry

Ozdemir V et al., 2001, Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C-->A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine., J Clin Psychopharmacol

Carrillo JA et al., 1996, Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity., Clin Pharmacol Ther

TTD: Fluvoxamine
- Version: 2020.06.01
Alternate Names:

D03HFG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL814
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Fluvoxamine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	fluvoxamine , fluvoxamine-CR,Luvox
Novel drug target	Established target

FLUVOXAMINE Drug Record

FLUVOXAMINE chembl:CHEMBL814 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22445761

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name fluvoxamine , fluvoxamine-CR,Luvox Novel drug target Established target

PMIDs: 20687077 12208313 12721776 12695316 16316311 18568110 15170064 11166521 11304754 11817517

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 21688171 19800133 19590397 18484082 18387740 18047755

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20619611

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19361869 16874005 16205777

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26704739 22641028 18215618

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8823236 11763009

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

TEND: FLUVOXAMINE

Alternate Names: FLUVOXAMINE Primary Drug Name

Drug Info: Year of Approval 1994 Drug Class antidepressive agents, second-generation

Publications:

TdgClinicalTrial: FLUVOXAMINE

Alternate Names:

Drug Info: Drug Indications antidepressant Drug Class Small Molecule FDA Approval approved

Publications:

DTC: FLUVOXAMINE

Alternate Names: CHEMBL814 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: fluvoxamine

Alternate Names:

Drug Info:

TTD: Fluvoxamine

Alternate Names: D03HFG TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL814

Alternate Names:

Drug Info:

Publications:

FDA: Fluvoxamine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
22445761

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fluvoxamine , fluvoxamine-CR,Luvox

Novel drug target Established target

PMIDs:
20687077 12208313 12721776 12695316 16316311 18568110 15170064 11166521 11304754 11817517

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
23733030 21688171 19800133 19590397 18484082 18387740 18047755

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20619611

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19361869 16874005 16205777

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26704739 22641028 18215618

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8823236 11763009

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Alternate Names:

FLUVOXAMINE Primary Drug Name

Drug Info:

Year of Approval 1994

Drug Class antidepressive agents, second-generation

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL814 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D03HFG TTD Drug ID